The squad is joined by Eddie Gibson who's been transferred from nightwatch. McDowell and Gibson investigate the murder of a woman with MS, while the other detectives investigate the killing of a Rikers corrections officer.
J.D. gets to see the hospital through the eyes of a patient. Elliot examines him while Dr. Cox is trying to show off to his mentor, Dr. Benson, the ex-chief of medicine.
After their idyllic wedding, Isabel and Jesse are stalked on their honeymoon by her alien lover Kivar who plots to take her back to their home planet. Learning of this, Max and Michael arrive intent on destroying the alien. Meanwhile, Liz and Maria discover that Philip has begun a secret investigation of Max, including the diappearance of Tess, and he's embroiling Liz's dad into the whole thing.
Blood pressures and spirits rise as an intern becomes the pawn in Frasier and Niles' battle over a wine cellar tour.
Nick Fallin finds himself the advocate for a 12-year-old girl, Lesley, who needs to be adopted by foster parents immediately in order to receive a heart transplant. Laurie Solt, a social worker for Legal Services (LS), is having trouble placing her due to the many demands of caring for a child with congenital heart disease. Inspired by Lesley's strength after she learns her current foster parents are unable to adopt her, Nick takes the search on as a personal campaign to save Lesley's life. As hope of finding suitable foster care fades, Nick decides that the only way to save Lesley's life is to become her legal guardian. Nick's supervisor at LS, Alvin Masterson questions Nick's ability to care for Lesley. Eventually, the judge does grant Nick legal guardianship. Meanwhile, one of Burton Fallin's old friends, Harry Josephs is dying of cancer and tells Burton he is challenging the employment contract of Hopeson, Inc., which terminates employment if an employee is unable to work for 90 consecutive days. Hopeson Inc. is a long time client of Fallin & Assoc. and Burton helped finalize the original employment contracts. Burton struggles with the responsibility of fighting for his clients and opportunity to stand by his friend.
An old man uses green meteor rock to reverse the aging process, then gain vengeance on the children of the jury that put him away decades earlier. Meanwhile, another woman at the same old folks' home has prophetic abilities and she sees the futures of both Clark and Lex.
Lorelai and Sookie have the first fight of their long friendship when Lorelai panics and decides their dream of opening an inn together will fail.
Kimberly and Janet realize they are in danger after it becomes clear that their two dates have kidnapped them. Despite the threat on his life, Senator Palmer sneaks out of his hotel to meet a reporter who has damaging information that could affect his campaign. Back at the office, Jack has Jamey, a member of his team, decrypt the key card.
Eric is upset when Donna writes a story in the school newspaper that sounds exactly like events that happened in their relationship; he decides to write his own story. Red and Kitty have dinner with Bob and his new girlfriend. Red doesn't like her because she's taught Bob how to stand up for himself. Kelso invests in a pinball machine but loses out when Fez persuades the owner to get rid of it and bring in Space Invaders instead.
Willow turns Amy the Rat into her old self; Jonathan, Warren and Andrew steal a diamond; and Spike discovers something unexpected about Buffy.
While cleaning out the Heffernan freezer, Carrie comes across the top tier of her and Doug's wedding cake, and reflects back to the time when they got married.
It's the first Thanksgiving since Debra's parents divorced, and Debra is thrilled that both her parents have agreed to have dinner with the Barone family. However, she soon learns that her father is bringing a date. Everyone is horrified except Debra's mother, who thinks it's just great.
Matt, Lucy, Simon and Ruthie are banished to the garage apartment after protesting Annie's decision to give the place to Mary, but then the roommates begin voting each member vies for sole ownership. Meanwhile, Eric and Annie are not seeing eye-to-eye on Mary's situation as she is now returning home and is wondering on what's next in her life. Robbie is nervous about meeting his new girlfriend's parents.
No man escapes the Manhunters.' An alien court sends the Manhunters to bring Green Lantern back for prosecution on the charge of genocide, and the League gets involved.
Ally and Glenn continue their flirtation, which leads to their conscious avoidance of each other, which does not go unnoticed by the others at Cage and Fish. She insists he’s too much of a “boy” for her, but continues to be attracted to him. He’s drawn to her because she’s a little older. Both use Jenny’s feelings as an excuse to not date as well. John takes off for parts unknown, which worries the ladies of the firm, especially Nelle. Richard takes it in stride, and takes over John’s abandoned hole off of the unisex. Raymond is sued by a former coworker for sexual harassment, and asks Jenny to represent him...
Brum comes to the rescue when Scruffy the dog swaps his bone for a businessman's mobile phone.