Much to Clark's surprise, Martha Kent returns to Smallville with her new boyfriend, Perry White in tow. Lois and Perry realize they are both working on the same story about the Red Queen, and decide to team up, which ultimately puts them in serious danger. Chloe helps Clark search for the Book of Rao, which they believe contains information on how to stop Zod and his army.
Alex discovers her friend Stevie is leading a wizard revolution. To the dismay of Justin and Harper, she decides to help Stevie with her quest to make sure no wizard ever has to give up their powers again.
Catering an orgy proves to be the wrong place for Ron to deal with his recent breakup. Roman seizes the opportunity to help the host create the ideal orgy atmosphere.
Henry was 18 years old when he was killed, with a gunshot wound in his chest. In life he was a decent boy from a wealthy, loving family, whose parents believed that he should earn his own living and not rely on their handouts. He masterminded his own kidnapping with a friend of his, and seems relieved to be able to explain to his mother, via Melinda, that he's felt guilt and remorse ever since.
Nanite activity is increasing around the world. Rex decides to go to one area for Spring Break. He befriends a lonely young woman with a secret agenda.
The Destiny has jumped into hyperspace and is now traveling through an inter-galactic void. They've also been unable to locate Eli, Chloe and Scott who have been left behind. Dr. Rush has calculated that based on their current energy consumption, the Destiny has insufficient fuel to reach the next galaxy and they are doomed to die. The engines suddenly fail however and they arrange for an expert, Amanda Perry, to come on board via the communication stones and help them out. Perry and Rush have known each other for many years but as a quadriplegic, is experiencing what life has to offer. On Earth, Camile Wray's consciousness has been transferred to Perry's body and is wheelchair bound.
Violence at Miami's Calle Cubana celebration ups the ER staff's workload. A young teenager left at the hospital, near death, grabs Dr. Zambrano's attention.
Leslie hosts a late-night shift for a local telethon, and lands former Indiana Pacer Detlef Schrempf as a celebrity guest. Meanwhile, Mark has big plans for his relationship with Ann.
Crowley tells Bobby he will give him the location of Death, the fourth horseman, in exchange for his soul. Knowing Sam and Dean need that fourth ring to stop the Apocalypse, Bobby reluctantly agrees. Sam and Dean confront Pestilence, but he unleashes a deadly virus upon them, so Castiel must intervene on their behalf. Dean has a meeting with Death to discuss Lucifer, and an unholy alliance is formed at a very high price for Dean.
A kidnap drama on the ocean and relationship tremors below decks rock Hammersley as she sails the Coral Sea.
Sensing that he is in danger, a hero makes a bold move to save himself by fooling the entire tribe. Meanwhile, a vicious power struggle emerges in one alliance and two of the strongest villains find themselves pitted against one another.
In Noyo County, Washington, Peter stumbles across a grisly murder with ties to Newton and First Wave. He is forced to team up with a suspicious sheriff to get to the heart of the case. Meanwhile, Walter has trouble functioning without Peter, and worries he will be sent back to the mental institute.
Patrick Jane and the CBI team investigate the death of a mathematical genius by a gun-wielding clown.
Isobel returns to town and stuns Alaric with her attitude and her demands that he arrange a meeting with Elena. When mother and daughter finally meet, Isobel refuses to answer most of Elena’s questions, but reveals that she will stop at nothing to find the mysterious invention Johnathan Gilbert has been searching for. Isobel’s dangerous actions lead Stefan, Damon and Bonnie to step in and help Elena deal with the situation.
The first prize of priority registration engulfs Greendale Community College in a Spring Fling paintball war.
Michael suspects Donna is cheating on him and puts P.I. Dwight Schrute on the case. Meanwhile, Andy is frustrated when no one takes his customer's complaint seriously.
Naomi begs Fife to use his still experimental treatment to help William's advanced ALS. Violet and Amelia treat a woman with a brain tumor, while Sheldon decides to vie for Charlotte's affections.
Bailey preps the team with mandatory sensitivity training prior to admitting a 700-pound patient with compounded medical issues, and the case proves to be challenging in every sense of the word. Meanwhile Derek has to come face to face with a former patient's husband in a wrongful death deposition, and spending time with a heart patient's daughter opens up some old wounds for Cristina.
Bummer is having a breakdown, so the groms teach him to be chill and relaxed. But they do too good of a job and Bummer's mellowness gets him fired. Lo gets a lesson from her tough-as-nails Daddy on how to deal with her daycare kids. Meanwhile, Johnny finally scores a date with Emma, but it doesn't go the way he planned.
A cabin burns down in the woods revealing two bodies, one of a modern-day witch and one from the days of the Salem Witch Trials leading Booth and Brennan into the world of Wicca to find a killer. Meanwhile, when Hodgins' reckless driving gets him and Angela arrested and thrown in jail, Sweets and intern Clark Edison step into unfamiliar territory to help out the team