Gob hides George Sr. while the model home's plumbing is checked; George Michael helps Ann protest Maeby's new movie; Tobias takes a liking to Kitty after Michael asks him to keep an eye on her.
Through Professor Frink's future machine, Bart and Lisa see their lives in the year 2013, where Bart steals Lisa's chances at going to an Ivy League school in order to impress a skater girl named Jenda while Homer (now separated from Marge and living in an underwater apartment) fights Krusty the Clown after Marge begins dating him.
Lois goes over to visit Ida, but gets unpleasantly surprised by the St. Grotus Day festival. Malcolm fails a music appreciation course, and reluctantly goes to Dewey for help. Reese and Hal secretly watch scary movies while Lois is not around, but it ends up revealing some unexpected secrets about both Reese and Hal.
While George is feeling a little less masculine because of the way Izzie and Meredith have been treating him (like a sister), Izzie is assigned to a patient about to loose all of his masculinity. Cristina, true to her competitive spirit, shows up early and assigns herself to an ill woman, who happens to have been Meredith's moms scrub nurse. Alex, meanwhile, is busying himself copying and pasting pictures of Izzie's racy magazine spread all over the interns' locker room. And while Meredith is trying to cope with her mother's Alzheimer's, Derek treats a patient who has managed to get nails stuck in his head.
Alma and Bullock discuss the camp's financial future. Swearengen shares news about an important visitor. Wolcott seeks to make a deal with Utter involving Wild Bill Hickok's last letter. Tolliver relies on Lee's expertise.
The school dance committee implements an experimental personality-based partner selection process. So, Chase tries to get matched up with Zoey, and so he does whatever it takes to get matched up with her. But of course, his plan backfires when another guy gets matched up with her as well as him. Zoey must pick between Chase and Glen, the other guy. Chase is upset and tries to get Zoey to pick him.
Dale dons a disguise to defy Arlen's smoking ban, and Peggy sets out to uncover his identity.
The boys get out of jail only to find that Cory and Trevor messed up again and they don't own the park after all. Ray is hooked on VLTs.
Dana is stunned when Alice requests a bold sexual favor from her. Burr Connor (guest star Tony Goldwyn) reveals a secret to Jenny. Jenny learns about Carmen's real feelings for Shane, Kit plans a romantic night for Benjamin, and Bette and Tina have an intimate encounter as they bond over their unborn baby.
Josh's e-pal, Yooka, is coming from Yudonia to visit Josh. Drake doesn't care about her at first, but then he sees how hot she is. Josh overhears Yooka telling her parents she is homesick, so he arranges what he thinks is a friendship ceremony but is really a marriage ceremony.
Splinter receives a vision of his Master Yoshi...and a mission. He must stop the Shredder. Time is running out. He doesn't know how to explain it to his sons, but they need no explanation. They're with their father to the bitter end.
After the Warriors befriend a mermaid trapped in ice that's being hunted by an ancient warrior, they soon discover that the warrior and mermaid aren't exactly what each appears to be.
Hot Shot and the Autobots battle Ransack and Crumplezone in the first round, while Starscream continues to build his forces when he recruits Mudflap and Lori and Bud uncover information on the Ancients' prehistoric visit to Earth.
The gang investigate the International Sand Building Competition where a strange coral monster has appeared from the Great Barrier Reef to scare the contestants.
Rose is taken home, but a spaceship crashes in the Thames and London is closed off... Enter the Slitheen!
The city is in a panic as a sniper goes on a shooting spree and randomly kills several people, including a postal worker. The investigation reveals that more than one shooter is at work. As Charlie works the case, he's frustrated by a sniper expert Don brings in to help out.
Joan and Grace fear the worst when, on the heels of failed attempts to reconnect with Joan, the emotionally fragile Adam goes missing during a hike... Despite Grace's attempts to foster a more comfortable rapport between her friends, Joan is intent on hurting Adam with her rebuffs, which she regrets when it appears that his life may be in danger. Meanwhile, Helen is shocked when a priest tells her that the man who raped her 25 years ago would like her to visit his deathbed so he may apologize. Also, Luke is dismayed and intrigued when he learns that Friedman has been getting stoned.
To contact the spirit of the previous Avatar, Aang must reach a temple in the Fire Nation before the sun sets on the following day. There he will learn what he must do to restore balance to the world. Zuko must defy his banishment to follow Aang.
As Trance's sun closes on Seefra-9, Rommie is rebuilt by Doyle to help evacuate the planet.
After C.J. discovers that Cate may be starting a relationship with Principal Gibb, he blabs it to Bridget. An angry Cate has Gibb put C.J. in charge of the student detention on Ditch Day, and C.J. gets even by detaining Bridget. Because she is stuck in detention and can't complete the Ditch Day prank herself, Bridget convinces Kerry and Rory to steal the rival school's mascot.