Timmy wishes Cosmo was a talking car so that he and his fairies can search for the missing Mama Cosma.
After Georgina reveals the true reason Serena left Manhattan, Serena goes back into her old habits. Her friends Blair, Nate, and Chuck, in order to help her, have to put their differences aside. Meanwhile, Rufus is excited when his band is invited to perform at a Rolling Stone-sponsored concert, but Lily is the last person on earth he expects to see at the performance, especially since her wedding rehearsal dinner is the same night.
Lucas is crushed by devastating news. Quentin is pushed to his limits during a Ravens game. Dan's is second on the donor recipient list to get a new heart. Haley thinks about her decision to release a new album while Brooke's baby undergoes emergency surgery and a shocking truth stuns Peyton, told by Lucas.
When Barney and Abby realize that they have one thing in common - their mutual hatred of Ted - the "couple" decides to go to the bar to flaunt their new relationship in Ted's face.
The crew find a boy who has found a cache of guns. The boy is later kidnapped which ends up ruining a date for Kate and Jim. Meanwhile, one crew member faces losing the love of his life.
A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who it was, and what they had.
Penny wants to throw a surprise party for Leonard, but Sheldon's indulgence at an electronics store throws her off-track.
Tom's Bar-B-Q (Memphis, Tenn.) • Marlowe's Ribs (Memphis, Tenn.) • Leonard's BBQ (Memphis, Tenn.) • Cozy Corner (Memphis, Tenn.) Guy Fieri rolls through Memphis, one of America's greatest barbecue towns. He checks out an 86-year old legend with the killer pulled pork sandwich and a true local favorite, barbecue spaghetti plus a tiny joint where the specialty is barbecued Cornish hen and serious ribs at a joint with its own fleet of pink Cadillacs.
In the fourth season finale, Allison tries to help a young couple who thinks their house is haunted, but her efforts result in murder. Meanwhile, Meghan Doyle tries to sell her controlling interest in Joe's invention and Joe tries to save his own stake in it. Also, the election between Devalos and Tom Van Dyke takes place.
Lauren tries to uphold her friendship to Audrina, but is it already too late? Meanwhile Spencer tries to win Heidi back and risks her career to do so.
Charlie's attracted to an older self-help author. Alan and Jake clash over a project for school.
When a man is killed due to a fake 911 call, Horatio must face off with a private investigator who is systematically destroying the team. The PI also digs into the team's personal lives and gets both Calleigh and Eric pulled off the case.
A wannabe singer Tommy Sour was found on a grassy location. The investigation leads Brennan, Booth, and Cam to the Checker Box Restaurant where Tommy used to sing. There are several suspects who took part in the open mike contest there, with talent scouts in the audience. The group comes together with a startling revelation for Brennan.
Kris and Junior face resentment after announcing their plans to marry each other.
After almost dying in a car crash, Stan decides that he must do something important with his life, so he digs for the gold he claims Iran-Contra figure Oliver North buried beneath his house. Meanwhile, Roger poses as a sexually provocative female office worker, hoping he'll be harassed so he can sue over it.
When Chris attempts to buy Rochelle perfume as a Mother's Day gift, he discovers he cannot afford it and buys it from Risky. However, Rochelle breaks out in hives and takes Chris to the store she believes he bought it from. Meanwhile, Drew and Julius do a spot of spring cleaning and make an expensive find.
Wanting to spend some quality time with his son, Hank distracts Dale, Bill and Boomhauer with a boat building competition. However, when bats attack the construction garage, Hank has to give up his idea of spending time with Bobby.
The English Reformation is in full swing. Queen Anne suffers from nightmares and feels threatened by Katherine and her daughter. Henry pays an unplanned visit to an old friend, Sir John Seymour, father of Jane Seymour.