When Boober's favorite sweet water disappears from the well, his nose leads him and his friends to the Gorgs' Castle where the sweet water is.
Boober suspects Red could be in danger and sets out with his friends on a heroic adventure to save her.
A boy named Lee goes to the Ghostbusters for help when his brother, Alec, begins acting strangely and doing bad things. When the guys decide to investigate, Egon learns a Grundel is making Alec do bad things and if something is not done soon, he will mutate into one.
The girls try to help in a campaign to get Gil Kessler elected as local official. To his advantage, his chances of winning are boosted when reporters snap photos of Blanche entering his home one evening while his wife was away.
When Sandra meets Brenda's math teacher at the Jenkins' apt., they begin dating and he gets more serious than Sandra. Then, Sandra comes by the Jenkins' with her new rich date, while Mitchell is visiting. To get Sandra back, he spends all his money trying to wine and dine her. One night at the Piano Bar he announces that he is going to begin working as a computer executive, thereby making more money. Mary talks to Sandra and says that Mitchell loves being a teacher and is only giving it up for Sandra and to make more money. He and Sandra talk and the show closes with Sandra announcing their engagement.
The Nephews, Webby, and Doofus attempt to earn a Junior Woodchuck badge in sailing while a sea monster is preying on Scrooge's shipping fleet.
After Angela and Richard meet the mysterious Carlton Travis, Angela conspires with Carlton to destroy Richard. Richard realizes that although Carlton is a man who won't listen to reason, he will listen to Angela. With all the trimmings Hollywood offers, Emma works on her screenplay. Melissa takes Dan to Australia to visit Cole and her son. With Frank Starr's assistance, Dina's nurse works on her patient to discredit Lance. Angela and Travis discover that they have a history.
Catherine has a nearly fatal confrontation with an ex-tunnel dweller, named Mitch Denton.
The return of a kingpin's financial wizard son sets off speculations in the Miami underworld.
Subway workmen accidentally open a door that unleashes all of the evil from hell and it begins to spread across New York, primarily through the subway tunnels. This time, the Ghostbusters may not come back alive!
Punky and Cherie enlist the help of the other tenants to help keep Maude Firestein from having to move to a nursing home. Maude is a favorite neighbor among the tenants, and the only tenant who doesn't like the effort to keep Maude from moving is chronic complainer Pete "The Crank" Frank. With a lot support from the neighbors, it turns out that Maude doesn't have to move.
Jane enters a garden contest. Astro crushes Jane's plant and the plant passes away. George buys Jane a new plant at 'Far Out Flowers', a rare import 'A Martian Creeper'. It turns out to be a very rare breed ...
Clayton's heart problem sees him ending up in the hospital. Casey Denault becomes fed up with his relationship with Marilee Stone. Sue Ellen comes to a decision about taking April on as a partner. J.R. investigates Wilson Cryder's wife. Bobby ends up receiving a surprise from Pam.
Danny's tryout as a cable boxing announcer isn't a knockout; the guys try to save the baby from being knocked out by a cold.
Punky tells Henry that she is afraid of being in any vehicle driven by her friend Joey Deaton's father Mike Deaton, because Mike has a drinking problem, but Joey and Henry are reluctant to believe Punky, even though she's telling the truth. When Henry and Joey see for themselves what Punky saw, they apologize for not believing Punky, and Mike decides to get help for his drinking problem.
Rudy visits Hillman and becomes enchanted by Whitley, who tries to make her into the perfect little lady.