When everyone ends up at Baze’s loft for Thanksgiving, it isn’t long before a few big secrets are exposed. Baze worries that his father, Jack, will discover he is dating his boss, Emma; Lux worries that her parents will find out she is spending time with Eric; Tasha worries that something very dark from her not-too-distant past will be discovered; and Cate worries that if she tells Ryan the truth it will further complicate their already complicated relationship.
The crew's new-found control over Destiny's flight path introduces new risks when they find themselves in the middle of a war between two races.
Gabe decides to run for class president when the other candidate becomes ill. Students begin losing their powers shortly after the campaigning begins. Ian discovers a chemical called "Chemica Desin" implanted in the campaign buttons and infecting the students. Ross Anderson, the campaign manager for Emily Wright (Gabe's election opponent) was the culprit. Gabe wins the election and Headmaster and Nurse ask Ross to show them how she improved the chemical using only Tower Prep supplies.
Jesse shrugs off Paul's optimism that his parents won't abandon him when he needs them most.
Adele sees Paul's chronic indecisiveness as a source of his discontent.
New Directions heads to the big Sectionals competition to go head-to-head against the Warblers and the Hipsters. While trouble brews between some of the young couples, Emma and Carl grow closer.
Mike goes to Ketucky to learn about race horse nutrition. That involves collecting the horse's vital statistic from it's blood, poop and pee. Fortunately there are plenty of flies to distract Mike while he prepares the samples.
Brooke and Julian go skydiving, while Haley sets up a concert at Tric featuring Kid Cudi. Meanwhile, Quinn sneaks out of town to visit a familiar face.
Both the ATF and the Russians prove obstacles as the club looks to heal old wounds.
Daniel, Amanda, and Zoe race to stop Clarice's master plan and save thousands of lives before Caprica is changed forever.
Jim and Stephanie plan a romantic evening to celebrate their 18th anniversary, but they find themselves using their powers to deal with a serial arsonist with special powers of his own; Daphne and J.J. join forces to win money in a poker game.
Chuck, Serena, Blair, Dan, Jenny and Eric find themselves faced with a crisis when a member of one of their families is hospitalized. Meanwhile, Nate attempts to help his parents, The Captain and Anne, put their complicated past behind them and reconcile.
Don meets a homeless girl begging for money in the street and asks her out on a date.
It's the day after Thanksgiving and Chuck faces the most awkward of family reunions when mom comes over for dinner—along with the dangerous Alexei Volkoff. Back at the Buy More, Morgan deals with the busiest shopping day of the year as Jeff and Lester hatch their latest scheme.
Lightman is hired by a terminally ill restaurant owner to find his daughter's killer as his dying wish.
Frances leans on Paul for support as her sister's health deteriorates.
Naomi jumps back into the dating world when she notices one of Ivy’s hot surfer friends, Zach, and tries to impress him by pretending to know how to work a surfboard. Ivy remains upset by her mother’s actions with Oscar and decides to rebuild her relationship with her father. Dixon and Annie decide to help Debbie get back into the dating world by signing her up for online dating, but while on her first date, she and Ryan sneak away for some one-on-one time at the Beach Club. While at the beach luau, Teddy gets jealous when he sees Ian with another guy and allows his feelings to control his actions. Navid and Adrianna’s relationship is strained now that she has found fame, which leads him closer and closer to Silver.