When Coulson and his team are attacked by Lorelei - a deadly seductress who escaped from Asgard - Thor’s Lady Sif, her longtime nemesis, steps in to try to save them.
When Uncle Grandpa wakes up on the wrong side of the bed, he changes into a grumpy grump and it's up to the rest of the gang to reverse his bad day.
Lt. Severide hits the top of the list as Det. Lindsay starts calling in suspects with the clearest motives to make the guy who kidnapped Katie disappear. Meanwhile, Jones is still having trouble fitting in as word of her disruptions reach the fire department’s headquarters. Elsewhere, Herrmann celebrates his twentieth anniversary with his wife, but no one supports his idea on the gift he intends to give.
Jo decides to run for student body president; Lacey wants to know what Danny is hiding.
Raylan partners with a maverick DEA agent whose bad behavior feels uncomfortably familiar, while Boyd makes a hard choice to protect Ava.
Jordan sends everyone off to Liverpool to take Valleywood nights on tour as Nicole returns to the house to announces her new role as the photographer. The big night suddenly spirals into chaos as Jenna and Nicole get their boobs out during Lateysha's performance causing her to rage against them, which leads to a huge fight. As Lateysha packs her belongings and leaves, Jenna's fury turns to Natalee, and Carley ends up in hospital after a fall. Shocked at how the night has ended, Jordan considers ending Valleywood tours.
Adam tries to impress Murray with his ice hockey skills, while Murray tries to pretend he likes Adam's movies; Beverly hounds Erica about her S.A.T.s.
Daniel speaks to Congress and has lunch with a homeless man; a child forced to enter the workforce gets a Web redemption.
Things take a dark turn as the artists play the part of mad scientist and create human guinea pig makeups inspired by bizarre medical devices.
Hanna comforts Jim after Amanda's death.
Candace tries to blackmail Jim and David during their campaign event; Wyatt is arrested.
A woman fears that the man stalking her may be a serial killer.
Travis starts an open mic night at Coffee Bucks, but things go awry when Andy tries to do stand-up comedy. Tom's daughter Haylee comes to visit, and Grayson and Jules decide to play along when they discover that Tom's been lying to Haylee in order to make himself sound cool.
Zosia suspects Guy doesn't have his patients' best interests at heart.
The glee club -- and two special guests -- travels to Los Angeles to compete in nationals.
Mel and Henry encourage each other to pursue women in their building; Joyce panics during her first post-separation date and crashes her daughter's date at a carnival.
When a promising, bright college student unexpectedly joins a cult, her parents desperately try to get her out and turn to Edwards and Associates for their expertise. Later, Claire uncovers Ross’ deceit with Clark and feels compelled to reveal the truth. However, when she sees how happy Clark is, she faces a crossroads.
The cast is finally fed up with Kayla and confronts her about her manipulation and lies, Ryan reevaluates his feelings for her, and Chris S. tries to get in between Jacy and John J