In an attempt to talk to Sydney, Katya Derevko deliberately poisons herself and is temporally taken out from her cell. Once Nadia tells her sister about this, Sydney visits her aunt to tell her to stay away from Nadia. However, Katya unsettles Sydney by telling her that someone framed her mother as a means of getting her killed. Sydney sets off in search of the truth behind this story. Meanwhile, Vaughn becomes a rogue agent by getting involved with the people who might know his father's whereabouts. In the end, he and Sydney find out that the man behind these two plots is no other than A. Sloane. However, things are not exactly as they seem to be.
When the body of a young woman is discovered at a laundry facility, the bed sheets she is wrapped in lead Mac and Stella back to an upscale New York hotel that houses diplomats from around the world when the United Nations is in special session. Meanwhile, Danny and Aiden investigate the death of a homeless man found dressed as a human statue. By all accounts, the prank is deemed a misdemeanor, but Danny decides to delve further and his refusal to stop the investigation puts him at odds with Mac.
The bludgeoned corpse of a promiscuous lawyer is found in her office and detectives treat her former lovers as suspects until DNA evidence points to a co-worker. This crossover continues on Law & Order: Trial By Jury S01E08 Skeleton (II).
The team investigates a suicide case, believing that the main reason of her death is a nervous breakdown, but Ducky believes that she was actually murdered. FBI Special Agent Fornell helps them in the investigation. The team discovers that the dead woman was involved in a love triangle and that this may have contributed to her death.
The whole school has caught Yu-Gotta-Go fever, a role playing card game, except Chuckie. When he finally starts playing, it becomes an obsession, and he's hired by Angelica to do her chores in exchange for more cards. He becomes one of the school's elite players, but in the pursuit of an elusive card, he nearly parts with the valuable stamp collection that Chas has passed down to him. It's up to his friends to keep him from getting in over his head.
A series of fire drills leads Veronica to discover that Neptune High has been receiving bomb threats, so she enlists Wallace and Mac's help to investigate classmates who could pose a serious threat to the school, including new student Ben. Meanwhile, Keith stuns Veronica with the news of who he's been secretly dating. Later, Duncan confronts Veronica about her ongoing investigation into his sister's death.
J.D. and Carla get the silent treatment from Turk, who can't seem to control his emotions, after learning about their kiss. Dr. Cox reluctantly seeks the help of Elliot, when an epileptic patient won't listen to him. The Janitor feels emasculated by his new uniform. Jordan trys Botox.
A tip from Lemonhead's juvie would leads Vic and Monica to take down a major heroin operation with connections to Antwon Mitchell. Monica continues to battle Aceveda as she tries to sell her new policies to the community, and Julien begins to doubt her methods. Claudette loses trust in Dutch when she suspects he made a backroom deal with the D.A. And Shane and Army find themselves over their heads with Antwon when he blames them for Vic's heroin bust.
House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.
Michael arranges a morale-boosting birthday party for Meredith and is determined to come up with the funniest message in her card. Dwight wants a pact with Jim to fight the downsizing, and Michael regrets showing off when Oscar asks for sponsorship for a charity walk being undertaken by his nephew, who has cerebral palsy.
Jim and Cheryl adjust the clocks to get the kids to bed earlier so they can have more quality time together.
Danny has found a potential new member of the gang, Trevor (played by Lee Ingleby). He's a short con artist, who's very good at what he does, but his marks are not always the greedy; he also targets the elderly and the poor...
When Krypto is rendered powerless by the effects of red kryptonite, Ace the Bat Hound gives him a bat collar so they can track down the Penguin's birds.
George gets caught up in some bad family ties when he lets Vic give him money to go out on a date with his sister.
When Jr. wins a national competition for his cartoon entitled ""My Wife and Kid"" -- based on himself, Vanessa, the baby and the rest of the Kyle family -- it catches the attention of ABC. Michael becomes Jr.'s agent, but the meeting with the television executives goes badly, crushing Jr.'s dream opportunity, so now Michael has to find a way to rectify the situation. Meanwhile, Claire threatens to break up with Tony unless he can bring some ""umph"" into their relationship.
An IRS agent is killed while trying to repossess a delinquent taxpayer's yacht soon after the CSIs discover a second IRS agent shot to death. Now, just when everyone has a reason to detest the IRS, Horatio must find who is behind what could possibly be a series of murders right before tax day.
Mike pushes for the Vice-President to be sworn into office as the White House waits for news of Keeler's fate. Two innocent bystanders are dragged into the fight as Jack and Marwan both pursue a briefcase that contains the launch codes for America's nuclear arsenal.
Kevin learns to take it easy on dogs, even if they have super-powers like Krypto, when he becomes a pet for a giant male dog.
Every year Caitlin is chosen in a contest to represent The Khaki Barn and win a free wardrobe. This year, her longtime ""frienemy"" Tricia is NOT going to let it happen so she enters too. When the contest comes to an end, the Khaki Barn rep. cannot choose between Caitlin and Tricia and Tricia challenges Caitlin to a shop off, winner takes all, so of course Caitlin accepts. It looks like Caitlin is about to win, but Tricia trips her as she's swapping bags and Caitlin is disqualified. While that is happening, Jonesy is running a new food booth in the food court called ""Roast Burky Chunklets"" and with help from Jude, Jonesy forgets to refrigerate the meat, and everybody except Caitlin experiences food poisoning, including Tricia. Because of this, Caitlin is crowned the new Khaki Girl.