A mobster that Warrick had a run-in with is found dead, and Warrick is found at the scene with the murder weapon. However, he insists that he has no recollection of the crime.
When a drunk patient is admitted to the ER, his actions endanger everyone at County. Pratt is still pursuing his dreams of becoming Chief of the ER, and Gates is worried about his future with Sam. Luka unexpectedly runs into Dr. Moretti.
Dawn beats Kyle and May beats Zoey in the semi finals and both have to battle in the finals. In the finals, Dawn faces-off against May in the Wallace Cup. Dawn uses Piplup and May uses her Glaceon. Dawn manages to narrowly defeat May's Glaceon by a fraction. After the contest ends, Dawn earns her second Ribbon! Now that the contest is over, May departs from Ash, Dawn, and Brock once again and goes back to Johto.
To the amazement - and annoyance - of the other three boys, Will wins a Blind Date competition which pairs him off with Charlotte Hinchcliffe, the most desired girl in the school, and he even ends up in bed with her though he keeps his socks on.
Dr. Wyatt refuses to let Meredith give up on therapy. Alex learns something else about Rebecca. The Chief wants Erica to perform a daring surgery. Christina continues to act strangely.
Betty finds her attempts to suppress her feelings for Gio useless when the two end up chaperoning Justin's school dance together. Meanwhile, Amanda agrees to do a reality show with Gene, and Hilda goes out of her way to catch the eye of Coach Diaz. Finally, Wilhelmina makes her return to MODE, much to the distaste of the Meade family.
Michael becomes infatuated with the woman replacing Toby; Jim plan to propose to Pam is upstaged by Andy; Michael gets a surprise from Jan.
When Earl finds out that making up for all the bad things he did to women changes Billie's behavior to the good, he picks the worst thing he ever did to women on his list. Billie wants him to choose between her and his list. When he picks the list, she steals it and starts undoing the items he has already accomplished.
Earl discovers that helping the women he wronged on his list causes karma to improve his marriage to Billie.
Five people with an odd connection go missing from a coffee shop, and the team determines what the connection had to do with their disappearance. Meanwhile, Samantha gets ready for the birth of her child.
Sick of technology ruining his life, Timmy wishes to live in a simpler time. He and all of Dimmsdale are then sent to the Stone Age.
Sayid goes back to the island to bring the rest of the people to the freighter. Ben, Locke, and Hurley go to another Dharma station in order to "move the island".
Toby leaves Dunder Mifflin, and Michael plans a huge goodbye party... out of joy. Angela refuses to help with it, so Michael turns to Phyllis. Dwight and Meredith harass Holly, their new HR representative.
Lex is taken to the Fortress to fulfill his destiny, while Lana awakens from her coma and Chloe is arrested by the government.
Through the 1980's, Chicago's most powerful street gang expanded at an unprecedented rate, with its membership eventually numbering some 30,000. When the city of Chicago wasn't enough territory, the gang spread to other cities throughout the Midwest, like Milwaukee. The GDs quickly gained control of smaller towns using the tried and true methods of fear, intimidation and violence. When the crack-cocaine epidemic hit, the Gangster Disciples were ready to take full advantage. The GD organization operated much like a Fortune 500 company, raking in profits estimated at one hundred-million dollars a year. In 1995, however, everything changed. A federal indictment took down 40 leaders of the Gangster Disciples, including the Chairman of the Board, Larry Hoover. After that, it was every man for himself. Through the eyes of Gangster Disciples we watch the rise and fall of a drug empire as greed and violence wash over an army of Gangsters.
Sam, Dean, and Bobby hunt down Lilith and fight her and her demons in a final effort to save Dean's life.
Toby leaves Dunder Mifflin, and Michael plans a huge goodbye party... out of joy. Angela refuses to help with it, so Michael turns to Phyllis. Dwight and Meredith harass Holly, their new HR representative.
Jerry comes to the aid of his ex-girlfriend when she's collared for prostitution; Carl and Shirley help a woman who's suing the church for prohibiting her from becoming a priest; Denny is wooed by power brokers to run for president.