Krypto gets amnesia due to red kryptonite and can't remember who he is. The Junkyard Dogs try to turn him into a bad dog.
Michael tries to leave for a golfing trip with a friend, but the family keeps distracting him.
When a classmate's boyfriend threatens to post a humiliating video of the girl online if she dumps him, Veronica helps her concoct a scheme to ensure "mutually assured destruction" if he doesn't allow the relationship to end peacefully. Meanwhile, Keith begins to search for Duncan after his parents post a huge reward for information on his whereabouts. Later, as her secret new relationship heats up, Veronica learns a disturbing new fact about the night that she was drugged and assaulted.
Elliot is torn between moving too quickly and ruining her new relationship with Jake. Dr. Cox teaches Turk about having a healthy ego and Dr. Kelso and the Janitor fight over who gets to use the motorized cart.
Just as Monica and Vic get close to a big break in the Garage Sting, Chief Phillips unexpectedly hands over the bust to the Organized Crime Unit. He blames the decision on an emerging PR scandal involving a videotape of Vic at the church bust that was leaked to the Assistant Chief through Aceveda's office. Vic uses his leverage with the Byz Lats to find a Russian mob leader before the mobster flees the country. Monica threatens two foster care social workers with jail after a young girl is found close to death in her foster home, then tells Julien if he doesn't put in for a transfer, she'll request one for him herself.
When Rory tells her beau she can't have a casual relationship with him, he gives her an unexpected response. Sookie finds herself confined to her bed.
After a marine is murdered in the school campus the team discovers a possible suspect for his murder, but they are soon leaded back to zero point when they find the suspect murdered. Tim & Abby discover a trace to a ""Red Cell"" in the e-mails and the team believes that maybe the marine was involved in a serious game...
A woman who comes to the office to sell purses gets the male members of staff excited. She rejects Dwight's advances, but Michael reckons he's still in with a chance.
Chloe is unexpectedly thrust into fieldwork when a woman reports that her boyfriend may be part of the terrorist conspiracy. Jack and Curtis find their latest efforts to trap Marwan thwarted by the Secret Service, who have orders to arrest Jack for insubordination. Mike calls on ex-President David Palmer for help as Logan continues to display a lack of leadership.
Evidence shows that a pilot is indeed guilty of his wife's murder. However, in Allison’s dream, when the pilot is put in jail, there is a plane crash where hundreds of people are killed. Should Allison put forth the evidence to land this guilty man in jail, or let him go free in order to save hundreds of innocent lives?
Streaky accidently gets the power of invisibility. However, he soon learns the about the problems it causes.
After returning from New York feeling lost and confused and needing Amy for support, Ephram considers his options in the wake of Madison's (Sarah Lancaster, who does not appear in this episode) life-altering revelation. Ephram tries to find the baby by going to Child Services Office, but finds out that Madison signed the adoption papers with "father unknown" and terminating the parent-child relationship with "Unknown Birth Father" leaving Ephram completely crushed. Amy tries to get Ephram another audition at Julliard after he missed his first appointment due to the emergency with Madison and the baby, but it doesn't go well. Meanwhile, a tired Andy is a little stunned upon learning the extent of Nina's feelings for Jake and with a little encouragement from her friend Bright, Hannah decides to go on a date with a smitten Topher (guest-star Lukas Behnken).
Jabari becomes extremely sullen and disrespectful, and begins talking back to his parents. After he runs away from Joan's house while she is watching him, Maya and Darnell finally learn the source of Jabari's anger: he is upset over Darnell's engagement because he wants his parents to reunite. Maya and Darnell struggle over what to do about their son's despair. Meanwhile, Lynn and Toni refuse to believe that William's depression stems from his car's inability to pass a smog test. They insist that he is actually upset about the break-up with Joan, and pressure him to share his feelings.
Ed suspects that the Montecito's security system has been breached and that he and his hotel staff are now under surveillance, Danny and Mike are employed to expose the identity of the phantom mole. Meanwhile, Sam is seduced by a high-rolling vampire when he mysteriously appears in her room. Elsewhere, DeLinda escorts her sheepishly innocent Amish cousin as he sows his oats on the Vegas strip before returning to the simple life.
After Mona complains about being bombarded with demos and Spencer's refusal to pay back his debts, Dee Dee encourages her to become more assertive and not let people take advantage of her. Mona follows her advice and re-possesses Spencer's new jacket and shoes. However, Dee Dee's words come back to haunt her when her sister refuses to listen to a demo by Dee Dee's handsome and influential new boyfriend. Meanwhile, Phyllis enjoys being pampered at an expensive shoe store after a salesgirl mistakes her for Big Dee Dee.
After losing her mother, her relationship, and her career all in the same year, Gigi leaves Canada to resume her life in Los Angeles. However, her intentions to reinvent her love life and career are quickly deterred when she is barred from a red carpet premiere, and sees her ex-boyfriend Payne kissing his new lady. But when her pals come together for the anniversary of her mom's death – coincidentally, on Valentine’s Day– Gigi is reminded that she's not out of the game yet.
Christine wants to make new friends after she overhears Kim telling Greg that she and Jimmy have been spending too much time over at the Warner house instead of their own. Meanwhile, Greg and Kim make new friends that they want to get rid of.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.