Charlie writes a children’s song and finds success as Charlie Waffles. The children love him and the mothers seem to as well. Charlie's new found fame irritates Alan.
Raj's parents set him up on a blind date, but just when he discovers he can talk to her, she shows interest in Sheldon.
Chuck must learn to balance a real love life with his cover love life when he meets a charming young woman by the name of Lou. At the same time, his relationship with Sarah gets interesting when the duo must explain their sexual relations with Ellie and Captain Awesome on a double date. Meanwhile, there is trouble when someone is using truth poison in order to retrieve codes for nuclear facilities.
Nancy has another full week of trouble to deal with and Doug isn't helping. Heylia teaches Celia.
Marshall awaits his bar exam results; Ted introduces his latest girlfriend to the gang, who all see the flaw that Ted has missed
Susan jeopardizes Michael's life as she puts her own escape plan into motion. Whistler's past catches up to his girlfriend.The Company goes after Lincoln and Sucre. Justice prevails for Mahone. And Lechero sheds light into an empty tunnel.
Greg comes to stay at Chris' house while his father is out of town but Chris starts to have regrets. To make extra money, Julius drives taxis in his spare time where one of his customers turns out to be a fugitive.
Lauren and Whitney have to cover an event for Teen Vogue, where Lauren runs into Heidi and of course they fight again. Later on Heidi tries to make up to Lauren, but Lauren turns her down. Meanwhile Audrina and Justin still struggle in their undefined relationship.
A news report on a couple looking for their missing son, Ashley, brings a surprise for Sarah Jane (Elisabeth Sladen) when she discovers that the missing boy looks exactly like Luke (Tommy Knight). And when Mr Smith (Alexander Armstrong) confirms that Luke is a genetic match with Ashley, Sarah Jane sends him back to live with his 'parents'. With no knowledge of his former life, Luke finds it hard to fit in and, when he tries to escape, he makes a startling discovery about who his parents really are. Sarah Jane, meanwhile, makes some investigations into the Pharos Para-Science Institute – a research unit that has been conducting experiments using alien technology. Floella Benjamin guest stars as Professor Rivers.
Caitlin falls in love with two different guys named Vince and Blake at the same time. Meanwhile, an old bickering couple get a new job at Burger Mcflipsters with Wyatt (Harvey Atkin guest stars as George Bickerson.)
The biggest pot in televised poker history on this episode of High Stakes Poker that features Antonio Esfandiari, Sammy Farha, David Benyamine, Patrik Antonius, Guy Laliberte, Jamie Gold, Barry Greenstein, and Doyle Brunson.
The events of the "missing four months" are explored. Maya and Alejandro must go on the run, it is explained how Peter ended up in Ireland and what happened to Nathan, Nikki, and D.L.
The Walkers unite as Justin's addiction hits an all-time low. Kitty and Robert build new plans for their future.
Presumed dead, Lois returns from the wilderness and names Stewie as her killer. On the lookout for Stewie, Joe leads a manhunt around Quahog. Desperate to stop Stewie, Lois realizes what she must do.
When the family goes out to a restaurant where the food is cooked at the table Cotton throws a tantrum and gets into a fight with the chef. The fight leaves Cotton near death in the hospital.
When a boy named Percy wishes he could impress the Loco's with his mascot outfit, he has Xavier pretend to be him in a costume. The Loco's decide to let Xavier lead them for a while and things get a bit out of hand.
The mayor places undue pressure on Sebastian and his team to identify, locate, and convict a serial freeway sniper who is causing city-wide panic in Los Angeles.
Larry uses Sammie Greene's bat mitzvah to try and clear up a nasty rumor about him; the Blacks announce they're returning home; Larry makes another attempt at dating.