After looking at hundreds of homes John and Cecile found the "perfect house" and were on the path to early retirement when life took them in a different direction. John and Cecile's once "perfect" home is no longer as they are now in a position where they need to make some major changes. Will Hilary be able to sway Cecile and show her the house has the potential to carry them through this transition period or can David convince John the time has come to explore other options and move.
Unexpected visitors greet H.R.G.; Samuel's plan starts to come to fruition; struggling to accept the truth, Peter takes extreme measures to get what he wants; Claire's journey leads her to an unexpected destination.
Nathan and Haley’s careers bring about a tough decision for the family, and Julian divulges a secret to Alex that leads to a confrontation with Brooke. Meanwhile, Clay tries to resuscitate his career as an agent, and Jamie learns the truth about Skills’ new job. And a fresh-from-jail Millie finds an unlikely supporter in Victoria.
The Pawn Stars want to buy an airplane propeller that may be historically tied to Charles Lindbergh - can they find an expert or documentation to confirm the link or will this deal crash and burn? Then when a man brings in a 1750s Flintlock Musketoon, Rick has doubts about its authenticity. And later a young man brings the Old Man a key chain that he believes belonged to Willie Nelson - the only question is - which one.
Lightman, Foster and Reynolds travel to Las Vegas to help locate a missing finalist in the World Series of Poker. Lightman uses his skills to read the other competitors' faces to figure out which one knows about the disappearance. Meanwhile, Loker and Torres analyze Loker's new relationship, and as a result, get closer to each other.
When an old friend and former patient of Wilson’s exhibits paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient’s symptoms are attributed to new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to diagnose the patient more optimistic results, but when things take a turn for the worse, Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.
It wouldn’t be Thanksgiving on the Upper East Side if there wasn’t a serving or two of some major drama for the holiday. Blair suspects her mom has been keeping a big secret from her, but it turns out to be something else entirely. Vanessa is supposed to spend Thanksgiving with her parents, but has a fight with her mom and shows up on Dan’s doorstep. Rufus learns that Lily has been lying to him about her mother, Cece. Chuck tells Nate that he has some potentially damaging information about one of their friends. Jenny learns that Eric was behind her very public embarrassment at Cotillion and can’t pass up a chance to get even. Serena is put in a very awkward position when her mother invites Trip and Maureen to join them for Thanksgiving dinner.
When Brian accidentally kills another dog, he is surprised to see that no one cares, so he tries to convince everyone that the life of a dog should have the same value as a human one. Meanwhile, Lois hires a maid who doesn’t listen to Peter
Hank takes Charlie out on the town to drown his sorrows after Sue Collini fires him for causing client Rick Springfield to leave the agency. Meanwhile, Karen, still miffed by Hank's dalliance with Felicia, organizes a girls' night out with Becca and Marcy.
A husband catches his wife having an affair with a mysterious lover, but just after she ends the affair she winds up dead and police must figure out if it is a tragic accident or murder.
Lisa befriends three teenaged Wiccans after getting lost in the woods during a game of hide-and-seek, and must clear her new friends' names when they are accused of cursing the townspeople with their supposed witchcraft. Meanwhile, Homer befriends Cletus after learning that he and his friends make their own moonshine.
Cleveland and Donna are excited to have the house to themselves when Cleveland Jr. and Roberta go on a school trip to Washington, D.C., but a disgruntled Rallo will do whatever it takes to keep Cleveland and Donna apart. Meanwhile Roberta's partying gets out of control and Cleveland Jr. comes to her rescue.
A look at marine invertebrates, including Humboldt squid, starfish and giant octopuses.
Rebecca has a secret that could make or break her relationship with Justin; Holly's financial situation worsens; Sarah becomes jealous of Nora's new romance.
Jean Grey has been abducted, but as the X-Men begin the search a new problem arises. Magneto has forced the hand of Senator Kelly into launching a Sentinel attack on Genosha so that he can strike back and begin the war! Meanwhile in the future, Mastermold has captured Xavier and is forcing him to reveal the locations of mutants all over the world!
The Inner Circle manage to draw the Phoenix out of Jean Grey but it proves to be more powerful than anyone could have imagined. Now Cyclops, Emma Frost and the rest of the X-Men must find a way to stop it before it destroys the world! Plus, the future X-Men begin their assault on Mastermold and the Sentinels!
Sentinels begin their attack on Genosha causing dissension in the ranks when Scarlet Witch makes an important decision about which side she's on. Plus, the Inner Circle's true intentions with the Phoenix are revealed causing Emma Frost to question her loyalty. Meanwhile in the future, the future X-Men form their plan to take down Mastermold.
Upset that Hayley no longer wants his advice, Stan decides to prove that she is missing out on his sage counseling. After meeting a stripper on an important CIA mission, Stan takes it upon himself to improve her life and show Hayley that his advice works. But when he opens a new business, hoping to prove Hayley wrong, he finds himself dancing for cash to cover up his failures.