Sydney and Vaughn tell Jack about Sloane's alleged involvement in Vaughn's search for his father and Irina's contract on Sydney's life. After cornering Sloane, they both conclude that someone is framing him. The APO team set a trap to catch the fake A. Sloane, but they fail. Once they realize what "Arvin Clone" is after, Sloane suggests he should step down temporarily. However, Sydney reluctantly convinces him to stay on the case, since he may the only person able to anticipate "Arvin Clone's" next move. But Nadia fears that this pursuit may revive her father's past obsession – Rambaldi.
As Eric moves out of their apartment and into one across the courtyard, Alex plants herself up in Joey's room with a pair of binoculars as Eric invites another woman over. After Alex goes to bed, Joey sees Eric kissing the other woman. Meanwhile, Joey's got problems of his own: even though he and Sara are allowed to see other people, he's not because he's too crazy about Sara. Trying to make her jealous, Joey discovers that she likes him as much as he likes her, and they decide not to see other people.
On the eve of the Smallville High School Prom, stuck-up candidate for Prom Queen Dawn Stiles is pulled into a coma when she is involved in a car crash into a ravine filled with dozens of chunks of kryptonite. While her body lies in a coma, Dawn finds her spirit allowed to possess the bodies of others, where she can continue her quest to become Prom Queen. As a result, Martha, her body possessed by Dawn, flirts with Clark and asks him to the Prom, Lana attempts to electrocute the ex-boyfriend who dumped Dawn, Lois goes all-out to ensure she and Clark go to Prom together, and Chloe attempts to set fire to the school on Prom night.
All the kids are getting ready for the big South Park Elementary Talent Show and Jimmy can’t wait to perform his new comedy routines. But lately, just like generations of little boys before him, Jimmy’s noticed that one of his body parts has a mind of its own. Knowing he can’t get up in front of the entire school in an excited state, Jimmy must find a way to gain control of his raging hormones in time to perform in the show.
A work event in a ballpark skybox leads Carrie, Doug and his buddies out to the game - but when an important client finds fault with Doug, Spence has to step in as the devoted husband. At Arthur's dinner party, guest Bernard, turns the table against him.
Red kryptonite causes Krypto's tail to detach from his body.
Sam and Alex confront Clover about slacking off during their missions. After losing track of Clover on their next mission, they find she has single-handedly defeated the villain. Suddenly, Clover is acting differently. Her spy skills keep getting better and better. When Sam and Alex investigate, they find out that Geraldine, head of rival agency S.P.I., has secretly modified Clover into a super agent so she can recruit her. In the climax, it's Sam and Alex versus the super agent Clover to try and get their best friend back. In a b-story, Clover's busy social life is interrupted when she becomes a super agent.
The team's plan to con an auction house with a comic book forgery goes awry when corrupt copper, Sam Phillips (played by Fay Ripley), decides she wants in on the play.
Catwoman's cat, Isis, steals a cursed gem that causes Ace to run into a string of bad luck.
Jim, certain he will win the annual hot dog eating contest, is humiliated when instead he loses to a petit woman (Suzy Nakamura), and his problems are further compounded when Andy decides to date the female champion.
While helping her classmate Mandy search for her missing Jack Russell terrier, Veronica stumbles onto a bigger mystery, which affects pets all over Neptune. Meanwhile, tensions mount in the Echolls family as Trina tries to convince the now-retired Aaron to take a part in her new boyfriend's independent movie. Later, Weevil is arrested for breaking into the Kane residence and taking something from Lilly's room.
House and his team battle to diagnose a pregnant patient's life-threatening illness, prompting her to make the most emotional decision of her life, and Vogler is determined to fire House.
Luke helps turn an old house into a museum. Lorelai says too much during an interview about the inn. Rory, Paris and Lane have boyfriend trouble.
Vic and Monica stake a deal with the DEA to shut down Mitchell's tar heroin operation. When the bust comes up empty, Vic's suspicions of Shane grow, until Shane proves himself by coming up with a key piece of evidence that reveals a large stash of tar being stored at a local church. Meanwhile, Dutch and Claudette's friendship continues to feel strain as they try to tie a young woman's murder to a suspected serial killer. Plus, Julien takes a stand against Monica's policy, then goes to David for support when she suggests he consider transferring out of Farmington.
Turk won't open up at couples therapy. Elliot refuses Dr. Cox's romantic advice, when a very attractive man saunters into the hospital. J.D. learns a lesson in humanity from a dying old woman. The Janitor accidently lets a bunch of rats run around Sacred Heart.
The office staff play a basketball game against the warehouse workers in which Jim shows off to impress Pam and upstage her fiancee who is on the opposing team.
Keith gets violent with Dan after learning that Dan paid Jules to fall in love with Keith. Anna turns Felix in to the school authorities after learning that he was the one who vandalized Peyton's locker. Lucas and Brooke discuss Brooke's possible move. Meanwhile, Nathan chances Haley in the hope of bringing her home. Brooke decides to move in with Karen.
Streaky programs Dogbot to help Krypto so he can have more time with Kevin.
On the morning of his Julliard audition in New York, Ephram makes plans to meet up with Madison (guest star Sarah Lancaster) for coffee where he finds out that she was pregnant with his child. This devastating revelation causes Ephram to make decisions that will alter the course of his life. Amy tries to figure out what this will do to her and Emphram's relationship. Meanwhile, Dr. Abbott counsels a man (guest star Chris Penn) whose son may die as a result of a hunting accident.
Horatio's life is changed forever when he learns important information about his deceased brother. Horatio must now figure out what to do with this information about his brother, Raymond, and whether or not to tell Yelina. Meanwhile, the team investigates when a woman is murdered at a crowded bar after she's approached by a female employee of a service that helps men pick-up women. Also, when Delko loses his badge after some reckless behavior and it's used in a crime, he must locate the badge before it's used again.