William considers leaving the firm as he feels disrespected at work. Maya starts to write a neighborhood newsletter as Joan feels Lynn doesn't like her housewarming gift.
Regina sets Samantha up on a blind date with the man who is refinishing her floors. She turns to Todd for advice when she leads the guy to think she is an avid hockey fan.
Peter travels to Primatech in Texas to destroy the virus, but not everything is what it seems. Hiro continues the pursuit of his father's killer, while Matt pursues the last Company member in the photo. Nikki is reunited with Micah but has bad news, while Maya has to choose to remain with Alejandro, or go with Sylar.
Alan finds out that Charlie stole his girlfriend and works on a plan to get back at Charlie, even though this happened when they were in high school.
Jonesy opens an account at the bank, but he later impersonates the bank's manager from the head office, giving out loans to his friends and rejecting loans from others. Meanwhile, Nikki seeks revenge by playing a huge prank on the Khaki Clones.
Passing by Khartoum, the boys have been riding for a while and see the aftermath of a car crash and pull over to the roadside. One of the drivers explains he fell asleep at the wheel and crashed his truck into another vehicle. Police arrive and are more interested in the bikes than the accident scene. The head of police takes a fancy to Ewan's bike and decides to take it for a test ride much to Ewan's horror.
A mysterious stalker from Adam's past shows up on Wisteria Lane, and they have dinner. Detectives question Gabrielle about Victor's whereabouts. Danielle's baby puts stress on Bree and Orson's marriage. Lynette has a reunion with her long-lost stepfather, Glen. Susan notices Mike is behaving strangely.
Dexter realizes it won't be easy to end things completely with Lila. Dexter tries to stay ahead of the investigations as the manhunt for the Bay Harbor Butcher intensifies. An enemy of Dexter figures out his secret.
It's Thanksgiving and Rose is fed up with everyone. She leaves and they are forced to figure things out on their own. Freddy and Marty Trio use some information to get a holiday furlough from prison.
An unexpected visitor shakes miss Matty, but she keeps it to herself. The rumor that the railway will reach the town ruins the happy atmosphere. When Miss Deborah goes to talk to Captain Brown of this, he is of no help, indeed their friendship is severely strained.
A prisoner, recently released from prison after a five year stay, stalks and then murders a female tennis star. Jessica is guilt ridden for the death since she didn't get the conviction upheld.
Armando's day at work gets sidetracked when he finds an unexpected surprise waiting for him in the dumpster. Spagett!! The Heidecker family shows off their state-of-the-art technology at having fun while Eric's family makes do with a home-made slip & slide.
The team re-opens the 1982 case of a well-liked young man who was shot to death after being accused of date rape by several female college students.
Kitty and Robert takes dance lessons. Tommy gets a surprise visit and Kevin makes a drastic decision.
After Quahog is hit by a flood, Meg winds up in the hospital in a coma. When she wakes up and sees a cute med student, they immediately hit it off. Overprotective of his daughter, Peter is determined to drive the med student away. That is until Meg reveals that she is pregnant.
Bobby gets mixed up with racial intolerance at Tom Landry Junior High. Meanwhile, Lucky hurts himself by catching a frisbee made of barbed wire and the gang has to convince him to go to the hospital.
Xavier thinks that 7 babies were abandoned, so he keeps them as his own. Then he finds out that a woman lost 7 babies and Xavier tries to find the criminal, when it is really himself.