After reluctantly going to Irina's, XIII and Irina are captured by a rogue team, and after escaping they are hunted by the commandos. Meanwhile Jones and Amos are becoming suspicious of CIA Director Frank Giordino.
Chuck and Sarah’s wedding prep includes one final detail: ensuring that the mother-of-the-groom makes it to the ceremony alive. Meanwhile, Morgan’s responsibilities as Best Man include his most dangerous mission yet, as he faces Vivian Volkoff. Elsewhere, Ellie tends to the last details of the rehearsal dinner and seeks help from an unlikely source.
XIII and Jones travel to Chicago in search of an agent who has one of the watches.
With the invaluable information that was shared by Agent Jenna Kaye, Five-0 is closer than ever to capturing Wo Fat. Their mission takes an abrupt turn, however, when Danny is exposed to a lethal neurological agent that presents an even greater threat: bio-terrorism on the island.
After losing a bet with Wilson over a boxing match, House is convinced that his fighter has an underlying medical condition that cost him the fight. While he tries to prove it, he leaves his team alone to help a bomb scientist who suffered a seizure. Meanwhile, House may be experimenting with a new drug to help his leg pain.
This trip Guy's rolling coast to coast for flavor. In Astoria, New York, a dive bar cranking out slow roasted lamb ribs with fresh tzatziki. In Geyserville, California, a third-generation Italian restaurant serving up the family meatball recipe in a slider. And in Indianapolis, a catering kitchen turned restaurant where something called tomato bon bons have become a local favorite.
When Ted is faced with an important decision that might affect his future with Zoey, the gang expresses their true feelings about her.
Goofy goes on a quest for a magical elixir to cure Willie The Giant's tummy ache.
Homer opens his own hair salon after discovering he is a talented stylist; Milhouse professes his love for Lisa.
Paul begins to suspect that Susan is responsible for his rapidly declining health; Lynette and Tom butt heads over where to go on their family vacation, as well as which one of them will set it up; Gaby shows Juanita a horror movie and has to pay the price when her daughter becomes too scared to sleep in her own bed; and Bree runs into some trust issues when she goes out on a date with a detective.
The invasion by King Charles of France and Della Rovere proceeds with victory seemingly inevitable as the French sack the city of Lucca and the Italian powers flee to their banner, with Lucrezia's husband Giovanni Sforza poised to join them in the name of Milan; inventor Leonardo Da Vinci (guest star John Lynch) shows his drawings and blueprints for war machinery to the invaders.
Stewie and Brian go back in time to stop Bertram from killing Leonardo da Vinci in order to erase Stewie from the universe.
Bob and his family are forced to spend the weekend at Mort the Mortician's while the restaurant is being de-molded. Linda and Bob double date with Mort and a female mortician he meets online while Tina babysits Gene and Louise in Mort’s crematorium.
Stan and Francine fight over how to redecorate the house. It goes so far that they split the house down the middle and try to live without each other. Meanwhile, Principal Lewis discovers a talent of Barry.
In the season finale, Horatio must capture an escapee again when their transport plane crashes. And the team was shocked to discover that the fugitive has planned more than that.
Mitch questions the validity of the police investigation while Richmond has to deal with a negative ad. It's discovered that Rosie was at Bennett's apartment the night she died.
Goren and Eames return to the Major Case Squad after a year-long absence and must determine if a banker was murdered or committed suicide. They discover the bank's only client is the Catholic Church and dig into a scandal and cover-up linked to the murder.
Margaret Bradley had Multiple Sclerosis and was living with her daughter, Rhonda, a nurse. A part-time aide helped Margaret while Rhonda was at work. In 2002, Margaret suddenly fell ill and died the next evening of unusual and dangerously low blood sugar levels. Rhonda, who knew her mother didn't have diabetes, looks into her mother's untimely end and wonders if her mother's death was really murder. Her search for answers would eventually lead authorities to open a criminal investigation.
Toni's investigation of a post-Katrina casualty gets more confusing at every turn; a routine closing at the bar for LaDonna becomes a disaster; Janette is forced to make a quick trip back to New Orleans to tend to a housing crisis; Nelson ups the ante in his business deal with Robinette; Antoine practices with his new band; Sonny turns to another musician for help when his home is vandalized.