A reluctant Susan accepts Lynette's offer to be baby Paige's nanny; Bree meets Keith's parents; Renee makes a proposal that Lynette can't refuse; Gaby fears that Bob might be trying to seduce Carlos after they become friends; and Beth begins to question Paul's motives for returning to Wisteria Lane.
Bo's freelance work earns her a lead on someone who might know something about her mother... but the trail ends at Lou Ann, a death row inmate who claims not to know anything at all. Desperate to prove otherwise, and increasingly convinced Lou Ann is innocent, Bo uses all her Fae connections to try and bust her out of jail. When she has to admit defeat, Bo's goal switches to one of personal vengeance: to find Vex, the Fae that framed Lou Ann, and make him pay.
Worried about the effects of violent video games, Marge encourages Bart and Milhouse to play board games; Lisa becomes smitten with a new student, a vampire; while on a second honeymoon, Homer and Marge rescue a castaway who escaped from his ship.
When Skipper is knocked on the head, he's unable to lead the penguins on an important mission.
Nucky visits Chicago for the Republican National Convention, where he finds himself intrigued by the candidacy of Warren G. Harding over more established candidates. The D'Alessio gang moves in on Nucky's territory at the expense of Eli, who has been watching over his brother's affairs. Margaret finds herself entangled in Nucky's business affairs, while Van Alden struggles with his wife's desire for a child. Rothstein prepares for legal trouble over his role in fixing the 1919 World Series. Nucky asks Jimmy to return to Atlantic City to reinforce his position.
Wanting to have the scariest haunted house on the block, Stan comes up with a ''killer'' setup; Steve competes to win the heart of his overprotective friend's younger sister.
Dexter is called to investigate a horrifying crime scene; the Santa Muerte case leads to a violent standoff between Debra and the Santa Muerte killers.
Peter and Joe team up to execute a series of painful and humiliating Halloween pranks on unsuspecting family, friends and neighbors. While Brian shows Stewie the ropes of trick-or-treating, Meg sets out to attend her first high school Halloween party with high hopes for the evening.
Cora's pregnancy throws the inheritance issue into doubt. Matthew must wait for an answer to his wedding proposal. O'Brien discovers more compromising information about Bates. Thomas leaves.
Best friends CeCe and Rocky audition for the show, "Shake it Up Chicago". Unfortunately, CeCe did not get it because she froze in the middle of her audition (she usually pictures everyone else naked that is why she is never nervous). Rocky did well and got in. Rocky did not want to go to the show because CeCe was not on it. CeCe forces Rocky to go to the show. On Rocky's first show, she brought CeCe and handcuffed each other, and they ended up dancing together. The host thought that they have the "it" factor so, CeCe got in as well. In the end, the girls get $40 each but only $2 was left for them because they had to pay for new handcuffs, thrift store dance clothes, and transportation.
Jay Leno and Dr. Phil guest star as themselves when international superstar Hannah Montana contemplates removing her blond wig and telling the world she's really Miley Stewart.
Tim enlists Amy to ride Lightning Dexter in a big time stakes race when he finds out his girlfriend, Janice, has teamed up with the competition
Things are awkward for Jason, Lacey and Vanessa on the morning after. Lacey confesses her threesome to Marilyn, who thinks she is crazy. Marilyn has an offer to write for the Times but is worried about Cormac's reaction. Nicole and Richard spend a day together which leads to a fun night. Cody and Joanne, who has been hired as Stephanie's replacement, resume an old affair. Jason and Lacey stumble upon Vanessa and Rena making love in the loft.
The school is taken over by the demon sisters, Scanty and Kneesocks (the daughters of the mayor), and Panty and Stocking aren't pleased with the new changes they have made. In order to get their revenge, they team up with a Loser Ghost, who leads them to an underground factory where the demon sisters are producing Fake Ghosts. Whilst Brief escapes with the Ghoststone powering the factory, Panty and Stocking fight against the demons sisters.
Slowly going insane in prison, Doctor Doom leads an escape plan where he distracts the Super Hero Squad using a Fin Fang Foom balloon and must lead his former allies (and two new ones) to escape from the grasp of Captain America and Ms. Marvel.
The penguins must stop a contractor from completing repairs on their habitat before he destroys the world!