As Tommy begins his reelection campaign, he turns to his sister, Mary-Kate, rather than Eileen for support; Colin Carr (Brian F. O'Byrne), Tommy and Michael's estranged Irish cousin whom Rose deeply distrusts, returns to Providence.
Dave and Katie balk at Dr. Foster's idea to spend time together without their children; Carolyn tries a different approach to get pregnant; Jamie finds herself drawn to Nick despite her promise of celibacy.
The 2006 murder of an Amish teen who left home to visit Philadelphia as part of rumspringa, an Amish rite of passage, is reinvestigated when the victim's sister arrives to look for her.
Kevin, Nora and Kitty go to pick up Justin who has just returned home from the war. McCallister finds that he's getting closer to Walkers. Meanwhile, the truth is revealed between Sarah and Rebecca and Tommy is not able to get the hang of being a father.
Joe gets a leg transplant to allow him to walk again, only for his new legs to make him abandon Bonnie and the guys.
Bobby is selected to be a powder-puff cheerleader, but Peggy and the rest the PTA threaten to disband the group after the PTA president decides that it's sexist.
Sharon has sworn off men and has been celibate for three months. Brett has had a one night stand and Kim throws him out. Sharon becomes too lusty watching sportsmen on TV and uses chocolate as a substitute.
Lynette kicks Tom out of her chemotherapy sessions. Susan is mistaken for a stripper. Bree attempts to steal a prize-winning recipe from Katherine.
Homer starts working in the towing business, but gets into some trouble when the town sets up Homer to look like he is towing on a rival's turf after he becomes greedy with power. Meanwhile, Marge signs up for a counseling program that teaches parents how to raise young children to become independent, but the program works a little too well on Maggie.
Dexter is finding it hard to have closure on killing his brother. There is a new FBI agent to head the "Bay Harbor Butcher" case. Debra is finding it tough to put the past behind her.
The wounded, the scarred, and the disfigured unite. Meanwhile, an oblivious Dethklok spends their studio time recording onto the purest of all analog formats: water.
Larry is unrattled by a book about freaks and a bad chauffeur.
Frustrated by his repeated defeats at their hands, Ronan the Accuser asks the powerful Grandmaster to stage a contest that would give him the chance to beat the Fantastic Four.
Carly, Sam and Freddie want their show to be reviewed. Carly risks receiving a bad review when she insults the annoying eleven year old who runs a popular site that rates web casts.
Ben's son, Ken, turns ten. As a birthday gift, Ben gives Ken an Omnitrix, with ten aliens. Ken soon befriends Devlin, a youth with some ties to an archenemy of Ben's.
When it appears that Timber Wolf viciously attacked his own father, the Legion try to catch him. while Chameleon Boy and Phantom Girl work to clear his name.
When Count Vertigo starts trouble in Gotham City, Justice Leaguer Green Arrow teams up with Batman to defeat his arch-foe.
DNA is Thicker than Water: Darius comes down hard on the Darks and places the blame squarely on Dark Leo's spiky shoulders. To prove that he is an apt leader Dark Leo devises a plan to destroy the Turtles from within.