Section 13 sends its best Agent, Taggart McStone to stop Dr. Necrosis. Jade stows away and accompanies him on his mission, sending Jackie after them.
Breanna's mother comes to town for Thanksgiving. Flex at first disagrees, but he soon falls in love with her again. They make love and the next day Breanna catches them thinking that her parent's are coming back together again. Later they attend Breanna's football game and after that they started arguing, so Breanna has some second thoughts about this parents together thing.
Nikki is stunned by a revelation about her Aunt Rita when the entire family appears on a game show that exploits family secrets.
Joan hooks up with a famous actor at the bar, but her friends tease her about the fact that he will only give her his pager number. Joan manages to pry his home number from him, but panics when he doesn't immediately call her back, and makes the mistake of repeatedly calling his number to let her friends hear his answering machine message. Meanwhile, Toni begins dating a single father and grows surprisingly attached to his young daughter. Maya uses her friends as a cover so that she can spend time with her ""friend"" Stan. Lynn tries to avoid Vosco.
Dar sneaks into Xinca to rescue an extraordinary horse, despite a fortune-teller's warning that this will lead to Dar's own death.
While cleaning out the Heffernan freezer, Carrie comes across the top tier of her and Doug's wedding cake, and reflects back to the time when they got married. As she takes a trip down memory lane, Carrie remembers her uneasiness prior to their wedding day and her desperation in needing a sign from God to be sure about the marriage. The priest calms Carrie's insecurity by informing her that she and Doug actually met years before when they were kids. Carrie feels that that's a "sign" from above, but Doug later learns that it was Danny, his cousin, whom she met, not him, and is afraid to tell her the truth. Also, Arthur convinces Doug's parents to cover the cost of the wedding, and then proceeds to spend all their money to make the day extra special.
Even though his co-workers want to nominate him for the "Paramedic of the Year" award, a pensive Doc is disheartened as he considers his unfulfilled life. He later teams with Kim as they try to save a heart-attack victim while fending off a woman wielding a meat cleaver. In addition, Doc tries to minister to a chronic old drunk and a teenaged girl who attempts suicide in her bathtub. Meanwhile, Faith secretly undergoes a procedure to determine if the lump in her breast is cancerous, leaving an unsuspecting Bosco assigned to a nervous rookie cop; Kim reluctantly consults a lawyer about Jimmy's intention to claim custody of Joey.
Since Greg and Kim plan to go away to see Greg's folks for Thanksgiving, Jimmy wants to invite his parents over to the Warner house. But Christine doesn't want his father there as all the man does is criticize his son. Jimmy feels he can impress his pop now because he's got a great job and family. Jimmy gets his wish; after the Warners leave, Big Jimmy and Kitty arrive. And they've brought company -- Aunt Betty, Grammy and cousin Neil the ex-con. But Big Jimmy is still not impressed and keeps criticizing Jimmy since Greg foots the bill for him and he bailed out of college. Meanwhile, a blizzard forces Greg and Kim to return home, and Greg prepares to go to bed, unaware Jimmy let Grammy sleep in his room. When he finds her there, he screams so loud that he kills her. Greg tells Kim, who dials 911, then wakes up Jimmy and Christine to break the bad news. They assume that Grammy passed away in her sleep -- which Greg plays along with. After the ambulance takes her away, Jimmy tells the ot
Event: GREECE 800 B.C. Sydney is grabbed by mysterious men, who lock a necklace on her. The next morning, under the influence of Carson Inez, she declares an indefinite leave of absence and departs for Greece with Inez. Karen and Nigel are shocked, and Nigel soon ascertains that the amulet has mind-control powers. He travels to Greece, where he finds that Sydney is willingly helping Carson to locate the tomb of Athena. Despite his best efforts, Sydney remains under Carson's thrall. Nigel is captured and reluctantly helps the two women. He later escapes, and Carson and Sydney make a try for the statue. Sydney realizes something is amiss and during moments of clarity manage to inscribe the incantation that binds the necklace wearer. Sent to kill Nigel, she manages to get it to him and he frees her. They capture Carson and avoid her men by putting her under the necklace's control.
Renee visits Boone and shows him a crystal that can project the location of every Atavan on Earth. In an effort to retrieve the crystal, Sandoval brings Zo'or back to life as an Atavus so that she can battle her old nemesis Boone.
Dr. John Becker goes through his daily routine of being a doctor, stopping at his favorite diner, and other various situations, all the while hating life and everything around him.
Matt, Lucy, Simon and Ruthie are banished to the garage apartment after protesting Annie's decision to give the place to Mary, but then the roommates begin voting each member vies for sole ownership. Meanwhile, Eric and Annie are not seeing eye-to-eye on Mary's situation as she is now returning home and is wondering on what's next in her life. Robbie is nervous about meeting his new girlfriend's parents.
Jack and a mysterious woman goon a quest in an attempt to resolve their personal goals.
In this two part episode women are turning up…buried alive. Jordan teams up with a FBI Agent to try to solve this case. What Jordan does not know is that she matched the profile the killer likes.
It's the first Thanksgiving since Debra's parents divorced, and Debra is thrilled that both her parents have agreed to have dinner with the Barone family. However, she soon learns that her father is bringing a date. Everyone is horrified except Debra's mother, who thinks it's just great.
Larry can't believe that the Jewish man who is marrying Cheryl's sister is converting to Christianity. Richard Lewis accused Larry of stealing the outgoing message of his answering machine, and Larry accuses several passengers of stealing his airline tickets.
Sydney goes undercover in a mental institution to get information from Shepard, a man who has been unconsciously programmed to be a deadly assassin. Meanwhile, after Sydney becomes convinced that her father was responsible for the death of her mother 20 years earlier. Will discovers the true identity of the woman who claimed having an affair with Danny and Francie is relieved to learn that Charlie is not having an affair other woman. Marshall finds the computer worm planted in the SD-6 mainframe by the CIA.
Doggett catches up with Shannon McMahon, the woman who the EPA official picked up. She claims to be a super soldier and that the people she has killed were poisoning the water supply, and she wants Doggett to expose the truth.
Lois, in an attempt to get a break from the family, joins a book club that turns out to be a night off for frustrated housewives, but it all goes a little bit haywire. Meanwhile Francis tries to get to Alaska, learning something important about himself and about truck drivers. Hal, who tries to keep the boys out of troubles for the evening, is caught in an inner conflict about how to treat them.