An axe murderer on death row is given a stay of execution just moments before it was to take place, on the grounds that there may have been tainted DNA analysis used at his trial. Now, without using any DNA evidence, the team must race against time and reexamine all of the physical evidence in the case, just as they get a call on a new double murder that looks suspiciously like the case they're working on.
With graduation quickly approaching, Flex's ex-wife Nicole (Tichina Arnold) convinces him to meddle in Breanna's love life, hoping she will choose a college in California over staying in Baltimore with Arnaz. Later, Arnaz tells Breanna that she should go to California to follow her dreams, but she thinks it's his way of breaking up with her.
After Darnell reveals that he has failed to get a band for his wedding (which is just two days away), Maya recommends that he hire Lynn's band. However, Lena is not impressed after hearing the group perform, and lashes out at Darnell. He turns around and blames Maya for the fight, accusing her of trying to sabotage the wedding. Darnell shows up at Maya's apartment drunk after the bachelor party and says that he loves her. Meanwhile, Lynn continues to battle her feelings of jealousy regarding Finn. William begins to complain about the restaurant, prompting Joan to suggest that he is actually dealing with issues about their break-up. After going into false labor, Toni vows to live life to its fullest in the short time left before she gives birth.
Gigi is pulled out of her depression when a call from her agent brings news of a job – a gig for a cable network movie shooting in the Rockies. Not realizing she is merely the movie’s required Canadian content, Gigi ventures north in search of a break from Los Angeles and her ex-boyfriend Payne. Her wish comes true when she meets (and beds) Bo, the Olympic bobsledder – only to find out later he’s an anti-Semite.
Ray fears getting his adenoids removed, but Debra convinces him to go through with the surgery. At the hospital, while Marie is in the bathroom, and everyone else in the waiting room, the nurse comes out and tells Debra that Ray isn't waking up from the anaesthesia.
Jack finds that his efforts to bargain with Marwan for the location of the missile strike are futile. Heller pushes his son for information when CTU discovers that he may have had contact with Marwan before the attacks. Logan finds himself in the middle of a power struggle between Palmer and the ambitious Speaker of the House. Tony and Michelle explore their rekindled passion for each other, but their hopes for the future may be short-lived when a familiar player enters the game and takes a hostage.
Flanders rents a room to two college girls who, without his knowledge, use the spare room to broadcast live softcore pornographic web videos of themselves. Upset that no one in town told him this (and that Homer was the one who told everyone), Ned moves to the seemingly perfect town of Humbleton, Pennsylvania, while a brash coach moves into Flanders' house and begins harassing Homer the same way Homer harassed Ned.
Bart gets expelled from school and transfers to a Catholic school, where a hip priest named Father Sean tries to convert Bart and Homer to Catholicism, which worries Marge when she believes that Catholics do not go to the same heaven as Protestants and discovers that Catholic women do not use birth control.
Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.
Unbeknownst to Lois, the boys enter her in the Mrs. Tri-County Pageant as a joke. When they overhear the other contestants remarking that Lois doesn't have a chance of winning, they plot to help their mother take the crown. Meanwhile, Malcolm is blackmailed into delivering love notes to a contestant for Herkabe, and Reese discovers that, according to the Mrs. Tri-County Pageant manual's scientific formula, he is beautiful.
Evelyn demands Jake spend a night at her place when she finds out he spent Spring Break with Judith's parents. Neither Alan nor Charlie are keen on the idea, but going to a bar after dropping off Jake quickly erases their concerns.
After Mort bowls a perfect game, and Quagmire gets a key to the city by performing CPR, Peter notices he has nothing to be proud of. He then attempts to achieve fame by setting the world's record for most nickels swallowed. However, a slight miscalculation leaves him blind with nickel poisoning.
Jarry worries that Bullock and George Hearst will side with Montana on the annexation issue and a showdown looms between Wu and Lee. Andy Cramed holds his first religious service, though he doesn't count on Tolliver's participation.
Meredith grows increasingly dissatisfied with the unknown details of Derek's life. Meanwhile, Alex treats Devo, a patient whose religious beliefs jeopardize her chances for recovery; Izzie contemplates reconnecting with her estranged mother; Zoey, a pregnant woman in her 40s who's been diagnosed with cancer, disagrees with Cristina's medical advice; and the interns are mystified by Cable, a patient who's being treated for seizures and who thinks he's psychic.
A reality show where a group of contestants are stranded in a remote location with little more than the clothes on their back. The lone survivor of this contest takes home a million dollars.
Jonsey's new gig as the production assistant for local cable access isn't moving his new ""film career"" forward as quickly as possible, so he decides to film his own, ""Prank T.V."". And the first victim - Nikki. Caitlin agrees to be an accomplice and convinces her to spend the day with her getting a girlie make-over. Nikki reluctantly agrees and endures her personal nightmare of a day - manicures, waxing, and the ultimate horror - bikini shopping - all to make Caitlin feel better about getting dumped by a guy she wasn't even dating. But what will Nikki do to them when she finds out she's been pranked?
When Stan forgets his anniversary, he arranges to have 20 hours of Francine's memory erased, but the CIA temp on duty accidentally erases 20 years. Francine, having reverted to her wild child days, moves into her old apartment with Hayley as a roommate, and ends up going to a festival with Hayley's boyfriend. Meanwhile, Steve asks a good-looking girl out, but needs his wingman, Roger, to "jump on a grenade" for him and date her ugly cousin.
Sue and the team investigate a bank robbery but this bank robbery becomes a little more interesting than the team expected. They find out that the bank they are investigating was robbed several years earlier. This time they learn that three girls have robbed the bank, which begins to seem strange to the team. When they robbed the bank they stole shoulder pads and one of the girls is the daughter of the president of the bank that was being robbed. Lucy has a mystery of for a long to figure out after her grandmother gives her a jewelry box. When the team opens the box to find out what it contains they are all very surprised at what falls out of the box. Lucy learns that the letters her grandmother kept were from her first love named Oscar. Sue and Lucy decide to track down Oscar because he still wants to see Lucy's grandmother. Lucy is shocked when her grandmother learns of her surprise.
Some new evidence comes to light in an old case that involves Dr. Macy. Jordan is placed in charge of the case that will either make or break Dr. Macy. Meanwhile, Woody is hot on the trail of a cop killer, and Woody finds himself looking down the barrel of a gun.