Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
When the colorful billionaire Fred Puterbaugh (guest star Jon Lovitz) returns to the Montecito, with new girlfriend singing star Ashanti (as herself), there is bound to be some great entertainment. But once Ed and Danny discover exactly what brought the incorrigible billionaire back to Vegas, an audacious performance is the least of their worries. Meanwhile, a beguilling magician uses his skills to help Ed catch a slippery thief. Elsewhere, Sam finds new meaning in the words 'feminine wiles' when a highroller's wife makes a visit to the casino spa.
An angry Ephram makes a bold move - and breaks his father's heart in the process - in an attempt to raise money for a plane ticket to Europe by selling his music equipment, except his piano, to "muscian" Jared and his band. Meanwhile, Nina can't quite put her finger on why Andy has been acting strangely of late, whereas a more perceptive Delia comes right out and asks her father whether he has feelings for Nina, and Bright's green-eyed monster makes an unexpected appearance when Hannah (Sarah Drew) goes to the prom with Topher (guest-star Lukas Behnken). Hannah becomes very upset when Bright insults her dress. Bright goes apartment hunting. Lastly, Rose begins her treatment at the hospital with Harold by her side.
A former high school football star is murdered at a reunion, the CSIs must find the killer. The victim was the big man on campus in high school and there are a lot of guests at the reunion with reasons to resent him all these years. Now, the team must investigate everyone, from the head cheerleader to the school misfit, to see who held a decade-old grudge big enough to kill. Meanwhile, Horatio and Delko arrive at a crime scene and discover that it's already been processed, leading Horatio to uncover further information about his brother possibly being alive.
After Flex hurts Danielle's feelings by teasing her for being fat in high school, he tries to make it up to her by recreating the prom she never got to attend. Meanwhile, after agreeing to let Spirit design her prom dress, Breanna is furious when she shows up to the prom in the dream dress she wanted to wear.
Toni is surprisingly excited about a visit from her mother, as she hopes to be pampered before having her baby. However, she soon learns that her mother actually came to town because she recently received a letter from an ""old friend""--and is considering having an affair with him. Meanwhile, William and Joan panic when J-Spot has trouble bringing in customers. They hope to correct this by giving the place an air of exclusivity.
CTU scrambles to forge an alibi when a Chinese representative produces evidence of American involvement in the raid on their embassy. Audrey gives Jack the cold shoulder, while Palmer and Logan clash over the consequences of Palmer's decisions. Jack and Curtis close in on Marwan as the countdown for the missile launch moves ahead.
Allison encounters a psychopathic doctor who raped and murdered numerous teenage girls years ago. After learning that an evil soul has been possessing people, she sets forth to stop it before a new victim is found. Meanwhile, Ariel's math teacher accuses her of cheating and Joe steps up to her defense.
Gigi’s desperate for work as her savings start to run low. It doesn’t help that yet another one of her past sexual partners is making it big in Hollywood. The envious thoughts and regrets begin to be too much and Gigi goes into a deep depression while she watches the Oscars® with her friends.
Hayley comes home from a Green Party rally with her hair dyed green, instigating a fight with Stan. While she's sleeping, Stan cuts her hair (for her own good, of course). After learning of what Stan did, a wigged Hayley defies her father yet again by moving into the van of her new boyfriend. When Stan cuts her off financially, she gets a job as a waitress in a strip club, which pushes Stan right off the edge. Meanwhile, Steve tries to pass Roger off as his disfigured sister in order to cop a feel with a female classmate.
Sue meets a woman who says she saw a murder but the only problem is there are sure whether Beth heard or saw the murder. Sue and Jack find out that their witness is schizophrenic and gives them clues in strange metaphors making the case all the more complicated to figure out. Also the team gets a new acting supervisor named Wayne. Their new supervisor begins to drive them crazy when one begins to color code all their cases. He places the current case as a low priority case. They soon find out that Wayne has never even solved an FBI case in his life.
Jonesy becomes the manager of a guru. When the guru is unable to come to the mall for his speech, Jonesy gets Jude to take his place. Jude gives people his ridiculous advice, leading to catastrophic events with Wyatt stuck up a ladder when he is afraid of heights.
Unbeknownst to the sisters, baby Wyatt's new ""imaginary"" friend is actually a demon named Vicus who is trying to win Wyatt's trust to turn him evil. Meanwhile, Piper casts a spell to be able to understand baby Wyatt, but inadvertently brings 25-year-old Wyatt back from the future.
Nigel is spending the evening with his new soul mate when her daughter ends up kidnapped. Nigel is left with questions that science cannot answer. A man thought to be dead awakens on the autopsy table…scaring Lily.
When an old truck containing human bones is pulled from the Delaware River, the team re-opens the case of a missing and possibly murdered girl who disappeared unexpectedly in 1932.
Hank talks Bobby into joining the track team, but the spot the boy lands isn't what Hank had in mind.
Homer sees a movie about the end of the world and fears the same thing will happen in real life after seeing a chain of random occurrences (celebrities ["stars"] falling from the sky, raining blood, a man in a realistic devil costume) and doing a complicated math equation that predicts the end will come on May 18th, but when the end does not come, Homer discovers a flaw in the equation and ends up in Heaven where he meets God and learns that God is planning The Rapture.
Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.
Lisa agrees to enter a Krusty-sponsored "Li'l Starmaker" competition and panics when another contestant (guest voice Fantasia Barrino) outperforms her.
Derek and Meredith try (unsuccessfully) to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to everyone - including Bailey, who warns Meredith to end the relationship. Meanwhile George suspects an anesthesiologist of drinking on the job but is reluctant to speak up about it, Alex treats a former competitor who now finds honor in self-mutilation, Izzie has to deal with a patient who won't let go of his girlfriend - literally, and Cristina seems to be battling a case of the flu.