After some of Portland's homeless youth go missing, Nick discovers a black market supplying the Grimm world with human organs. As the investigation continues, Nick and Juliette befriend a pair of homeless siblings, Hanson and Gracie, whose friends have gone missing.
Jerome has Patricia’s amulet. Nina & Fabian have to get the gem and do a trade for the amulet. Nina sees a riddle. Jerome has the gem, but has a problem. Mara finds the missing chapter of the Book of Isis. The Sibunas find a clue to the Spider task.
On 11 July 1991, Nigeria Airways Flight 2120 is taking off from Jeddah's King Abdulaziz International Airport with 247 Nigerian Hajj pilgrims and 14 crew members on board. A tire bursts during the takeoff, starting a fire on the landing gear. The crew is unaware of the fire and retracts the gear after takeoff; and the fire spreads. Encountering problems, the crew then tries to return the aircraft to the airport, but it breaks up during flight and crashes about three kilometres from the runway.
On the way home with his family, Danny hits a man with his car who is fleeing from a gunman, and his family gets caught in the crossfire when Danny fires his weapon at the gunman. Frank deals with 9/11 guilt from impending loss of a friend with whom he worked at Ground Zero.
Reagan wants to secure a spot at a prestigious preschool for Amy and tries to win favor by organizing a charity auction with Ava's help. Elsewhere, Chris and his brother find that they haven't outgrown their competitive ways from childhood.
The Machine gives Reese and Finch the number of a down-and-out man who has been pushed too far, and they're forced to turn to former Person of Interest, Zoe Morgan, for help.
As Meredith puts Zola to bed and falls asleep, she begins to wonder -- what if her mother had never had Alzheimer's and she'd had loving, supportive parents? The reverberations of a happy Meredith Grey change the world of Seattle Grace as we know it. What if she had never met Derek in that bar and he had never separated from Addison? What if Callie and Owen had become a couple long before she met Arizona? And what if Bailey never evolved from the meek intern she once was?
Cassie enlists the Circle's help when she receives a frightening warning about the witch hunters' return. At the same time, her true feelings for Adam and Jake surface during a birthday party that Ethan decides to throw with the help of Diana. Meanwhile, Faye and Melissa take their inner power to a chilling new level when they try a little of Lee's "Devil's Spirit."
Sheriff Forbes delivers some disturbing news to Alaric and Elena about the weapon used in a recent murder. In the Salvatore brothers’ escalating quest to kill Klaus, Stefan turns to Bonnie and Abby, while Damon reaches out to an old acquaintance for help in setting up an elaborate plan. Intent on a plan of his own, Klaus hosts a strange dinner party, where he reveals another story from his family’s violent past until an unexpected guest brings the party to an end. Meanwhile, Caroline is heartbroken when she is unable to stop a tragedy from unfolding.
Jane and the CBI narrow down the list of suspects after a disgraced clothing designer on the verge of a comeback becomes a fashion victim. Meanwhile, FBI Agent Darcy continues her investigation into finding Red John.
Liz finds a secret weapon to help in her contract negotiations with Jack, Kenneth leaves his job because he feels under-appreciated, and Tracy and Jenna perform at their accountant's ungrateful son's Bar Mitzvah.
Sheldon's selfish demands force Leonard to reconsider their friendship. Meanwhile, Wolowitz tries to pick his astronaut nickname.
Mara investigates a ‘profile’ on the website.The goose passes the gem, but Mara drops it. Patricia wears the fake amulet. As the Sibunas explore the spider’s web task, Patricia arrives to warn them. Mr Sweet tells Mara about Vera's job.
Jim returns from jury duty, only to have to deal with Dwight's pesky questions about the details of the case. Elsewhere, Angela and her senator beau welcome their baby.
Leslie works to find Ann a Valentine's date. Ron helps Ben with a scavenger hunt, and Chris becomes depressed over his love life.
Military historian Saul David explores how wars are really fought - in the backroom of military planning. He begins by looking at how to keep an army fed and housed.
Sheldon counsels Sam's friend, Rick, an Army veteran suffering from PTSD who harbors a secret sexual trauma; Erica and Mason are involved in a car accident that forces Cooper and Charlotte to further come to grips with their future; Violet and Pete struggle to navigate life after marriage when he finds her kissing Scott; and Addison and Jake attend a medical conference they won't soon forget.
The All Stars take to the streets of New York to convince total strangers to part with their clothes in the name of fashion. Their muse's outfits are ripped apart and reborn in the hands of an All Star.
Isabel's new boyfriend Frank, an all-star baseball athlete, gets robbed, and Walter steps in to help find his stolen collectibles. But in the process, Walter learns Frank has lost something more meaningful than memorabilia. Then, to earn Willa's trust, Leo and Walter bring her in on the case.
Jason, egged on by his friends (and several beers), posts an ad looking for Jane on missed connections. Tina loses her license to mock him, when, while anxiously awaiting a text from Brett, she de-virginizes an intern. Stacey and Eric have new mattress sex on a mattress that turns out to be anything but new.