Following Christine's breakup with Burton, everyone expects Christine to fall apart emotionally, but she insists she is fine and looking forward to spending time with her best friend: "me." But after being humiliated while dining out alone, Christine realizes she really did care for Burton, which drives her even crazier.
In an effort to recreate the missing piece of the tattoo, Michael gets transferred to the psych ward, seeking the help of Haywire. T-Bag and C-Note have to join forces.
A sportscaster becomes a full-time dad when his ex-wife decides to accept a job out of the country and his teenage daughter, Breanna, moves in with him.
Melanie becomes jealous when Derwin hires a sexy image consultant who appears to be more than willing to do anything he asks. Joan worries whether Melanie will be able to balance medical school with life in the NFL.
Allison investigates apparently random killings, endangering her family in the process. Bridget has to do a class presentation about her mom's job.
Eric Camden, a minister, and his wife Annie deal with the drama of having seven children, ranging from toddlers to adults with families of their own.
After finding out her rival will be writing her six-month performance review for the agency, Dee Dee makes an effort to tighten up her relationship with Brett outside the office. The two have a little too much to drink one night and wake up the next morning in Dee Dee's apartment clueless as to how they got there. Mona and Spencer trick Adam into thinking he won a sweepstakes.
Tim Wujcik and his wife, Toni, seem to have it all -- he's a great provider, Toni's the hard-working stay-at-home mom, and they have three beautiful children. But they need what money can't buy -- mutual respect among all family members and a tranquil home life. Instead, the older boys -- Alec, 6 and Bryce, 4 -- are wantonly destructive with their many toys, and aggressively defy Mom's efforts at discipline. Baby Carly, 1, is learning all the wrong lessons from her older siblings, and Toni swings between being too timid with her kids and too harsh when she's had enough. Tim admits that he's the fourth child in the family -- undercutting Toni's efforts at discipline and instigating trouble with the kids. His preferred method of discipline is to "reason" with the children with lots of talking, but it isn't working. Dad needs to grow up fast and Jo Frost is on the scene to help.
A car in which five years ago a teacher was murdered is returned to the victim's husband. Pullman re-opens the unsolved case, hoping her team can track down the dead woman's secret lover, and a clue soon leads them to a male prostitute. Pullman had worked on the original case and been troubled throughout by the lack of emotion shown by Nancy's husband Stephen
A pro baseball player is accused of rape. Nigel sets out to find the family of a fighter pilot who was been discovered…frozen. With the relationship of Woody and Lu growing, Jordan’s jealousy grows.
After a fire burns down Sushi Rox, Zoey and the gang hold a people auction to raise money in order to rebuild it. Chase and Michael get auctioned to the sushi-crazy gym teacher. Zoey, Lola, and Nicole become Logan's personal cheerleaders, and they are told to "cheer his awesomeness", as in cheer for everything he does. His plan backfires when the girls decide to cheer for everything he does.
DI Gil Mayo and his team investigate the death of a geography teacher and uncover gambling debts and drug dealing.
Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.
Reese meets a cute vegetarian named Carrie when he goes back to work at the meat plant. At first, he goes along with her political talk, but she catches him with a pork chop. So, to get Carrie back, he sets free all the cows at the meat plant. Malcolm, meanwhile, tries to fool Lois in order to attend a rock concert.
Jill's new treatment for juvenile diabetes is halted when she discovers than the stem cells hold a retrovirus that might endanger the patients. The research on what plagues the girl found in the subway tunnel continues.
Tony seeks guidance from overseas to solve a local problem; and decides whether a top earner deserves another chance.
Huff's romantic weekend alone with Beth ends up getting very steamy. Izzy meets a man while at a Palm Springs casino. Byrd ends up breaking into a neighbor's house and is caught.
Bill attends the funeral of Frank's first wife Roberta at Juniper Creek, and strikes a deal with Roman. With Roberta out of the picture, Bill's mother Lois attempts to rise up on the social ladder at the compound, and Barb and Nicki find themselves in a hairy situation at Henrickson Home Plus.
After Paige and Henry leave for their honeymoon, Cupid "Coop" takes Phoebe on a journey through her past romances in an attempt to revive her excitement for love. Meanwhile, a group of magical teens, who are protégés of Leo, come to the manor seeking refuge from demons that have overtaken the Magic School, forcing Piper to take charge. Billie and Christy's parents come to town for a visit, but Christy refuses to see them in order to test Billie.
Former series regulars, including Marlee Matlin, Mary-Louise Parker, Tim Matheson, Anna Deavere Smith and Gary Cole, make guest appearances as Bartlet, Santos and their staff members attend a funeral for one of their own. Also, Josh cautions Santos about getting involved in the vote for Speaker of the House.