Lily and Rufus decide to move up their wedding to the next day, but will someone or something come between them before they become man and wife? Chuck discovers a secret that Carter has been keeping from Serena. Dan and Vanessa are pulled into one of Georgina's schemes. Blair is suspect of Bree and shares her concerns with Nate.
A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present information on the Dibala case.
Haley Bethany Joy Galeotti is thrust into the spotlight and storm of Nathans James Lafferty growing scandal. Against her better judgement, Brooke Sophia Bush allows Julian Austin Nichols to continue working with Alex Jana Kramer Entourage. Millicent Lisa Goldstein gets a new job, which may cause trouble for Mouth Lee Norris. Meanwhile, Clay Robert Buckley and Quinn Shantel VanSanten grow closer.
When an Arctic explorer is killed during a polar expedition, the mysterious circumstances of his death take Castle and Beckett from the penthouses of Park Avenue to the halls of the CIA. But Castle's delight at the case's many twists and turns soon turns to frustration as he realizes that their elusive killer might just be fooling them all.
A chance encounter reunites Gaby with her sexy ex-lover and gardener, John Rowland Bree contemplates a weekend getaway with Karl Lynette and Tom break the news to their kids that she's pregnant again and Susan is convinced Angie's son is responsible for her daughter's attack.
Hank attends a university mixer and consoles his jilted assistant; Charlie celebrates his first talent signing.
An -year old in need of a double-lung transplant, struggles to survive as the team runs into an obstacle that may prevent her from being eligible for the procedure.
Dexter is hampered by his neighborhood's increased vigilance due to vandalism, his temporary inability to drive himself anywhere, and his admiration for the killing technique of the artful Trinity Killer.
Chevy Chase and Dan Aykroyd move to Quahog. Brian and Stewie find out about their secret agency. They are told that there are Russian Sleeper Cells all over US. They go talk to Mayor West, and find out he is one of the sleeper cells. They follow Mayor West to Russia where they disable a nuke aimed at the US.
The men and boys in Springfield become obsessed with Ultimate Punch Kick and Choke Championships, a violent sport where fighters inflict severe pain on each other. When Marge and her friends stage a protest against the sport, the show's promoter embraces the controversy and challenges Marge to a match, promising to shut down the competition if she wins. She begins to train with rhythmic gymnastics, but her family step in and get her professional martial arts help to give her a real chance at winning.
Kitty, Robert and Nora struggle to accept Kitty's cancer and to come to an agreement on the best possible treatment, but as they prepare to share the news with the entire family, a surprise visitor from afar makes the burden a bit easier to bear.
The lives of the kids at Degrassi Community School dealing with the serious and sometimes taboo issues that plague teenagers.
Jane and Spinner have been through so much together. They're best friends. Jane's just come out of a difficult year at home, so hanging out with Spinner is safe and... easy. That's not a bad thing, right?
Cleveland gets Lester's son Ernie to become Cleveland Jr's friend, but later accidentally gets Ernie taken away from Lester by Child Services.
Larry makes an enemy of Christian Slater at Ted and Mary's anniversary party, but gets his payback while at a restaurant with an old flame. Meanwhile, Larry's doctor gives him his personal number and soon regrets it.
Emma continues her attempts to marry off Harriet and Mr Elton, vicar of Highbury. Although uninterested in marriage herself, she is intrigued by the mysterious and elusive Frank Churchill, who she hopes to meet for the first time at a village Christmas party. Frank does not arrive, and instead Emma becomes the subject of unwanted and embarrassing attention from Mr Elton. A few weeks later, village gossip and speculation focuses on the arrival of young Jane Fairfax and a large piano she has been sent by a mystery admirer. Emma refuses to believe that Mr Knightley could be the secret admirer. He couldn't be, could he?
As Stacey helps Grayson represent a lingerie model who was fired after having surgery for breast cancer, Jane is assigned to represent a young baseball star.
Dr Martin Ellingham is called to Louisa's new home after she has a dizzy spell while shifting furniture. Martin urges her to slow down, but is shocked to learn that Louisa has applied to be her school's headteacher again.