A spoiled heiress is found dead in her bathtub during her own party, and the investigation puts Horatio on the trail of an abducted young girl. Horatio tells Delko of his marriage plans.
During a heated custody hearing, Todd makes a surprising announcement; Due to a series of unfortunate events, Joan fails to be there for Toni...again.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
Doug crashes Carrie's weekend company retreat, not realising she's blown it off for a relaxing day with her girlfriends.
Hank's new neighbors' son won't stop harassing him, and his parents refuse to do anything about it. So he takes matters into his own hands, which gets him in trouble with the police.
Peter's attempt to open build a movie theater on the Indian burial ground in his backyard releases a poltergeist that sucks Stewie into the television set.
Bree and Andrew finally reach an impasse in their relationship as tension has finally reached a critical point. Meanwhile, Ed finally fires Tom with the pressure from his wife. Lastly, Edie's private detective begins to uncover numerous details of Karl and Susan's relationship as of recently. Gabrielle is having a tough time keeping her servant in the country.
Marge goes on a cleaning frenzy before the housekeeper she’s won the services of comes to the house. One spot remains and she mixes a number of toxic cleaners together to tackle the job. The noxious mixture knocks her out and she wakes up suffering from amnesia. Marge is taken home and the family tries to bring back her memory. She starts to get back memories of her children and other insignificant things, but when it comes to remembering her husband, nothing he does seems to jog her memory. When he can’t get her to remember him, he tries to win her all over again, especially after Patty and Selma get her back out on the dating scene.
Huff's father decides that he will extend his stay, and some family members feel he is wearing out his welcome. Lena asks Huff to address her alternative psychiatric therapy students. Byrd offends some people with his latest art project. Meanwhile, Russell ends up going on a drug-fueled bender.
Paulie finds public opinion turned against him after an amusement ride accident, while Chris tries to start a new life as a husband and father.
The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their unborn baby and the woman's parents who the staff are also treating. The pregnant woman is named Melanie and she will die but her baby may survive. One of the female interns meets up with a woman from her past who is planning on having a family of her own. Cristina is in a good mood although Alex, Izzie, George, and Meredith are having problems but in the meantime Burke hasn't forgiven Cristina for her late night faux pas. Meredith and Izzie are making fun of Callie's household habits and George and Callie are having a fight because of George's roommates. Addison is continuing to own Alex and he's upset about it. Denny has an outburst at Izzie and Derek has an outburst at Meredith.
The escapades of Stan Smith, a conservative C.I.A. Agent dealing with family life, while keeping America safe.
Two weeks before the inauguration, CJ and the rest of the Bartlett administration consider what they will do next. CJ examines her relationship with Danny and considers whether or not to suggest to the President pardoning Toby.
Bubbles starts getting some customers at Kitty Land. Trinity raises a chicken for her science project - Oscar Goldman. Ricky and Bubbles are left in charge, and the chicken escapes. The Boys have to find him before Trinity fails grade 6.
A rampage of brutal machete slayings that target affluent art owners has Detectives Logan and Barek looking for some young suspects who were all raised by Chesley, a strong-willed foster mother. But the case really blows up when Logan unknowingly shoots an undercover cop dead -- and while Captain Deakins sticks his neck out for his detective, a shaken Logan must go eye-to-evil-eye with the manipulative Chesley.
A sportscaster must take on the responsibility of being a full-time dad when his teenage daughter moves in with him.
The 1984 murder of an emergency-room doctor who was shot in the chest in an alley is reinvestigated after a former junkie comes forward with new information. The woman claims she saw a white man shoot the victim, but a homeless black man was arrested for the crime after he was found wearing the dead man's shoes. The probe reveals that the doctor had a gambling problem and was broke. Also, Valens takes action when a suspected child molester is spotted in a park.
In an attempt to destroy the reputation of the Charmed Ones, Billie Christy resort to trying to make the magical community see that the Halliwells only care about themselves. Meanwhile, Phoebe begins to lust after Coop Paige cannot hear her charges' call for help Piper becomes the perfect s housewife.