Matt enters the private security business and receives an objectionable client. Suresh finds another person on the list. As her home-life worsens, Claire strives to learn more about her birth parents. Hiro and Ando get sidetracked in Vegas again while searching for the sword. Nathan is forced to deal with a secret from his past. Still indebted to Mr. Linderman, Jessica resorts to unsavory methods that could spell doom for a fellow hero.
While Eddie and Jen are walking around the neighborhood, they discover an abandoned baby in a dumpster, and become consume in finding the parents. Lizzie's first crush is one of Tay's friends. Eddie also has trouble dealing with Cassie's feelings for Charles.
John and Denise Bruno have their hands full with their four girls. Dad's got issues with the two teenagers, Mariah (15) and Taylor (13), while Mom's fed up with the two youngest, Bella (6) and Sam (4). Mariah was born with fairly severe cerebral palsy and gets daily physical therapy from Mom, but she has no physical contact with Dad, as he no longer helps her out with her therapy. Mariah craves her dad's affection. John, a very traditional dad, doesn't approve of teen Taylor's punk-goth style and strong-will; they are constantly butting heads. The most difficult part of the day for Denise is when she's trying to do therapy with Mariah and the little ones interrupt and distract them. The girls' tantrums and demands have driven Denise to the end of her rope. Jo's faced with the challenge of saving Dad's relationships with the two oldest girls, especially Taylor, before they're too far gone, and getting Denise to demand respect from the little ones and keep them from interfering with her therapy time with Mariah.
When it's time to plan a party for Jeff's birthday, everyone gets involved. But Audrey is spending a little too much time on planning the party, which makes Jeff unhappy. Alhough Jeff won't reveal what he usually gets in the annual birthday deal, Adam brings up the subject with Jennifer and is then worried when Jennifer not only agrees to give him a birthday deal, but announces she wants to get one in return. Meanwhile, Russell is obsessed with trying to figure out what Jeff's birthday present really is.
Karen and Lacey move their friendship up a notch by no longer asking when they borrow things from each other; Oscar, Emma and Wanda decide that Brent needs to expand his horizons, movie-wise, so they prepare to show him his first horror flick; Hank decides that he needs to have the contents of his truck with him at all times, and comes up with a novel solution.
The murder of a Police Commander and his wife puts Walker, Connor and the team under pressure to get a quick result. Jewelery has been stolen from the house, which would indicate a burglary gone wrong, but several relatives profit from their deaths and so they focus the investigation on the family. Connor is suspicious of the identical twin sons in particular and suspects that they may have worked together in order to get away with patricide.
Harry loses his cool with 3 swimmers that he's forced to rescue just seconds after warning them not to swim in a dangerous area. However, calling them "imbeciles" and "idiots" puts him in hot water.
Horatio has Eric rushed to the hospital and watches as the doctors try to revive him. The rest of the CSI team finds evidence that may lead them to Cruz.
Maya and Darnell meet a man they suspect is abusing his wife. Joan finds out Aaron does not believe in celebrating Valentine’s Day.
Spencer refuses to let go of Heidi. Meanwhile Lauren and Whitney are on the spot, because "super-intern" arrives at Teen Vogue.
Rose is moving to London, and Charlie is surprised by his reaction to the news. Alan lies to a woman he met online.
Cross Over Episode with Las Vegas Danny and Delinda, from the show Las Vegas, are vacationing in Boston. It does not take long for their vacation to turn into a crime-solving trip while helping Jordan and Woody, track a killer. Elsewhere, Bug is working the case of a woman found in the Charles River…her watery grave since the 1980s. Also, a pregnant Lily returns to the morgue and identifies the baby’s father.
Nora has a Valentine's Day dinner with a friend and takes a risky ride that could land her in trouble.
When Bobby's snakes gets into the toilet Hank decides to call Animal Control. But instead of taking care of the problem they make the city believe that the problem is worse than it is causing panic. Now it is up to Dale to save the city.
Sandy starts falling for a handsome doctor, and Martin may not be able to handle it. Elsewhere, T-Bone and Ruthie want to do something romantic for Valentine's Day, and they profess their love for each other in an unusual way. The Colonel and Ruth drop by unexpectedly, prompting Lucy and Kevin to leave town, and Eric fears that his parents know about his health problems.
When Roger is rejected by Steve, who seems to be over him, Roger heads out in search of a new human companion. But when this new friend starts to abuse Roger and the relationship turns into a lot of excuses and sorry's, Steve and Hayley scheme to get Roger out of the bad relationship and back home where he belongs. Meanwhile, Stan tours the Mr. Pibb factory and meets the man himself.
Lisa pretends to be Native American for multicultural day at school. Meanwhile, Bart finds love with an older woman.
Ian proposes to Susan. The Scavo pizzeria prepares for its grand opening. Mike visits a hypnotherapist in hopes of remembering Monique. Gabrielle's romantically interested in a lawyer, but he's working for Zach who wants her for himself. Bree is hospitalized after a fall, after being tricked to climb on a ladder to retrieve Monique's teeth.
A series of ritualistic murders starts to look a lot like werewolves so Harry, of course, gets dragged in. Thing is, it looks like the lycanthropes aren't the killers... they're the victims.
After Peters dad, Francis, dies, Thelma tells him that his real father actually lives in Ireland. So Peter and Brian decide to head there in search of his father, who ends up being the town drunk. They decide to play a drinking game to prove his paternity. Meanwhile, Stewie acts out and Lois spanks him. Realizing that he likes being spanked, Stewie does whatever he can to get into trouble.