When a musician is murdered, Don and his team must race to find the culprits. They need Charlie's help, but he is busy with Amita's parents coming for a visit.
A temperamental sitcom actress is found dead in her Las Vegas hotel room, and there are plenty of suspects. Soon afterward, her photo double is also killed, this time in Hollywood in the dead actress' car.
Neela's aortic rupture patient is in need of yet another follow up surgery, and they are starting to take a toll on her. Morris talks with a shrink about his experience with the jewelery thieves. Abby needs to make a tough decision when a new opportunity is presented to her.
In the second season finale, Jack moves on to a new job involving politics in Washington, but the position is not quite what he anticipated. Meanwhile, Liz suffers a pregnancy scare, Kenneth confronts rival page Donny when applying for a summer job, and Tracy works on his latest invention.
At night, Ash takes a walk near the Lake Valor with Pikachu when suddenly, something in the center of the lake begins to glow, and it turns out that Azelf appears. When Ash tries to approach it, the shadow disappears again. The next day, the second round of the Wallace Cup begins. May's Venusaur is then revealed, and there is a cameo appearance of May's Skitty battling in the second round. Dawn, May and Zoey make it to the semi finals but Ash loses to a tough coordinator called Kyle. After it is Dawn's turn to battle Kyle in the semi-final, she uses Piplup against his Crawdaunt. There are cameos of Norman, Caroline, Max, Kenny and Paul.
Ash and his friends have arrived at the Lake Resort where the Wallace Cup will take place. Zoey also arrives, and competes, too. Right when the contest began, Dawn becomes nervous and has trouble keeping her composure. Meanwhile, May decides to enter with Wartortle, and Ash enters with Buizel. There are cameos of Drew, Harley, Max, Norman, Caroline, and Solidad.
Simon passes his driving test at the first attempt, less on account of his skills than the fact that Tracey, the saucy examiner, finds him cute. As promised, he agrees to take his three friends to Thorpe Park, where he can get in free as he knows the man who clears up the sick. Once on the road, Will, Jay and Neil realize that Simon is a rubbish driver. (Until The Happy Foundation Shows Up)
Billie starts her own list, and she and Earl help out a grocery store bagger whom they share on their lists. However, Earl soon discovers that Billie doesn't completely understand the concept of karma and The List.
Inspired by Earl, Billie starts a list of her own and when Earl is getting annoyed by Billie's little habits, he decides to focus on working on the list instead. He picks a task that is on both of their lists, atones for the injury of a champion grocery-bagger and discovers a unique talent of his own. But Earl soon finds out that they have different ways of interpreting Karma.
Locke finds out where Jacob's cabin is. Life on the freighter becomes dangerous.
Jim is wearing his best golfing uniform because he is hitting the links with a potential client, Phil Maguire. This is a very important account for Jim because he needs to look good to Ryan, who recently put him on probation for his job performance. Andy and Kevin are also joining in the game to show their support.
Sam and Dean discover a doctor who, back in 1816, became obsessed with finding the secret of eternal life by taking people's vital organs. Meanwhile, Bobby finds Bela and Dean leaves Sam to confront her.
After Lex is attacked by a mysterious stranger, he and Clark both discover the last surviving member of the Veritas group who holds the secret to controlling the Traveler.
Michael is busy manning a job fair at Pam's alma mater, trying to find a summer intern. In an attempt to woo a major client, Jim, Andy, and Kevin go golfing.
After a hard day of work, Dr. Cox has the burden to tell his son Jack a good night story, so he disguises his hard day as a fairy tale about the little village Sacred Heartlia with Carla and Turk as the two-headed witch Turla, Elliot as the princess and J.D. as the village idiot. Other people featuring are the Janitor as the giant, Keith as the prince, Dr. Kelso as the dark lord Oslek, Ted as his hunchback and of course Dr. Cox as the brave knight.
Betty decides to patch things up with Charlie by throwing her an unforgettable baby shower. Meanwhile, Hilda decides to confront Justin's teacher after learning that he is failing gym class and Christina learns who the father of Wilhelmina's baby really is.
A truck driver goes missing after saving a boy's life, and the team determines if that has anything to do with his disappearance. Meanwhile, Jack's mental health is examined by a psychiatrist.
The gang posts videos on the Internet after a field trip is rained out.