When the Tipton holds Health and Fitness week, everyone begins to examine their eating habits. Cody helps Chef Paolo in an attempt to lower his cholesterol, while Carey begins to limit Zack’s sugar intake. Meanwhile, London and Maddie participate in a charity fashion show where they are both criticized about their looks, each taking drastic measures to change.
J.D. and Turk try to treat Dr. Kelso's uninsured friend. Meanwhile, Dr. Kelso himself is concerned about a clothing thief. Elsewhere, Dr. Cox tries to convince Elliot that a reformed drug addict isn't exactly clean, and the Janitor blackmails Carla.
The race between the attending physicians for the Chief of Surgery position heats up after a new competitor enters the fray. They soon realize that the new surgeon, Colin Marlow, was Cristina's professor in medical school and they used to have a long-term relationship. He begins to lie to Burke in order to protect her secret, but is soon faced with the realization that their relationship is on the rocks. George finds out that Callie's family is rich, but she had previously hidden the fact in order to find out whether George loves her for who she really is. Derek treats his former colleague from New York, and forces her to have surgery for brain cancer in order to save her future, no matter what the post-surgery risks are. Alex continues to work with Jane Doe, whose memory doesn't seem to come back. He moves in with Meredith and they have a dinner with her father and stepmother. She seems to connect with Susan, but her relationship with Thatcher seems to be irreparable. Izzie wakes up, realizing that she has slept with George while they were both drunk.
Has nobody noticed that Effy, Tony's little sister, never utters a word? Has nobody ever noticed that she sneaks out at night? Tony has. And Tony doesn't care about anybody or anything - except his little sister.
In the aftermath of Izzie's affair with George, he doesn't seem to remember anything. Callie lets him know that they will be having dinner with her father, but George does not make a good impression, being hung over after last night's events. Alex helps Jane Doe choose how her face will look like after Mark Sloan performs reconstructive surgery on her. He also gives her a new perspective on how the world will see her from then on. The hospital board begins interviewing the candidates for the Chief's position, and Colin Marlow intimidates everyone with his ten-year plan. However, after taking advice from Bailey, Mark seems to have convinced the board that he is appropriate for the job, despite continuous efforts from Derek, Burke and Addison, whose careers in the hospital outlast his. Izzie seeks advice from Addison about her affair, telling her sleeping with George felt right, despite him being married. Mark takes Meredith as his intern for the day in order to impress the Chief, something that Derek doesn't approve of, feeling that Mark has become manipulative.
Clark has second thoughts about Lana marrying Lex, and Lana has the same concerns. Meanwhile, the doctor involved in the secret behind Lana's pregnancy threatens Lex with his knowledge.
10 years after leaving his hometown, Nick Garrett returns to Knights Ridge, to teach a one-day course at Dufresne College, which he believes is a great way to find out what changes since he was gone. After hurting the ones he loved by writing a book, a best-selling novel, and discovering their secrets, Nick will have to find a way to confront past demons and move on with his life. Nick decides to stay after discovering that his ex-girlfriend, Hannah Daniels, has a 10 year old son named Sam who has a peanut allergy...just like all of the men in the Garrett family.
In Memphis, Tennessee, Sergeant Caroline Mason takes it personally when a 75-year-old man is shot dead in her old neighborhood. In Detroit, a man is found dead behind the wheel on Interstate 96 and Sergeant Mike Russell tracks a notorious gang to find the killer.
A fatal automobile accident from 1992 leaves an angry apparition haunting a remote stretch of highway, and Sam and Dean try to lay it to rest.
Daniel keeps secret from Alexis the fact that he is the one who hired Grace to defend their father, something which Wilhelmina uses to bring the siblings apart. Meanwhile, when invited by Henry to Charlie's birthday party, a desperate Betty asks Dr. Farkas, her orthodontist, to be her date. Finally, Amanda catches the eye of an unusual designer who claims that she is his muse.
When Team Rocket was planning their next pitfall trap, their shovels suddenly got stuck in the ground. When they try to pull them out, a Steelix pops out of the ground with the shovels stuck in its head. It grows angry and begins to chase them. Meanwhile, Ash and his friends discover an injured Bidoof. After healing its injuries, they decide to help it go back to its village. However, Team Rocket and the rampaging Steelix come by, forcing them to run into Bidoof's Village. Lucky for them, the Bidoof Village is surrounded by a huge rock wall, but Steelix will be able to break through. Now Ash and the others must find a way to stop Steelix before it destroys the Bidoof Village.
Brennan and Booth have to solve three murders that are identical to the murders in Brennan's new bestselling book.
Claire has an idea to send a message to the outside world. Charlie, however, is resistant to the idea, and Desmond tries to sabotage the plan. As Claire tries to get the truth behind their actions out of the pair, she remembers traumatic events from her past. Meanwhile, the rescue party encounters a dangerous obstacle.
After a company of Marines show up, the town of Jericho has hopes that life will finally start to return to normal. However, their behavior raises Jake's and Johnston's suspicions.
How do racing drivers survive 300 kilometres an hour crashes? See how impregnable bank vaults are made, and how do they tell the time?
See how the California Highway Patrol stop a speeding car, and how 75,000 litres of water is shot 24 stories high in a spectacular display?
Butters' dad sends him off to special camp to "Pray the Gay Away" when he believes that his son is bi-curious after catching him in a compromising position with Cartman. Meanwhile, Cartman does his best to retrieve a photo of him in that compromising position before too many people find out about it.
When Jordan autopsies a body that William Ivers orders her not to, she unexpectedly discovers a biohazard that has the entire city at risk. Jordan sweats out getting test results when she suspects she is also infected. Meanwhile, Bug’s concern is for a pregnant Lily who has come into contact with the mystery virus…and can’t take medications.