A woman's car is run off the road and she is killed, but her baby miraculously survives the accident. Booth and Brennan go to the woman's hometown to try to find out who's responsible for running her car off the road. Bones, with help from Booth, takes care of the baby until the team finds out who killed the mother.
Serena's world descends into chaos when a former friend, the evil Georgina Sparks returns to town. Nate connects with the last person he expected, Vanessa. Blair hatches a plan to sabotage her biggest rival, Nelly Yuki. Meanwhile Serena goes out with Georgina, but things get so bad that Serena thinks someone spiked her non-alcoholic drink. Jenny develops a crush on a dog-walker, Asher Hornsby, who might be her ticket to permanent popularity.
Barney and Marshall have a discussion about "The Bro Code" because Barney has broken it and wants advice.
House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy's orders to give performance reviews, and fighting with Amber over who gets to spend more time with Wilson.
When delivery of another collectible leads to Penny's lashing out at Leonard, he decides it's time to give up his habit, much to his friends' protestation.
Robert fails a drug test but is determined to prove his innocence. Meanwhile, the Hammersley uncovers a smuggling operation by Samaruian rebels which is designed to destabilise the government.
Nathan and Haley throw a birthday party for Jamie. Deb hired a clown, and Haley is not happy with it since it's a creepy one. Lindsey returns to Tree Hill for Jamie's birthday, which gives Lucas hope that the relationship will be rekindled. When Dan arrives, Deb's mood swings fast and in the meantime Brooke and Peyton attend the party with baby Angie.
Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.
Bart joins the 4-H club and raises a calf to be a blue-ribbon-winning bull, but panics when he learns the bull will be slaughtered.
Attempts to legitimise the King's marriage and increase his power hit unmovable obstacles as Sir Thomas More and Bishop Fisher insist that only God can be head of the church. Imprisoned in the Tower of London they face likely execution unless they take the Oath of Allegiance. Meanwhile Henry's wandering eye continues to roam.
A terrorist cell infiltrates the NorBAC lab and forces the scientists to produce a deadly measles mutation to be used as chemical warfare.
Chris' attempt to be a "cool" kid lands him in hot water when he is caught with cigarettes and is suspended from school. Kicking him while he's down, Tonya blackmails him when she finds out before their parents do. Meanwhile, Rochelle decides to teach Julius a lesson.
In an attempt to solve Scotty's financial issues, Kevin offers to file domestic partnership papers with him. Meanwhile, Nora meets with an interior decorator in an attempt to try and make a fresh start and the Walkers' attend a fundraiser for cancer research.
Brian, afraid that he may have lost his last chance at love, searches for a former flame, Tracy. To his surprise, he discovers that he is the father to her son, Dylan. Tracy decides that Brian should raise the boy, and she drops him off at the Griffin's house. When Dylan runs rough-shot in the house, Brian's attitude towards parenting doesn't settle too well with Lois and Peter.
Zoey's Physics teacher decides to take the class on a field trip to go on a roller coaster, and all the students are ecstatic, except for Michael. He's got a big problem, but will the gang be able to help him out, and will Lisa stand by his side?
The demonic Shredder has transformed New York City into a nightmare version of Feudal Japan and the rest of the modern world is next! But the Turtles have a plan, and if it takes allying themselves with some of their former enemies to bring the fight to the Shredder, so be it... because if they fail, all life as they known it will cease to exist.
Stressed that her birthday parties never live up to her expectations, Peggy plans herself a disco-themed party on a mystery train, but after Luanne ruins the surprise, Peggy worries her parties will always end badly. However, a new mystery arises after a couple sneaks away for some private time in the train bathroom, and the partygoers must figure out who did it.
Stan hunts for an ex-KGB agent but can't find him--until he moves in next door. And Steve is building a rocket for a school science project, but can't get it to work--until he gets some help from his new next-door neighbor. Meanwhile, Roger and Klaus head off on a European vacation.
Arcadia is plagued with evil, life-draining demons called Thanatos and a vast lack of Purifiers to exterminate them all. While attending school, Angelique attracts the eye of a man who intends to turn the tides to the people's favor. What lies within her is the key to Arcadia's survival.
Nick Cheney was once a successful director, but he has now ended up mainly directing low-budget films. We meet him as he is directing The Scarlet Pimpernel at Magna Manor. A former convict, Jed Norris, has been hired as a security guard on the film set, and one night he finds the director dead, beheaded by the use of a guillotine.