On their way to Ritchie's desert camping trip, Christine, Richard, Matthew, and Barb stay at a seedy motel and get on each others' nerves.
A family feud erupts when a rich and lonely old woman, Dorothy Hepple, is found dead in her home. Dorothy leaves all her money and property to her beloved cats, rather than her nephew, Harry, and niece, Caroline. Her body lay undiscovered for two weeks and the cause of death is undetermined, but the fact that her cats were deliberately locked in the house, forcing them to start eating their owner's remains and any evidence, makes Jack suspicious. There appears to have been no love lost between the late Ms Hepple and her neighbour, Tim Cuswell. Meanwhile her carer, Dale , seems to have been devoted to her, his motives are questionable. When the last of Dorothy's feline beneficiaries dies, her estate suddenly comes up for grabs. With no shortage of people laying claim to the estate, the team decides to reopen the investigation into Dorothy's death.
Five teenagers must locate and secure ancient relics with unbelievable power, while at the same time stop a demonic corporation who want the relics for their power.
Carrie's ecstatic when an affordable apartment opens in Manhattan, but Doug's reluctant to leave Queens. Arthur meets singer Ava St. Clair.
A missing computer circuit board: the Russians get wind of Chinese espionage, the White House must find a leak, and CTU interrogates an unlikely witness.
Jake gets lucky after Charlie takes him to the racetrack. Meanwhile, Alan has a difficult time at the DMV.
Hiro and Ando's trek into the future leads them to meet some of the heroes as they are five years later, after the nuclear fallout. This includes a darker side of Matt, a Jessica/Niki with a clear winner in their battle, a brown-haired Claire, and a man named Andy, who's a big hearted Texan. It also features an event at an upscale gentleman's club.
When Chris secretly listens to his parents' comedy albums, he discovers that telling dirty jokes to his classmates is the key to popularity. Drew has to deal with an unwanted admirer in the neighborhood; and Rochelle decides to find her mother a man.
Thinking that Bob Barker may be his father, Barney is overjoyed to be a contestant on The Price is Right. Marshall and Lily try sleeping apart prior to the wedding.
Bart goes from hero to goat on his Little League team after an error in the championship game. Meanwhile, Homer falls asleep on a bed in a department store. When he's awakened, he raves about the mattress and is given a job as a salesman.
Susan goes to the therapist and realizes she must choose between Ian and Mike. Travers is having a birthday party which only spells trouble for Mrs. McCluskey, Gabrielle's engagement party is upstaged by an unexpected announcement and the neighborhood is full of gossip about the dead body found on Wisteria Lane.
Vicki and Henry have a run in with Medusa, the gorgon of Greek lore. While looking for a missing male model.
Maria Spatafore requests help from Tony for Vito, Jr. Tony's bad luck puts a rift between he and Hesh. A.J. makes a major choice regarding his future.
Lois gets a job as the church organist, so the family decides to begin going back to church. When Stewie gets sick after receiving communion, the congregation becomes convinced that he has been possessed by the devil. While on the run, the family ends up in Texas, where Peter begins to fit right in with the cowboys, Stewie enters the "Little Miss Texas" pageant, and Chris and Meg sneak into George W. Bush's house.
Henry is shocked when he learns that his ally, Emperor Charles V of Spain, has released France's King Francis I from prison. He's equally surprised when Anne Boleyn turns him down after offering to make her his sole mistress.
Kimball tries arresting a magician performing without a permit, who cano get out of whatever restraint she places on him. Dangle accidentally releases a child killer free. A customer wants to file a complaint against the brothel for fraud. Junior and Jones deal with a drunk at a Renaissance Festival.
Mayko tries to get rid of the pain she's feeling in her phantom limb; the team investigates the high level of mercury contamination found in Lake McGraw.
After Stan discovers that Francine has a secret sex garden, he feels like their marriage may be crumbling. Looking to rekindle their romance, Francine asks for a divorce so that Stan can experience life as a bachelor again, and both learn a valuable lesson in love. Meanwhile, addicted to an energy drink, Steve finds himself panhandling in the streets to support his new habit.
On 2 June 1983, a fire breaks out on Air Canada Flight 797 in the aircraft's toilet. An emergency landing is made in Cincinnati, but the aircraft is engulfed by flames on the runway, killing 23 people, including musician Stan Rogers. The opening of the aircraft's doors after the landing caused a flashover.