With the launch night of the newly redecorated Jockey looming, Jamie and Karen are feeling the pressure in their relationship. The honeymoon period is well and truly over - but can a lesbian encounter put the spice back into their marriage? In the wake of Ian's departure, Micky looks to expand his horizons and enrols on a film course. Soon Micky discover a hidden talent and new friends; his tutor Liz and her husband Ady. The couple soon introduce him to the world of swinging when together they seduce him into their bed. An accident sends Carl to hospital where he takes up a job and is befriended by auxiliary nurse Maxine. Maxine is introduced to the rest of the Gallaghers, but Carl feels left out when Debbie and Maxine spark up a friendship. Meanwhile Stan's attempts to bond with Chesney and Meena land them in trouble with the police and Norma makes a grim discovery while refurbishing the Jockey. And Mandy meets a new man in the form of Jamie's football team mate, Joe.
Matt becomes envious of Sean and Raj bonding together. Christian and Liz give their relationship another chance. Raj's father pays a visit to see his son.
The gang goes to Klaus' bookshop, but there are traps. Sophie is paired with Zhalia, and Lok and Cherit are paired with Dante, but Sophie suspects Zhalia of being a traitor.
Delavos receives help from Allison when he investigates the murder of his friends sister. But the case is taken into an unexpected direction when when Allison's visions involves the friend's former husband and current spouse. On the domestic front, Bridgette finds herself in trouble at school when she is caught drawing pictures of her teacher in the nude.
Three weeks after the destruction of both Primatech and Pinehearst, and the death of Arthur Petrelli, the now-villainous Nathan returns with a vengeance by persuading the U.S. President and the government to round up all people with abilities, leading to Claire, Ando, Hiro, Matt, Peter, as well as Tracy to become fugitives from the people who were their former allies.
Kyle hits the bar with Josh and Declan to drown his sorrows after breaking up with Amanda. Lori and Jessi bond over boys as Lori uses Jessi's apartment as a bolthole.
Brent and Hank are on the outs after a trip to see their favorite comic book writer goes awry. Lacey's generous donations to the thrift store make the perfect gifts for Karen to celebrate her recent promotion. Oscar and Emma's new home alarm system causes more emergencies than Davis bargained for.
Sam and Mel were caught in an intimate moment when their nephew took their picture, and now plans on showing it around his school.
Standard Diner (Albuquerque, N.M.) • Dell Rhea's Chicken Basket (Willowbrook, Ill.) • Salsa Brava (Flagstaff, Ariz.) Guy Fieri takes an eastward tour of Route 66. In Arizona, a family style restaurant serving scratch made southwest favorites. In Albuquerque an old gas station turned diner making classics. And near Chicago, a joint that s been serving fried chicken on Route 66 since the 30's.
Chuck foils a plan to kill Tyler Martin, an international rock star. Chuck's night out with Tyler leads to trouble. Morgan holds a contest among his fellow employees.
As U.S. troops remain in position outside of Sangala, Dubaku seeks another high-value target using the CIP module. While the entire NSA scrambles to locate the breach, the situation rapidly escalates. Paranoid FBI Agent Janis Gold commands from her post, while Jack, Tony, Renee, Chloe and Buchanan follow leads.
Tired of being treated like a child, Erica confronts the source of her reputation by returning to her Bat-Mitzvah - only this time she will prove herself as a woman.
Following workers at the Pennsylvania SPCA, which rescues more than 10,000 animals each year, including domestic pets, and exotic and dangerous creatures.
Blair comes up with a devious plan to take down her new teacher, Rachel. Chuck has no recollection of what happened to him when he wakes up in a hotel. Nate and Vanessa try to help Chuck fill in the missing pieces of his night. Meanwhile Dan and Serena try to keep their relationship together as Rufus and Lily grow even closer.
Melissa doesn't think Alan's family appreciates him, so she asks him to move in with her and her mom.
As Lucas begins to start casting for his movie, Peyton begins to put together plans for their wedding. Meanwhile, Dan gives Jamie advise when he has his first school crush; Brooke is introduced to the actress that will play her in Lucas' movie; Nathan receives exciting news; and Haley is forced to make a tough decision at work.
Robin, desperate to find a job before she is deported, agrees to let Barney produce a video resume for her.
House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient’s condition continues to worsen, so does Thirteen’s as she begins to suffer serious and life-threatening reactions to the experimental Huntington’s Disease clinical trial. Meanwhile, Cuddy attempts to make House’s life miserable for him in retaliation for his part in her own unhappiness.