Earl wants to use his birthday to look back on all the good he's done over the past year, but at his party, everyone seems to want to talk about his past misdeeds instead.
Happy-go-lucky party animal Chris wakes up one morning to find his mum's gone away for a few days and left him a grand. But what do you do after you've thrown a party to end all parties and blown all the money?
Meredith is still underwater, but nobody seems to notice. Her worsening condition makes her rescuing an urgent matter. Derek finds her coat on a man she had helped, and starts looking for her and, much to his shock, the little girl Meredith took care of suggests that she is in the water. Derek saves her, but she is almost dead, due to hypothermia. Izzie has to perform brain surgery on a man stuck between cars, as he begins to experience seizures. She drills holes into his head, perforates his skull and ultimately saves his life before he is rescued and transferred to Seattle Grace Hospital. George lies to the woman whose son he had been looking for, in order to get to surgery, but still doesn't have any luck in locating him. Alex finds no hope in searching for the pregnant Jane Doe's family as she undergoes surgery. The interns find out about Meredith's situation and express their hopelessness. She wakes up in what appears to be limbo and meets her deceased acquaintances.
A boy named Tobias was blinded by the meteor shower but given the ability to identify other meteor freaks. Lex is using Tobias to locate other people with abilities so that he can perform experiments on them. Lana learns of Tobias and is fearful that he will name Clark as a freak, so she offers him a cornea transplant to keep him quiet. But Tobias has some surprising news.
The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.
Roy stopped by Pam's desk to let her know how excited he was to see her art show. She reminded him that it was just a small show being put on by her art class. Pam later admitted she was very happy she was back together with Roy because it showed maturity. Jim feigns indifference to the reconciliation.
Daniel reconnects with Grace Chin, a girl he once stood up for a date in college, and who is now New York City's top lawyer. Meanwhile, Betty befriends Charlie, an out-of-towner she meets at the Mode cafeteria, whom she later discovers to be Henry's girlfriend.
Kovac and Gates find themselves with a moral dilemma when a woman comes into the ER with acute liver failure; Neela finds herself questioning what is right when Manish decides to give up a kidney to a complete stranger. Meanwhile, Ray fights to get to the bottom of a cheerleaders accidental fall; Abby gets a prediction for her future; and Alex's troubles continue to intrude on Sam's work life.
As shocked as she is to be called the c-word by Lutz, Liz is more horrified to realize he may be right. Meanwhile, Jack brings Tracy to a charity golf event to get closer to the chairman, however his plan backfires when Tracy acts too much like his uncensored self.
A Croatian Doctor comes to Sacred Heart, only to find out that he has to redo his Internship there. J.D. shows symptoms of 'Vasovagal Syncope', a condition that causes fainting and blackouts. Turk and Elliot argue over whose turn it is to take care of him, whilst Carla tries out her new excuse "I have a baby" and the Janitor takes a vacation.
Waking up from a dream that allows a mysterious woman calling herself Sandra to take possession of her body, Allison is freaked out and sneaks out of the house. Joe seeks Scanlon's help when her new identity refuses to leave her body.
In the shocking third season finale, unexpected visitors threaten to jeopardize the status of the competition. Meanwhile, as the final two teams prepare for the final showdown, they reveal sides of each other that they've never shown before, and one teammate makes a decision that turns the competition upside down and leaves everyone in shock.
Since her mother and lawyer have turned on her, at her trial Benny must rely on George's testimony.
Mac may have a difficult time solving the murder of a music mogul the sister cleverly uses a lie detector test to cover up the crime. Stella wonders if she has HIV due to an accident.
Due to racial comments from Coach Mac, the black players on the team refuse to play unless he is sacked.Julie is sucked deeper into the vortex as her friendship with Tyra develops. Matt tries to win Julie back.
After Desmond rescues Claire from drowning, Charlie gets Hurley to help him find out why Desmond has seemed able to predict the future. Desmond recalls exactly what took place in the moments after he turns the key, where he experienced a strange vision of his life prior to his Army days.
Haley confronts Brooke regarding the stolen calculus test. Lucas and Peyton consider taking their relationship to the next level as Peyton and Brooke grow closer. In Deb's absence, Nathan throws a senior party at the Scott House where a sex tape from Nathan's past surfaces.
The BAU becomes involved to prevent a possible race riot when the murder of four young black women in a mostly white New York suburb appear to be hate crimes.
Booth and Brennan investigate the death of Terence Bancroft, one of the Jeffersonian's major donors, found dead at his home. Hodgins' relationship with the wife of the deceased years earlier, compromises the case.
Keith takes on a second concurrent murder case when the head of the Hearst basketball team turns up dead and his son is the prime suspect. Meanwhile, a depressed Logan refuses to leave his hotel room and ends up babysitting Dick's girlfriend's little sister for days.