Castiel helps Sam and Dean hunt down Cupid on Valentine's Day after townspeople start to kill each other for love. However, after Cupid tells them he's innocent, they discover Famine, one of the Four Horsemen of the Apocalypse, has arrived in town.
Due to the aftermaths of a terrible mistake, Jeff attempts to reconcile his friendship with Britta. Shirley and Annie want to pull a prank on Seor Ben Chang.
Cook is up on a charge of GBH. Despite multiple witnesses, he insists on pleading not guilty, to the frustration of his brief, Duncan. Hes granted bail but given an electronic tagging order and curfew to the house of his Mum. Mum is Ruth Byatt, a famous contemporary artist. Returning for the first time in a while, Cook is reunited with his younger half-brother Paddy, who idolizes him.
Stefan helps Elena and Bonnie out of a dangerous situation. Jeremy asks Anna to a party in the woods, unaware that she has her own reasons for wanting to meet him there. When Stefan, Damon, and Elena work with Bonnie and Grams to open the tomb, everyone is shocked by what they discover.
When a member of Cho's former gang, the Avon Park Playboys, is found murdered, Patrick Jane insists on helping Cho with his off-the-books investigation.
When Michael's old acquaintance Larry shows up unannounced, it is up to Michael to clean up his mess. Meanwhile, Michael's brother Nate shows up with his new wife Ruth.
Sabre's CEO wants the Scranton branch to have one manager, and Michael voluntarily steps down and lets Jim become the boss when he finds out that salespeople make more money. However, he soon comes to regret the decision.
Caitlin and newly single Jen both want to date the same guy, the new mall handyman, and when neither of them will back down Nikki suggests they make it a friendly competition.
A Sadie Hawkins dance comes to the mall where the girls ask the guys out. While Jude and Wyatt struggle to get chosen, Caitlin and Jen try to overcome the pressure of asking the guys. Nikki becomes friends with a new Khaki Barn employee Jean, but spends so much time with her, she forgets to ask Jonesy to the dance, and Caitlin needs to find a way out of date with Wayne after he mistakenly thinks she asked him out.
Wyatt, Caitlin, Jen, and Jude are loveless at the time so they get mad when they see Jonesy and Nikki flirting with each other right in front of them. Nikki suggested sarcastically to join a speed dating session, and Jonesy decided he wanted to host it because he got kicked from his last job, and needed money. So, Nikki and Jonesy start a speed dating service for Jen, Caitlin, Jude and Wyatt to help find their special someones. Jen received a new method of being mean and unattainable for getting guys from Jonesy while Nicki seconded Caitlin's idea to be nice and ...
Belle entertains Des, a young man who loves to be covered in messy foodstuffs, not the most erotic subject for her next chapter, so she turns to Duncan for the real thing. Bambi tries in vain to reject an ardent Byron, who buys her a bicycle and proposes to her whilst Ben breaks things off with Jackie.
Sam convinces Violet to help plan Maya's wedding when Naomi refuses to take part, tensions between Addison and Sam rise even as they work together to treat a suicidal patient, and Cooper and Pete treat a teenage girl with a mysterious bite mark on her neck.
Shin Young proposes to Sang Woo that they both get back together. Sang Mi rents out her son's apartment to none other than Sang Woo.
Liz schedules a root canal to avoid feeling lonely on Valentine's Day; Jack woos an attractive and successful TV host; Jenna's stalker loses interest.
When a promising female tennis star loses her scholarship, Susan gives Beth and Dylan the challenging pro-bono case -- which questions the player's personal identity -- while Liam and Malcolm are pitted against each other.
The designers must create a look to be worn by Heidi Klum on the cover of Marie Claire.
It's Valentine's Day, and the doctors must treat dozens of injured people after the roof collapses at a popular romantic restaurant; Derek tries to manage his busy schedule as Chief of Surgery; Meredith wrestles with her new duties as the Chief's wife; and Mark and Callie team up to convince Sloan to do the right thing for her baby.
Archer must rescue Lana from the clutches of Skorpio, the infamous arms dealer. Meanwhile, Cyril fears not only for his girlfriend's life, but her succumbing to the seductive nature of Archer's heroics.