Jeremy meets his hero, techno musician Russell "The Orgazoid". He ends up working as his handyman, which leads Mark to become suspicious, as it seems that Jeremy's job consists of making smoothies for him. Meanwhile Mark meets Sally at his school reunion, one the few girls who actually ever liked him. It turns out that she has married one of Mark's childhood tormentors, Foz. Mark decides to try and seduce Sally whilst Sophie is away on a business trip.
It's Ruby's birthday and Ruby expects her friends to throw her a surprise party at their home. But Ruby must give chase when Max makes off with her birthday tiara.
When SG-1 discovers that Daniel Jackson has been turned into a Prior of the Ori, they must determine whether or not his plan to destroy the Ori is genuine.
When Earl decides to get his first real job at an appliance store, he experiences 'growing pains'. Meanwhile, Joy makes another irrational decision when the forthcoming trial continues to get to her.
Several suspects in a murder case are UFO-club members who believe shape-shifting aliens have been working to conquer the human race for centuries
Xzibit and the boys at GAS transform a 1981 Mercedes-Benz 300SE from clunker to "crunker".
Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.
Lana and Lionel have a secret meeting, after which Lana is shot. While Jimmy is observing photos of the encounter, he is knocked unconscious. While unconscious Jimmy dreams about what life in Smallville would have been like in the 1940s. Clark is a reporter at the Daily Planet, Lana is a siren who planned the demise of her magnate husband Lex, and Lois is a singer at a bar that Lionel owns.
Dean is attacked by a Djinn... and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.
Phyllis walked into the office looking pale and shocked. A concerned staff surrounded her for comfort. She told them she had been flashed in the parking lot. Jim alerted the police and they already had three other incidents of flashing in the area. Michael didn't think much of it, because it was Phyllis.
An old friend of Stark is back. But this time, Stark gets a second chance at justice when he puts Wayne Callison on trial for another murder. Because of the exact same wounds as the previous victim, Callison is accused of murdering another young woman.
Betty struggles with a dilemma as she attempts to bail her family out of a financial crisis while juggling with the task of planning MODE's big assistants week at a medieval-themed restaurant...where Amanda's past ties to the establishment has a link and could come back to haunt her in a surprising way. On the romantic front involving the Meade siblings, Betty tries to give Daniel advice about his endless sexual addiction, while Alexis ponders about whether she should start taking up Rodrigo's offer. Meanwhile, Hilda prepares for her first exam to determine her future at cosmetology school as Wilhelmina prepares for her future plans to take over MODE as she makes even bolder moves for domination behind the scenes.
What is suppose to be a departmental dinner organized by Kovac turns out to be the surprise of a lifetime for Abby when she soon learns it's a surprise wedding, secretly planned by the eager groom. Meanwhile, at the wedding, ER staffers enjoy themselves with music and booze while Neela finds herself the center of unexpected attention between Gates and Ray, which leads to a drunken fight and a shocking conclusion.
The quest for the Enchanted Honey concludes when the gang arrives at Amber Castle, which is the home to a hive of Combee and their leader, Queen Vespiquen.
J.D. tries to get together with Elliot's sorority sister Melody, but she just wants to make out with him without going further. Meanwhile, Keith re-proposes to Elliot after she gets to make everything perfect, while everyone has fantasies about being married to Elliot. Elliot and Carla are having problems figuring out what is wrong with two elderly patients, who show the same symptoms but have no obvious connection.
Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.
A dead woman brings Jordan and Ivers together for a case. Lily and Jeffrey are seeking help from a psychiatrist, who dies in the middle of their session. To add to the mounting stress, Lily suddenly goes into labor; luckily for her, everyone is there to help bring her child into the world.
After Tim and Cindy Devlin's sudden divorce announcement, Andy starts spending time with Cindy, which turns into a relationship, and an urge for Cheryl and Jim to break them up.