House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.
Michael arranges a morale-boosting birthday party for Meredith and is determined to come up with the funniest message in her card. Dwight wants a pact with Jim to fight the downsizing, and Michael regrets showing off when Oscar asks for sponsorship for a charity walk being undertaken by his nephew, who has cerebral palsy.
Jim and Cheryl adjust the clocks to get the kids to bed earlier so they can have more quality time together.
The whole school has caught Yu-Gotta-Go fever, a role playing card game, except Chuckie. When he finally starts playing, it becomes an obsession, and he's hired by Angelica to do her chores in exchange for more cards. He becomes one of the school's elite players, but in the pursuit of an elusive card, he nearly parts with the valuable stamp collection that Chas has passed down to him. It's up to his friends to keep him from getting in over his head.
George gets caught up in some bad family ties when he lets Vic give him money to go out on a date with his sister.
When Jr. wins a national competition for his cartoon entitled ""My Wife and Kid"" -- based on himself, Vanessa, the baby and the rest of the Kyle family -- it catches the attention of ABC. Michael becomes Jr.'s agent, but the meeting with the television executives goes badly, crushing Jr.'s dream opportunity, so now Michael has to find a way to rectify the situation. Meanwhile, Claire threatens to break up with Tony unless he can bring some ""umph"" into their relationship.
Mike pushes for the Vice-President to be sworn into office as the White House waits for news of Keeler's fate. Two innocent bystanders are dragged into the fight as Jack and Marwan both pursue a briefcase that contains the launch codes for America's nuclear arsenal.
An IRS agent is killed while trying to repossess a delinquent taxpayer's yacht soon after the CSIs discover a second IRS agent shot to death. Now, just when everyone has a reason to detest the IRS, Horatio must find who is behind what could possibly be a series of murders right before tax day.
Kevin learns to take it easy on dogs, even if they have super-powers like Krypto, when he becomes a pet for a giant male dog.
When Alice runs into her ex, she is surprised to find out that she is now dating Dana's ex-girlfriend. Bette and Tina reach an agreement over their relationship, Jenny is worried that she may have lost a writing job, and Shane finds some comfort in a church.
When Lisa Ross is brought into the emergency room with a severe case of cloracne, suspicion quickly turns to her husband Greg, a well-known dentist, especially after she dies. During their investigation, Goren and Eames hear whispers about Lisa's infidelities, but the real break comes with they learn that Lisa is not the first woman Greg Ross has been connected to who died of the same symptoms years earlier. After discovering Lisa's connection to Greg's former fiancée Morgan Dexler, Goren and Eames believe they have the answer, but they're not there yet.
Susan's mom pays an unannounced visit to Wisteria Lane after she and her boyfriend call it quits. Meanwhile, Gabrielle faces Carlos' wrath after he learns about the hospital settlement and tries to change their prenuptial agreement in order to keep Gabrielle in check while he serves his jail sentence. Lynette and Bree experience a chill in their friendship after Bree babysits Lynette's kids and dares to discipline Porter. Also, Bree and Rex visit Andrew at the teen rehab camp where they learn some shocking news about their son. Lastly, Felicia gets closer to Zach and reveals some disturbing details about his family in the past.
Gob confronts the editor of the videos that showcased his magic mistakes. Michael tricks Lucille in to rehab, and then attempts to get her out after George Sr. is kidnapped.
Merrick gives a schoolteacher a tour of the camp. An influx of Chinese labor enters the workforce. Swearengen is finally able to honor appointments. Alma suggests the idea of a bank; and Bullock insults the owner of a gold claim.
A bike race injures several pedestrians as well as well as participants. One pedestrian is left brain dead. Christina and Issie wish to use his organs for organ donation but with Christina's detachment and Issie's ever hopeful attitude that the man will recover, they will find the organ harvesting process an emotional one. Preston faces feelings of his dislike of organ harvesting - as a surgeon, he likes saving lives; harvesting organs doesn't save the person's life. George deals with Mac, a friend of the chief, who won't stop flirting with him. He is in need of a new liver. Meredith is fed up with Alex showing off as she continues trying to push Derek away. She also is reaching the limits of Issie's sunshine and George's politeness as she goes on living with them. Then there is their desire to see Meredith's mother's medical tapes. Getting through the day, Meredith realizes the keys to winning the race.
Malcolm discovers a man, Norm, living in the Lucky Aide. He agrees to keep Norm's secret as long as he provides Malcolm with tidbits on his new crush, a fellow Lucky Aide employee. Meanwhile, when Reese takes a job as an exterminator, he quickly learns that to drum up business he must infest the neighbors' lawns, and chooses caterpillars as his weapon. But instead of spreading the caterpillars, he has a change of heart and begins to nurture them, ultimately leading to his own menagerie of butterflies.
When a convicted killer is set to be released from prison Woody, Dr. Macy and Jordan race the clock to turn up new evidence. Jordan must decide how far she will go for this case…as she takes the stand for the prosecution.
In this episode the gang is worn out from always running in gym class. Nicole keeps throwing up and is tired of it. To solve this, they decide to put together a disc golf team to keep them from doing gym class. Also, Michael is not happy with his weight due to him being addicted to chips, so he gets Quinn to solve his problem