While a severely burned teenager is admitted and his blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines to prove a former medical school colleague is wrong about the drug.
As the Strike Team is preoccupied with gang violence, Kavanaugh decides to make the Barn his base of operations. An evasive serial killer from Dutch and Claudettes past reenters their life. Meanwhile, additional strain is placed on their working relationship when Tina learns something personal about Julien.
Jack poses as Rossler and manages to trace one of the canisters of nerve gas, but he goes against orders from the president when the terrorists target a shopping mall. Logan and Martha quarrel when she learns of her husband's intention to cover up the real reason for Walt's suicide.
A televised poker cash game in which top pros including Sam Farha, Doyle Brunson, and Johnny Chan compete. This is not a tournament however, each player is playing with their own money and they have the option to buy in again.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
The lives and relationships of a group of siblings and their estranged father Frank Gallagher on a rough Manchester estate.
Aspiring fashion designers compete for a chance to break into the industry in this reality competition. Each week, a designer is eliminated from the competition after exhibiting their work in front of a judges' panel.
Mona and Dee Dee are half-sisters with the same father who didn't really know each other when they were little and are complete opposites, but as adults they live in the same apartment building and at least try to bond.
Darnell's ego is bruised after realizing Maya's paychecks are bigger than his; William is jealous that Joan prefers Darnell for handyman repairs.
Tina continues to struggle with her sexual feelings for men; Kit gives in to Angus; the girls rush to the hospital to be by Dana's side; New York comes calling to Jenny; Moira finds a shortcut to getting male hormones.
A sportscaster must take on the responsibility of being a full-time dad when his teenage daughter moves in with him.
Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.
Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation. Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse.
Season Finale The squad is assigned to protect a civilian convoy. Lt. Underpants leadership skills take a toll on the squad. Back at home, Bo meets somebody who may be able to help him get back in the Army and Sergio receives surprising news from Anna.
Lois discovers she has mono after a visit to the doctor. She then ends up giving it to Malcolm after her maternal instincts begin. As a result, both Lois and Malcolm are forced to spend an entire day and night together in the same room. Hal, meanwhile, is invited to all of his neighbors' parties after they know Lois will not be attending any of them.
Huey has to stop Riley and a small gang of misfit idiots from nabbing the talk show deity, Oprah.
During Chinese New Year, a demon attempts to steal a mystical wooden staff, that's protected by the Zodiacs and they enlist the aid of Piper. Meanwhile, Phoebe enjoys her new place by throwing a housewarming party that gets out of control a monk teaches Billie how to use her power of projection to find her sister Paige tries to get through to Henry about her magical abilities.
Zoey and her friends challenge some stuck-up computer geeks to a robot battle, and recruit Quinn for her expertise. It seems that a win is guaranteed until she overhears Logan making fun of her behind her back, and quits the team. With nobody to help them build their robot, the kids are forced to ask the smartest boy in the school for help, who will only do so on the condition that Nicole goes on a date with him.