Ambushed by angry hunters, Sam and Dean are shot and killed and sent to Heaven. Castiel warns Dean that Zachariah is looking for them in Heaven so they need to lay low while searching for an angel named Joshua who can help them since he talks directly to God. While searching for Joshua, the brothers run into some old friends and family members.
When Alex's younger brother, Aaron, shows up at Seattle Grace-Mercy West with a hernia, it's up to Alex to get Bailey's approval for his pro bono surgery. Matters are further complicated when Aaron discloses that his family has not heard from Alex since he arrived in Seattle, and parts of Alex's past long kept secret are revealed to his friends and fellow doctors.
Patrick and the CBI team investigate the murder of a tutor, and find a mysterious little red box near the body, starting a chain of events that turns the murder into the search for a priceless ring stolen from the British Museum. Meanwhile, Lisbon is worried when a new boss, Madeleine Hightower, takes command of the CBI, as well as mysteriously learning about Rigsby and Van Pelt's relationship.
Demetri, Janis, Simon and Vogel travel to Somalia in search of clues to a mysterious tower and encounter a dangerous man who saw his fellow villagers black-out in Bryce tells Nicole that he has cancer and Olivia attempts to get daughter Charlie to tell her what she saw in her flashforward.
Anna brings a surprising guest along when she pays a visit to Damon. Elena and Stefan go on an awkward double date with Caroline and Matt, but Stefan and Matt find they have some common ground. Jenna reunites with her old friend Kelly, and Jeremys relationship with Anna takes an unexpected direction.
Walter explains to Olivia how Peter came from the alternate universe, and how he was willing to risk everything to save his son.
When famed neurosurgeon Dr. Ginsberg and her team pay a visit to St. Ambrose to save the life of Kayla, Addison is shocked to see Amelia Shepherd - Derek's younger sister on the team. But Amelia's presence causes strife between Addison, Sam and Pete when she claims she can save Kayla's life after Dr. Ginsberg declares nothing can be done. Meanwhile Charlotte seeks from Cooper's with a sex education seminar for the elderly that only leads to more tension between the two, as they try to figure out how to work together.
When a subway train is thrown off the track by 60,000 gallons of flood water, a partially skeletonized body emerges out of the overflow. While Dr. Sweets, a passenger on the derailed train, copes with post traumatic stress, the rest of the team and intern Daisy Wick get to work on identifying the victim as Martin Aragon, a professional ghost writer caught up in a deadly love triangle. Meanwhile, Brennan releases her second book to great success, but has to accommodate a nosy reporter, and Sweets' near-death experience leads him to make a drastic decision.
The adventurers meet Roland a young trainer who falls victim to Team Rocket's latest ploy. They also meet Bertha, one of the Elite Four.
A princess asks Dawn to trade places for a day, so that the princess may compete in a Pokemon contest.
Join Maeve O'Meara and Melbourne chef Guy Grossi in an Australian-wide celebration of traditional Italian food and culture.
Two children dress up as superheroes and create chaos wherever they go.
A medical drama about a team of expert trauma surgeons, who shine brightest when working under pressure against the clock to save critically injured patients.
A rape and murder helps Benson and Stabler crack a case involving a serial rapist and killer from the 1970s. However, one copycat crime remains open when investigation reveals that the crime was committed by a woman.
Josh heads into New Jersey's Wharton State Forest and teams up with Kris Williams from Ghost Hunters to search for the legendary Jersey Devil. In the next segment, he and his team go to China's Hubei provence in search of a Bigfoot-like creature called the Yeren.
Tensions are at an all-time high with Jake's older brother Christian back in town and the Doyles are on a case involving Walter's soon-to-be brother-in-law.
Chance travels to a remote Alaskan island to find a missing doctor and expose an industrial giant's involvement in the death of a mining foreman.
Mike's dream comes to fruition when Frankie's boss, Mr. Ehlert, offers him two tickets to the Final Four. Unfortunately, Frankie's uncle dies and the funeral is set for the same day, leaving the two in a battle and Frankie making Mike chose what life event is more important to him. Meanwhile, Sue gets Brick out of going to a birthday party by impersonating Frankie over the phone, but the plan hits a bump when Frankie needs to call and tell them that Brick cannot attend because of the funeral.
It could not be more perfect that Phil's birthday and the release date of a hot new product coincide, and he wants nothing so much as to be one of the first people to get one this is Claire's mission. Meanwhile, before coming to Phil's party, Mitchell is preoccupied with a new found desire to toughen up, Cameron gets himself involved in a neighbor's marital problems, and it's Jay against Gloria and Manny in chess.