After recuperating from her health scare, Adrianna returns and tries to make amends with Naomi, but her ex-BFF refuses to forgive her for the betrayal. Adrianna makes a surprising connection with Navid, who helps her through her situation. Meanwhile, Annie and Ethan finally take their rapidly growing romance to a new level during the school's homecoming dance, causing Naomi to feel jealous.
Gibbs and his team are searching for a cyber serial killer who takes videos of his victims. The team quickly finds out that the video's of the dead victims are false.
The Suttons say goodbye to Johnny, and Charles pops the question.
Mike teams up with the boys from Bartos Bait & Fish to catch leeches that will later be sold for fish bait. Then it's off to the Green Tripe factory in Hollister, CA where Mike helps make BARF (Biologically Appropriate Raw Food) for dogs.
Alien pods are discovered in an abandoned garage; a retirement-home resident has a deadly gift; a patient wishes to be reattached to his formerly conjoined twin; a power-company employee confronts a scientist who is stealing power to create the ultimate weapon.
Casey is in panic mode after the diary that details her unsettling romantic dreams about Truman goes missing. Believing that Derek and Edwin took it, Lizzie and Marti attempt to get the diary back by making their stepbrothers' lives miserable.
Vic closes in on Shane, Mara and their sick young son; Claudette dismantles the Strike Team; Pezuela offers Acevada "assistance" for his mayoral campaign; Rita Denton (Frances Fisher) comes on to Dutch; and Billings' ex-wife and daughter are fearful when a registered sex offender moves into their neighborhood.
An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagnosis before both die. Meanwhile, Cuddy adopts a newborn but when the birth mother displays a rash, she has to make a decision between putting the mother or daughter at risk.
When a girl is found covered in blood and holding the murder weapon that killed her best friend, she becomes an obvious suspect, though she can't remember anything. But Jane, believing she's innocent, engineers a risky maneuver in which she must relive the terrifying events in order to spark her memory.
The team must shift their attention from a case they are working on and hand it over to Martin, after a child is reported to have been kidnapped at a mall.
Efficiency expert Emmett Milbarge pays the Buy More a visit to inspect the branch, while a global terrorist looks for Jeff. Chuck needs to socialize with Jeff to find out about his connection to the terrorist. Finally, it all comes down to video games and the prevention of World War III.
Jenny has a new young model friend, named Agnes, who encourages Jenny to explore her wild side, and also to confront Eleanor Waldorf who is planning to steal Jenny's designs in order to pass them off as her own. Meanwhile, Serena and Dan attend Rufus' latest art opening as friends, but then Serena meets an artist, named Aaron Rose, and the evening gets a little uncomfortable for Dan. Elsewhere, Blair attempts to seduce Chuck, but he proves to be tougher than she ever imagined. Also, Jenny begins to have a mutual feelings with Nate as he's staying with her, Dan, and Rufus while searching for a place to live.
Shirley defends the notorious Catherine Piper after she accidentally blows up her doctor. Meanwhile, Alan and Denny take a break from the office, but they are out of their element at a dude ranch in Utah.
Harry's Roadhouse (Santa Fe, N.M.) • Dor-Stop Restaurant (Pittsburgh, Pa.) • Surrey's Cafe (New Orleans, La.) Guy Fieri checks out breakfast from east to southwest: In New Orleans, a juice bar makin' bagels from scratch; a New Mexico roadhouse mixin' Philly food with Southwestern favorites; and in Pittsburgh, a family joint scratch-making pancakes with everything from peanut butter to pumpkin.
Lucas' novel receives interest from a suprising person, as does Mouth as he meets his new intern. Jamie begins to develop a crush on Sam and her rebellious ways, while someone becomes enamored with Brooke. Meanwhile, Haley and Nathan discuss his return to baskeball as his comeback begins to look more like a reality.
Desperate to regain her memory, Sam opts to join a clinical trial and starts taking pills for her memory. Sam's memories start coming back, but she doesn't like what she learns about her former self. Elsewhere, someone confuses Dena and Andrea as being a gay couple, which frustrates Andrea and sends her on the hunt to find someone hotter than Dena.
Trapped, Nathan and Tracy must fight to save their lives against Suresh, who has changed dramatically. Elle returns with shocking news for Claire and her family. Meanwhile, Angela tries to convince Sylar to save Peter; Daphne is ordered to kill Matt or she will be killed herself; and Hiro questions Usutu's advice.
MUFON - the Mutual UFO Network - investigate a UFO sighting, and possible alien abduction, using the tools of science, psychology and law enforcement.
Harry vows revenge by taking down the head of Russia's intelligence service in Britain with the help of Lucas North. Lucas's loyalties, however, are secretly no longer with MI5 and he exploits Harry's trust to help a Russian submarine destroy Britain's communications system, causing financial and social chaos.