Blair comes up with a devious plan to take down her new teacher, Rachel. Chuck has no recollection of what happened to him when he wakes up in a hotel. Nate and Vanessa try to help Chuck fill in the missing pieces of his night. Meanwhile Dan and Serena try to keep their relationship together as Rufus and Lily grow even closer.
Melissa doesn't think Alan's family appreciates him, so she asks him to move in with her and her mom.
As Lucas begins to start casting for his movie, Peyton begins to put together plans for their wedding. Meanwhile, Dan gives Jamie advise when he has his first school crush; Brooke is introduced to the actress that will play her in Lucas' movie; Nathan receives exciting news; and Haley is forced to make a tough decision at work.
Robin, desperate to find a job before she is deported, agrees to let Barney produce a video resume for her.
House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient’s condition continues to worsen, so does Thirteen’s as she begins to suffer serious and life-threatening reactions to the experimental Huntington’s Disease clinical trial. Meanwhile, Cuddy attempts to make House’s life miserable for him in retaliation for his part in her own unhappiness.
Sheldon's solution to Penny's financial difficulty leads to a confrontation between Leonard and Penny's ex-boyfriend.
Nine contestants must re-invent their glam drag looks using thrift store clothing and tschotchkes from the 99-cent store. Guest judge Bob Mackie stops by to help RuPaul weed out the drag queen with the least style.
Three weeks after the destruction of both Primatech and Pinehearst, and the death of Arthur Petrelli, the now-villainous Nathan returns with a vengeance by persuading the U.S. President and the government to round up all people with abilities, leading to Claire, Ando, Hiro, Matt, Peter, as well as Tracy to become fugitives from the people who were their former allies.
Kyle hits the bar with Josh and Declan to drown his sorrows after breaking up with Amanda. Lori and Jessi bond over boys as Lori uses Jessi's apartment as a bolthole.
Calleigh and Ryan come close to being murdered while investigating a home in which they find the corpse of a doctor who's been performing illegal transplant operations in his garage...
The body of a man who stole $3 million in diamonds is found in the trunk of a car and the condition of the body makes determining the cause of death impossible.
Brent and Hank are on the outs after a trip to see their favorite comic book writer goes awry. Lacey's generous donations to the thrift store make the perfect gifts for Karen to celebrate her recent promotion. Oscar and Emma's new home alarm system causes more emergencies than Davis bargained for.
Sam and Mel were caught in an intimate moment when their nephew took their picture, and now plans on showing it around his school.
Delavos receives help from Allison when he investigates the murder of his friends sister. But the case is taken into an unexpected direction when when Allison's visions involves the friend's former husband and current spouse. On the domestic front, Bridgette finds herself in trouble at school when she is caught drawing pictures of her teacher in the nude.
George meets another werewolf called Tully, who overstays his welcome.
The negative of “Lez Girls” goes missing; Shane’s incessant apologizing to Jenny finally gets noticed; Alice’s feelings are hurt when Jenny denounces her desire to write a screenplay; Phyllis lets Bette in on a suppressed secret; and it’s opening night at Kit and Helena’s new club, HIT!
After many visa difficulties, Scott and Justin are finally allowed to enter Libya. They travel from Tripoli to Jebel Nafusa, before getting lost in the abandoned city of Ghadames. They wander around the maze of empty streets and homes before finding each other again, and drive deep into the Sahara desert to climb some of the world’s largest sand dunes, and sand-board in their own private oasis.
Bret organizes a gang to protect himself from rappers he dissed in a song; Murray and Jemaine confront a group of Aussie bullies; Mel paints a portrait Jemaine can't get rid of.