Doug and Deacon discover they have more in common with each other's wives than their own, so they start hanging out with each other's wives as well. When Kelly tires of Doug, he ruins Deacon and Carrie's good time. Meanwhile, Arthur dispenses romance advise, and the recipient finds success simply doing the opposite.
Isis steals a magical pipe that can control animals and uses it to rob stores in Metropolis. When Ace and Krypto end up under her spell, Jimmy the rat has to fight her off.
Trump's children, Ivanka and Donald Jr. fill in for Carolyn and George for this task, which requires the remaining candidates to promote one of New York City's biggest tourist attractions.
As Rose gets ready to make a huge announcement, Simon breaks down as he realizes that he may have trapped himself in a marriage that he does not want. Meanwhile, Eric and Annie reminisce about their children and their younger days as they prepare for the rehearsal dinner and meet Rose's unconventional parents.
Mona is taking her break-up with Chase out on everyone, only to realize that she's also putting her professional career in jeopardy. Dee Dee's newly signed client is married but when she suspects he's having an affair she is faced with a moral dilemma. Meanwhile, Phyllis and Big Dee Dee assume the girls are planning a big Mother's Day celebration, since neither has suggested plans to celebrate.
Vicki and Aaron Newton are separated, with joint custody of their two sons, Aaron (12) and Kobe (5). Though the boys are angels for Dad, young Kobe saves his worst behavior for Mom. He is violent and destructive -- hitting, kicking, slapping, punching and swearing. He even throws rocks at Jo's head. Aaron isn't physically aggressive, but he does talk back to his mother. For the first time, Jo Frost observes life in two homes to hone her recommendations for each parent. But can she get them to collaborate on their child-rearing techniques?
When a serial dog killer starts stalking local parks, the team are reluctantly forced into taking on the case.
While attempting to return some personal effects Dr. Macy makes a startling discovery. Jordan and Lu butt heads over the morgue janitor and Lily prepares for the wedding.
Instead of getting a job, Bobby and Joseph discover that they can make more money, and look cooler, by hanging out on street corners and begging.
Brian's gay cousin Jasper visits the Griffin house and announces that he is engaged to his partner and wants to be married at their house. When Mayor West bans gay marriage in an effort to cover up and bring attention away from a scandal of his own, Brian resorts to hostile actions to try to change the Mayor's mind. Lois and Peter question their view towards gay marriage while Chris joins the "Young Republicans" Club to impress a girl.
Gabrielle and Carlos are shocked when the father of their baby shows up to take the baby back. Cops and a lawyer arrive to a house on Wisteria Lane. Lynette tries to help Ed heat up his sex life. Meanwhile, Karl decides to break up with Edie, as Edie has no idea that Susan is the "other woman." Edie causes a fight to break out in a bar, after she trips a waitress. Lastly, Bree is taken a step forward to help Peter when she finds out how bad his other addiction is.
The family attends "Stab-A-Lot: The Itchy and Scratchy Musical." The musical's director is a graduate of Springfield Elementary and Principal Skinner puts his foot in mouth when he makes sexist comments about her education and that of women in general. He tries to make the situation better, but only buries himself deeper and deeper until he is fired and replaced by Women's Educational Expert Melanie Upfoot. The first thing she does is split the school into girls and the boys. Lisa dislikes the way girls are being taught math and she ventures over to the boy's side of the school in search of a challenge. Disguising herself as Jake Boyman she starts attending the boy's school but while she finds the math problems more interesting, it is being a boy that is a greater challenge.
David and Carlos are still investigating the poison that is affecting Charringa's lemon crops in Florida, before the United States decide to bomb Cuba. Jill, on the other hand, asks Mayko to contact all the other labs using the same stem cells from Korea to let them know a retrovirus is in that strain. Bob offers to verify all the steps one more time with her and see if her findings are correct. Simon Jessup finding that Glenn responds to all the stimuli suggests that he undergoes brain surgery.
Huff gets an unexpected visit from his father. Teddy ends up meeting a very attractive young lady while down at the beach. Izzy finds herself arrested on a DUI charge. Beth decides that she will host a meeting of Paula's prayer group. Russell tracks down his young client, who is at a drug house, and then ends up joining in the festivities.
Vito considers starting a new life in New Hampshire, while Anthony continues his pursuit of revenge against Junior.
Addison's patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient's husband won't use contraceptives. Derek treats a divorce attorney who asks if Derek is in need of her services. While Izzie and George are talking about their personal lives they "overhear" part of Derek's conversation with the divorce attorney who calls herself one of Seattle's best. Alex gets in trouble with Addison yet again for not being able to keep his mouth shut when other people think he should. A legendary jazz musician refuses to see medical reason. The musician is Burke's musical hero. Finn makes Meredith breakfast.
While Santos is busy trying to select a new vice president, his wife finds her new responsibilities staggering. Meanwhile, Vinick ponders his next move.
Sunnyvale is finally going to get some publicity for their new "Convenients Store" and Bubbles "KIttyland" as a TV reporter comes to Sunnyvale. Lahey goes to the dump and finds something surprising. Randy has a new fan.