It may be sunny in Tucson, Arizona, but there's stormy weather at the Goldberg house. Parents Adam and Shelby have their hands full with their three young children. Although the kids act tough, in other ways they refuse to grow up. Jacob, 6, still sucks his thumb and will not let go of his "blankie," while little sister Jayden, 3, clings to her binkie and throws temper tantrums at the mere suggestion she give it up. Jacob has violent outbursts and, together with his twin, Joshua, plots attacks against their sister and mother. Neither parent knows how to control the kids or give them consequences for their actions, and Dad finds it hard to control his temper.
Macy Gray thinks she can run for President while Janeane Garofalo, Tori Spelling and Dean McDermott find Dr. Goode in a pre-nuptial bliss; Myron receives a timely gift from a car wash owner.
When her boyfriend Derwin Davis is chosen as the new third-string wide receiver for the San Diego Sabers, Melanie Barnett decides to attend a local college so she can be with him. While Derwin worries about the plays on the field, Melanie adjusts to her new lifestyle. She gets a play-by-play account of the lives and relationships among NFL wives, girlfriends and mom/managers who use their best game to help their men stay on the field and on their arm.
While test driving a car, Chris accidentally hits Greg. Greg ends up in a hospital for a broken leg. Since Greg's parents are out of town, Rochelle drops her vacation plans to take care of him, which leaves Julius to entertain the kids at the shore where it usually rains each day.
Failed actor Henry Pollard returns to work at Party Down catering. He meets his fellow employees, led by his old coworker Ron, a clean-living team leader with big dreams.
Magically transported to 19th century London, Batman aids Etrigan the Demon and Sherlock Holmes in battling Gentleman Jim Craddock, the future Gentleman Ghost.
In an attempt to force the release of the crime lord Ziro the Hutt from prison, bounty hunters seize control of the Senate Building and hold members of the Senate hostage. Cad Bane, the leader of the operation, with the help of bounty hunter Aurra Sing, issues his demands to Chancellor Palpatine who has no choice but to meet his request. Unbeknownst to the hunters, Jedi Knight Anakin Skywalker is loose in the Senate Building.
Jesse's submarine mission in the future takes a fatal turn with unforeseen consequences. Back in the present, her plan to turn John against Cameron backfires when John discovers that Jesse--not Cameron--killed Riley and he makes a life-or-death decision.
Echo becomes the perfect wife for a lonely internet mogul, and Sierra's attacker is revealed. Meanwhile, Mellie's life is in danger and Agent Ballard's investigation takes a surprising turn when he comes face-to-face and goes fist-to-fist with Echo for the first very time.
Lee is shocked when he finds out that Lucy is thinking about getting married to Pavlov so that he will be able to remain in the country. As Lee attempts to get her to change her mind her family and other friends think that Pavlov is perfect for her.
After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a secret.
Earl works on a list item that deals with a crazy witch lady. Meanwhile, Joy wants to show Darnell her good side.
The truth about Taiga and Ryƫji's feelings for each other finally comes out, and they make a plan to run off together and get married.
Liz gives attention to her building relationship with Drew, and discovers that he has been granted special treatment in life due to his pleasing appearance. Meanwhile, Jack goes all out to re-sign Tracy now that his contract has expired. And Jenna's latest ploy to attract attention is to change her hairstyle.
Daniel and Wilhelmina make Mode's issue based on sex to spice things up. Matt is hesitant to take the next step with Betty. Marc and Amanda provide Betty with a makeover.
Katie is too humiliated from the incident in the woods to leave the house. Lucky she's got Emily to bail her out.
Can torture be God's work? After seven angels are mysteriously murdered, Castiel and Uriel demand that Dean use the agony-inducing skills he learned in Hell to extract information from Alastair.
A disturbed pregnant patient has lost her baby, and Violet must convince her that her baby needs surgery. Meanwhile, Cooper must tell a patient he needs part of his jaw removed due to a fast-growing cancer. Dell must cope with his daughter's absence when his ex has to move for a new job Sam and Addison must hold back their feelings for two unattainable people.
Tess invites Clark to a press conference in New York but when an explosion rocks the private jet they are on, Clark must figure out how to save them without Tess learning his secret. Unbeknown to Clark, Tess orchestrated the explosion to get Clark to reveal his powers. Meanwhile, Davis discovers a surprising way to control the monster within.