The serial killer continues the killing spree, and leaves a clue: the victims and their fates are inspired by the circles of Hell in Dante's Inferno.
Michael Scofield, a structural engineer, attempts to rob a bank in order to get incarcerated at Fox River State Penitentiary, where his brother Lincoln Burrows, accused of murdering the Vice President's brother, is scheduled to be executed. At Fox River, Michael approaches a number of inmates, all of whom play an important role in his plan to free his brother from the inside. Meanwhile, agents Kellerman and Hale are determined to make sure the execution goes through as planned. Lincoln's son LJ gets into trouble.
Michael seeks help of his fellow prison inhabitants to execute his escape plans.
Nancy gets a rude awakening when her brother-in-law Andy comes for a surprise visit. Doug has an idea for a location for the faux bakery, which Nancy may need more than ever with Andy in the way. While Andy wreaks havoc in the Botwins' lives, Nancy is introduced to "The Candy Man" in order to help meet her customers' needs, and Celia drops a bomb.
When Kris has an opportunity to train with a famous female jockey, she neglects her school and work responsibilities. Matt's gambling problem is discovered by others. Dani renews her search for the truth behind her mother's disappearance.
The Fugitive Task Force races against the clock to apprehend a psychotic child killer after he escapes from a mental hospital and abducts another victim. As Connie and the team go after the killer, Jimmy McGloin is haunted by an event from his past that could compromise the investigation. When his daughter goes missing, Connie faces a nightmare of his own.
Discovering that NTAC is behind the disease plaguing the 4400s, Tom and Diana try to get to the bottom of NTAC's cover-up, while Kyle considers turning himself in.
Eager to return to Rome after eight long years of war, Gaius Julius Caesar ends his campaign with a resounding triumph in Gaul, and news of a shattering personal loss at home. In Rome, Caesar's old friend Pompey is counselled by the Senate, who worry about Caesar's growing popularity. Two soldiers are enlisted to find the army's stolen gold standard. Atia is careful to play both sides of an escalating power struggle.
When the team arrive at a van abandoned on landfill sight they soon realise this is a case, the like they have never seen before. The van door is locked, the glass darkened, an angry buzzing inside. Phoebe is in the front seat, wasps crawling in and out of her open mouth: SAVE ME is written in blood on the windscreen. Red's analytical skills are stretched to the limit as he tries to fathom the workings of the mind of a killer determined to create their own Hell here on earth.
When Stillson's girlfriend disappears, he must reluctantly turn to Johnny Smith for help in locating her.
Calvin and Jen have dinner with David and Dana Kang (Kipp Shiotani, Lauren Tom), who are constantly cursing at each other in public. Michael Kang (Yun Choi) breaks up with Terri, while Isaac begins seeing Michael's sister Michelle (Camille Chen). Eddie picks up a gorgeous woman (Sheryl Lee Ralph) in a bar.
Vince is blinded by love, and Eric gets cozy with Sloan. Meanwhile, Ari gets shot down in the war room, and Drama and Turtle use their paparazzi skills on an important spy mission.
Carey needed some help, so Mr. Moseby ends up taking Zack and Cody to a baseball game. Mr. Moseby get into some trouble due to an incident at the game. London sets Maddie up on a blind date, in which Maddie ends up having a really bad hair day.
Lloyd realizes that the high school's time capsule could return the Diffy's to the future.
Solomon Grundy, a legendary zombie, emerges from a swamp on Halloween to wreak havoc on Gotham. But Batman and Alfred discover that there is more to Grundy than there appears.
The Autobots search for Jolt and the kids who have been kidnapped by Sideways and Starscream, but Megatron has discovered new information regarding Unicron's dark power that could alter the effects of the war.
SG-1 investigates when evidence suggests that there are still Goa'uld hiding on Earth -- including a former System Lord. Tensions between Earth and the Free Jaffa continue to mount.
When Team Impossible demands that Kim cease her duties as a teen hero, Kim is caught between a choice to live a normal life or continue to help save people. However, even should she decide to keep saving the world on a regular basis, can she outmatch three of the highest paid heroes in the world who have everything at their disposal, even their own theme song?
The team discovers a young Wraith girl who has been raised by a human, and is in hiding from the people of her human village in fear of her life.
Adama heads to Kobol to find Roslin, reassembles the fleet and heads down to Kobol himself to find the presidential party in search of the "Tomb of Athena" which allegedly leads to Earth. Apollo hangs out with Starbuck , Zarek tries to keep his cronie off plotting with Boomer who is unaware of tension building between Helo and Tyrol.