Mike and KITT must find a stolen serum which will result in the recipients maximum physicality when used, before it lands into the wrong hands. Meanwhile, Sarah's new duties have her overwhelmed as she quickly learns what it will take to re-institute the Foundation for Law and Government.
The romance between Inspector Murdoch and Dr. Ogden heats up as Murdoch finds himself investigating the death of a young woman working as a high-class prostitute.
Paddy wakes up to find himself chained to a bed in a strange room, unable to remember how he got there, and tension arises between Frank and Monica following a DSS investigation. Carl schemes to discover Micky's sexuality, Tom's last-ditch romantic gesture to regain Debbie's affection backfires, and Carrie decides it is time for a change
From the day that a picture of a row of cherry trees in a desolate winter was obtained, every time Natsume wakes up, his rooms is covered in petals. Trying to solve the root of this activity, Natsume and Nyako Sensei try and return the picture to Miya, a shadowy figure who accompanies the picture. But why can't they return it to Miya...?
Harry loses his cool with 3 swimmers that he's forced to rescue just seconds after warning them not to swim in a dangerous area. However, calling them "imbeciles" and "idiots" puts him in hot water.
Sam, Ben and Sock encounter a few surprises on their return from a road trip; Andi refuses to speak to Sam; the Devil has a new assignment.
As Christian and Liz make their wedding plans, he also looks for a new cancer treatment. Meanwhile, Ram Peters drops Kimber for a newer model, while Teddy informs Sean that someone close to her is gone, and Sean and Christian repair a couples neck wounds which look strikingly similar at McNamara/Troy.
LuAnn's housekeeper returns after a monthlong trip to the Philippines---to the relief of LuAnn, who had been saddled with the extra house chores. In other developments, Jill organizes a charity event; Simon and Alex enjoy a spa day; Kelly participates in an elite Hamptons horse show; and Ramona's husband organizes a tennis doubles rematch with Jill---resulting in a volley of egos.
When a teenager is murdered, the alleged killer's defence barrister has an audacious plan up her sleeve.
Charlie has to remove a half-naked woman from his bedroom before Chelsea arrives.
Juma and his men take the White House by storm, killing most of the Secret Service and trapping Taylor and Jack in the saferoom. His efforts to extract her are thwarted until he is informed that the President's daughter is in the White House as well. Renee and Larry try to convince Vice President Hayworth to let them rescue the President, but Hayworth will not budge until the FBI can produce proof that she is not in imminent danger.
Not even at the halfway point of this hellacious day, two planes have collided outside of D.C., there has been an attempt on a chemical plant in Ohio, the President’s husband’s life has been threatened and the nation remains at risk. When Dubaku’s evil plan escalates to his boss, General Juma (guest star Tony Todd), the stakes are raised and steadfast President Taylor faces a deepening foreign policy dilemma.
Chuck gets jealous when Sarah has to seduce a Fulcrum agent. Meanwhile, Jeff and Lester start looking for the "Buy More Babe" as a way of finding a new employee.
The gang thinks that Barney must have a secret girlfriend after noticing his bizarre behavior.
A paintball game leads to a fight between Sheldon and Penny, and romance for Leslie and Wolowitz.
The contestants make over a group of female extreme fighters into their drag daughters. Xena herself, Lucy Lawless, makes a guest appearance to judge the girls' combat prowess.
The squad tracks down a serial killer who has been mutilating women; Ham is temporarily partnered with Butch during Bobby's absence; Earl tries to persuade Grace to help Leon.
After receiving a tip from "Rebel", Matt and Peter race to Building 26 to rescue Daphne and recover files that will expose the government's plans for those with abilities. Claire finds help from an unlikely source in smuggling Alex out of the city. As Sylar and Luke continue their road trip, Sylar begins to have memories of his father that lead him to the truth about his mother. Meanwhile, "The Hunter" puts his own agenda into action with an explosive surprise for one of our heroes.