Cassie's family and friends are too wrapped up in their own worlds to notice that she's not eating - but there is someone who cares.
The race for the Chief's position is on, and the attending physicians, Derek, Burke, Addison and Mark, compete for Richard's affections by trying to help out everywhere possible. The Denny Duquette Memorial Clinic is open for business, but only one single patient shows up. Izzie is disappointed in what she invested Denny's legacy in, and tries to steal patients from the emergency room. Callie and George get back from Las Vegas, announcing their marriage, much to everyone's disbelief. Izzie is not supportive of their marriage and tries to get George to realize the mistake he has made. Meanwhile, Meredith's Alzheimer's-stricken mother, Ellis Grey, experiences a change in her medical condition by becoming lucid for the day. She is disappointed in the mediocrity her daughter has fallen into and begins to despise Derek, blaming him for what happened to the Meredith that used to be "a force of nature". Ellis has to have heart surgery and, despite her wishes, Meredith schedules her upcoming surgery. Richard talks to Ellis and realizes that she is still in love with him, but loses her memory after their talk ends, before Meredith has the chance to tell her how she really feels.
An angel causes people to cheerfully go out to murder, and when the Winchesters investigate one of them falls under its sway.
Clark is once again exposed to red kryptonite, and his "other self" goes on a rampage of sorts on Valentine's Day, kissing the women he's most attracted to and expressing his uninhibited feelings for the various relationships around him.
In Memphis, Tennessee, a woman is brutally stabbed and left for dead in the street. When a witness comes forward with the license plate number of a van she saw driving from the scene, the homicide team must employ unique tactics to lure the suspect in. In Dallas, Texas, Detective Rick Duggan investigates the murder of an elderly man, shot inside his dental clinic. Investigators have little to work with until a woman comes into headquarters with information that seems too good to be true.
Michael celebrates Phyllis' wedding shower by bringing two adult performers into the office, a stripper and Ben Franklin. Meanwhile, Karen confronts Pam about her past history with Jim.
The notorious serial killer, Howard Epps, sets his prison cell on fire as part of a daring prison escape. Brennan is his target and her entire team is placed in danger.
Allison has unsettling visions about a father abusing his young son (Bryce Robinson), who in turn seeks comfort in a talking doll that may be delivering sinister messages to the child. Meanwhile, health issues rattle Joe as he takes on a looming project deadline.
The four remaining teams each get a dog; the geeks must get women's phone numbers at a dog park.
When Dana gets into premature labor, and Ryan isn't able to come and deliver the baby because he is delivering a celebrity's baby, Jim has to be the one to deliver Dana's baby.
The Panthers prepare for their first playoff game.Coach Taylor gets distracted as he has to come up with a solution to Smash's use of drugs. Tyra and Julie befriend while Riggins bonds with his alienated father.Buddy learns about Jason and Lyla's engagement.
Angie maintains her story that shes pregnant to keep George from missing Carmen. Meanwhile Vic introduces his young and beautiful but not too bright fiancé to the family.
To catch a predator shows us the investigations carried out using the hidden camera from Dateline NBC.
Ian gets more than he bargained for when a new person enters his life. Another death in the Maguire household causes Mimi to think the family may be cursed.
Lucy publishes photos of action-movie star Jack Dawson in the arms of her brother Leo; menacing visitors threaten Brent Barrow to reveal Lucy's source about the murder of Aundre G; Julia interrupts a photo shoot for Holt.
Veronica is hired to track down a one-night-stand, but the situation becomes more complicated when she turns out to be a hooker. Meanwhile, Keith continues his investigation in Dean O'Dell's death, and a visit by Madison Sinclair causes trouble for Veronica and Logan.
Sookie acts strangely. Luke attends his court case hearing. Lorelai is confronted about the character reference letter she wrote for Luke.
While House is forced to work full-time in the clinic and deal with a rape victim who insists on confiding with him, Cameron deals with a terminal cancer patient trying to take advantage of her state of mind.
Mike joins the Bowie BaySox team at Prince Georges Stadium in Maryland acting as a groundskeeper. Next he fixes boat moorings with a former Navy SEAL. He then joins Watson Water company dig deep through mud, rock, gravel, sand and water as they drill for heating and water in Tennessee. Also, Mike takes a dive into the mail bag.