Mike heads to the site of a future California neighborhood where he learns that there's more to erosion control than one might think. Then Mike gets a bird's eye view of Palm Springs as he helps maintain and repair the tram 8,500 feet above the city.
Samantha is suspicious about Regina's action, which lead her to believe she is having an affair. But she's not alone. Todd is cheating on Chloe, who is none the wiser, with Samantha. Dena and Regina are contemplating opening up their own coffee shop.
Georgina informs Serena that she can reveal a deep dark secret from Serena's past, but no one is prepared for what Georgina does next. Blair and Jenny's power struggle continues when each of them start spreading scandalous rumors about each other on Gossip Girl. Dan sees Jenny's new beau, Asher, cheating on her, but Jenny won't listen to him. Rufus goes to Lily for advice on how to handle Jenny's new behavior. Serena tries to confront Georgina, but she leaves before Serena has a chance. After this, Serena says that she and Georgina are not friends.
The rest of the gang fall for Sheldon's twin sister, and Leonard's plan to win her heart is derailed when Sheldon declares he'll be the one to decide who can date her.
Lucas investigates Dan's heart condition. Haley struggles with letting Dan into Jamie's life. Peyton also still struggles with her guilt over Lucas' breakup and Mouth finally gets the chance to be a sports anchor.
The crew of the Hammersley are joined by a federal agent and go in search of an illegal fishing boat. Whilst on board the Navy find evidence on the boat and find the fishing boat crew start to exhibit symptoms of bird flu. One crew member faces a gruesome operation, while the federal agent learns that blackmail can work both ways.
Barney gets a new wingman and Ted meets Stella's daughter.
House is convinced one of the actors on his favorite soap opera “Prescription Passion” has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House’s assessment and do not believe there is anything wrong with him.
Allison has dreams that help Scanlon in his search to find out who killed a wealthy local drug dealer. Allison and Scanlon are dumbfounded when Allison's dreams lead them to a severely impaired man with a bullet stuck in his brain. Meanwhile, Joe's partnership with Meghan Doyle is put in jeopardy.
While Lo and Lauren enjoy living at the house, Audrina feels more and more left out. Meanwhile Stephanie thinks it's time to get rid of Spencer and Heidi prepares her next step in her career.
Moz is a drug dealer and has very strange clientele who come and go from his flat.
Dani faces a tough decision: Noah or horse racing, and Matt and Kris find running the dude ranch difficult. Later, while searching for two missing children, Matt and Junior argue.
After outing himself as an alien, Roger (in disguise) finagles his way into being appointed the CIA's chief alien hunter to take advantage of a lavish expense account--while coming up just short in attempts to catch himself. Meanwhile, Francine shocks her family by displaying a prejudice they never knew she had.
Susan meets her ex-husband, Karl at a Lamaze class, and finds out that he has remarried and is having another child. Lynette learns who was responsible for starting the fire at Rick's restaurant. Bree wants Orson to turn himself in to the police. Meanwhile, Gabrielle rents a room to a hip artist, Ellie, who has a dark secret. Elsewhere, Dylan continues meeting with her father, Wayne, and Katherine decides to go spy on her.
Lisa makes a film about her family that gets accepted by the Sundance Film Festival, and the Simpsons go to Park City, Utah, to attend.
David ignores protocol and hires his new lover, Enuka; Mayko is contacted by the parents of a sick child who believe she's the only one that can help.
A drug addict mother, who lost her son in an apartment fire in 2005, comes forth claiming she just saw the same child in the park.