The six-year on-again, off-again relationship between Robert and Amy is reaching a pivotal moment. Robert wants to propose to Amy, but there's one small formality the hopeful groom-to-be must take care of first: asking Amy's devout churchgoing parents for their daughter's hand in marriage.
On a church ski trip chaperoned by perpetual party pooper Dr. Abbott, Amy and Colin share their first kiss since the surgery. Ephram finds himself intrigued by Colin's younger sister, Laynie (guest star Nora Zehetner), who has recently returned home from boarding school. Also, Bright attempts to get to the next base with his girlfriend (guest star Devon Reilly). Meanwhile, Andy hesitantly agrees to attend a singles mixer with the recently divorced Reverend Keyes (guest star Tim Dekay).
A nude man is found tied to his bed, having suffocated on a rag stuffed in his mouth while he was being sexually assaulted. Meanwhile, while investigating the murder of a crematorium owner, the CSIs discover dozens of bodies that were never cremated.
Spencer thinks that he has gotten a girl pregant and Dee Dee and Mona force him to get an AIDS test.
Flex's little sister, Bernadette has come to Baltimore to announce to her brother that she has given up her sucessful career in law to become a fashion model. Flex tries to figure out how to break the news to their dad. Meanwhile when Breanna gets a baby from her Home Economics class Josh and Arnaz become competitive to be it's father.
Maya befriends a fellow single mother, a janitor at the law firm's building. They quickly make a connection, but Joan finds the woman's attitude irritating; and fears that her example could negatively impact Maya's relationship with Darnell. Meanwhile, William pretends to work at Lynn's office because he misses the camaraderie of a workplace; and Lynn tries to scam her co-workers out of money by pretending it's her birthday.
Nikki's efforts to get a loan are sidetracked when she and Professor Oglevee are taken hostage during a bank heist staged by a little person.
The morgue staff gathers to attempt to try and solve a case from 1964. With each of the staff members assuming a role in the case, with Max leading the way. Will they be able to find a killer from so long ago?
"Okay, that did not work," Trance says. "Let's try again." Trance tries to figure out how to help the crew survive a deadly intruder.
Eric tries to help Chandler after the young minister learns that his father is dying of lung cancer, but Chandler rejects Eric's aid and pushes him away. Lucy accepts a date with Chandler's chain-smoking tattooed brother Sid in order to make Kevin jealous enough to propose to her. Elsewhere, Annie is shocked when she finds a pack of cigarettes in Simon's bedroom. Lastly, Ruthie's friend Peter begs her to lie and not tell his mother that he smokes.
Ellenor continues her desperate attempt to stop the execution of a mentally ill woman Denise Freeman on death row. The firm is torn over a controversial settlement in their case against an alcohol company.
The team races against time to find a crate of strontium which they believe will be used to make a dirty bomb. Lucy fears for her family when they are coming to her sister's wedding.
In the aftermath of his confession to Beth, JJ struggles to put their relationship back together again, but quickly realizes that it might be too little too late. Elsewhere, Meg strikes up a musical friendship with Sam as they decide to save money by sharing records - causing problems with JJ who quickly reminds his sister about the trouble she faced after her previous interactions with Sam. Meanwhile, Jack entrusts his new employee -- Nathan, the nephew of Henry with delivery duty, but later questions his decision when Nathan fails to return. Helen volunteers to baby-sit for her professor and gets to know him better while Roxanne fights for a coveted position writing the ""Backstage on Bandstand"" column for Teenzine magazine.
Grandma Ida is even nastier than usual (if that's possible) because of a tumble down the front steps that resulted in a broken collarbone, prompting her to sue her daughter and son-in-law for pain and suffering. And there's more momentous news on the home front: Lois is pregnant.
After the tyrannical owner of a Manhattan luxury hotel is found submerged in her bathtub, evidence seems increasingly to indicate that the woman's death was the work of her deeply frustrated, long-suffering daughter.
Sydney, Vaughn and Jack must determine whether CIA agent Lennox is who he says he is after his deep cover mission is compromised.
Glen returns to Paige's life with a big surprise - he is about to get married to a girl called Jessica. Meanwhile, the sisters summon a Witch Doctor whom they want to dispatch all the evil remnants that surround the Manor.
Johnny takes on a major corporation to prevent the mass marketing of a drug he foresees will cause terrible birth defects years down the line.
Dr. John Becker goes through his daily routine of being a doctor, stopping at his favorite diner, and other various situations, all the while hating life and everything around him.
Everyone has a different opinion of new inmate Idzik; Alvarez receives shocking news; Redding's attempts at reform continue; Murphy makes a confession to Glynn; Morales'(David Zayas) medical suspicions are confirmed; and Beecher's devotion to Keller leads him into a perilous position.