The squad is joined by Eddie Gibson who's been transferred from nightwatch. McDowell and Gibson investigate the murder of a woman with MS, while the other detectives investigate the killing of a Rikers corrections officer.
Nick Fallin finds himself the advocate for a 12-year-old girl, Lesley, who needs to be adopted by foster parents immediately in order to receive a heart transplant. Laurie Solt, a social worker for Legal Services (LS), is having trouble placing her due to the many demands of caring for a child with congenital heart disease. Inspired by Lesley's strength after she learns her current foster parents are unable to adopt her, Nick takes the search on as a personal campaign to save Lesley's life. As hope of finding suitable foster care fades, Nick decides that the only way to save Lesley's life is to become her legal guardian. Nick's supervisor at LS, Alvin Masterson questions Nick's ability to care for Lesley. Eventually, the judge does grant Nick legal guardianship. Meanwhile, one of Burton Fallin's old friends, Harry Josephs is dying of cancer and tells Burton he is challenging the employment contract of Hopeson, Inc., which terminates employment if an employee is unable to work for 90 consecutive days. Hopeson Inc. is a long time client of Fallin & Assoc. and Burton helped finalize the original employment contracts. Burton struggles with the responsibility of fighting for his clients and opportunity to stand by his friend.
J.D. gets to see the hospital through the eyes of a patient when he's admitted for appendicitis. Elliot examines him and he tells everyone how cold and rough she is, which drives her crazy. J.D. doesn't want Turk to operate on him, which hurts Turk's feelings. Meanwhile, Dr. Cox is trying to show off to his mentor, Dr. Benson, the ex-chief of medicine, who is also a patient at the hospital. The only thing in his way is Dr. Kelso, who almost dismissed Dr. Benson prematurely.
After their idyllic wedding, Isabel and Jesse are stalked on their honeymoon by her alien lover Kivar who plots to take her back to their home planet. Learning of this, Max and Michael arrive intent on destroying the alien. Meanwhile, Liz and Maria discover that Philip has begun a secret investigation of Max, including the diappearance of Tess, and he's embroiling Liz's dad into the whole thing.
Section 13 sends its best Agent, Taggart McStone to stop Dr. Necrosis. Jade stows away and accompanies him on his mission, sending Jackie after them.
Breanna's mother comes to town for Thanksgiving. Flex at first disagrees, but he soon falls in love with her again. They make love and the next day Breanna catches them thinking that her parent's are coming back together again. Later they attend Breanna's football game and after that they started arguing, so Breanna has some second thoughts about this parents together thing.
Nikki is stunned by a revelation about her Aunt Rita when the entire family appears on a game show that exploits family secrets.
Joan hooks up with a famous actor at the bar, but her friends tease her about the fact that he will only give her his pager number. Joan manages to pry his home number from him, but panics when he doesn't immediately call her back, and makes the mistake of repeatedly calling his number to let her friends hear his answering machine message. Meanwhile, Toni begins dating a single father and grows surprisingly attached to his young daughter. Maya uses her friends as a cover so that she can spend time with her ""friend"" Stan. Lynn tries to avoid Vosco.
No man escapes the Manhunters.' An alien court sends the Manhunters to bring Green Lantern back for prosecution on the charge of genocide, and the League gets involved.
Ally and Glenn continue their flirtation, which leads to their conscious avoidance of each other, which does not go unnoticed by the others at Cage and Fish. She insists he’s too much of a “boy” for her, but continues to be attracted to him. He’s drawn to her because she’s a little older. Both use Jenny’s feelings as an excuse to not date as well. John takes off for parts unknown, which worries the ladies of the firm, especially Nelle. Richard takes it in stride, and takes over John’s abandoned hole off of the unisex. Raymond is sued by a former coworker for sexual harassment, and asks Jenny to represent him...
While cleaning out the Heffernan freezer, Carrie comes across the top tier of her and Doug's wedding cake, and reflects back to the time when they got married.
In this two part episode women are turning up…buried alive. Jordan teams up with a FBI Agent to try to solve this case. What Jordan does not know is that she matched the profile the killer likes.
Dar sneaks into Xinca to rescue an extraordinary horse, despite a fortune-teller's warning that this will lead to Dar's own death.
Jack and a mysterious woman goon a quest in an attempt to resolve their personal goals.
Even though his co-workers want to nominate him for the "Paramedic of the Year" award, a pensive Doc is disheartened as he considers his unfulfilled life. He later teams with Kim as they try to save a heart-attack victim while fending off a woman wielding a meat cleaver. In addition, Doc tries to minister to a chronic old drunk and a teenaged girl who attempts suicide in her bathtub. Meanwhile, Faith secretly undergoes a procedure to determine if the lump in her breast is cancerous, leaving an unsuspecting Bosco assigned to a nervous rookie cop; Kim reluctantly consults a lawyer about Jimmy's intention to claim custody of Joey.
Since Greg and Kim plan to go away to see Greg's folks for Thanksgiving, Jimmy wants to invite his parents over to the Warner house. But Christine doesn't want his father there as all the man does is criticize his son. Jimmy feels he can impress his pop now because he's got a great job and family. Jimmy gets his wish; after the Warners leave, Big Jimmy and Kitty arrive. And they've brought company -- Aunt Betty, Grammy and cousin Neil the ex-con. But Big Jimmy is still not impressed and keeps criticizing Jimmy since Greg foots the bill for him and he bailed out of college. Meanwhile, a blizzard forces Greg and Kim to return home, and Greg prepares to go to bed, unaware Jimmy let Grammy sleep in his room. When he finds her there, he screams so loud that he kills her. Greg tells Kim, who dials 911, then wakes up Jimmy and Christine to break the bad news. They assume that Grammy passed away in her sleep -- which Greg plays along with. After the ambulance takes her away, Jimmy tells the ot
Event: GREECE 800 B.C. Sydney is grabbed by mysterious men, who lock a necklace on her. The next morning, under the influence of Carson Inez, she declares an indefinite leave of absence and departs for Greece with Inez. Karen and Nigel are shocked, and Nigel soon ascertains that the amulet has mind-control powers. He travels to Greece, where he finds that Sydney is willingly helping Carson to locate the tomb of Athena. Despite his best efforts, Sydney remains under Carson's thrall. Nigel is captured and reluctantly helps the two women. He later escapes, and Carson and Sydney make a try for the statue. Sydney realizes something is amiss and during moments of clarity manage to inscribe the incantation that binds the necklace wearer. Sent to kill Nigel, she manages to get it to him and he frees her. They capture Carson and avoid her men by putting her under the necklace's control.