It's confrontation time in Tree Hill, as Lucas confronts Peyton about her nasty behavior towards Lindsey and Brooke must confront Victoria about meddling with Peyton's record label. Meanwhile, Nathan begins to grow closer to Carrie, Haley continues to struggle in dealing with Quentin, and Mouth must choose sides between his co-workers and Alice.
Eden looks to Sean for help after getting into business with Kimber and Ram. A group of wealthy socialites hire Christian for all of their cosmetic surgery needs. Sean discovers another side of Colleen.
A mishap with baby Katie and a bag of Es leads to a standoff between Mandy and Frank. When the family back Mandy, Frank is forced to leave the house and ends up sleeping rough. Meanwhile, when Liam learns he's going to be nappy changing for Monica's new baby, he decides to run away. He catches up with Frank and the two outcasts bond over a camp fire and a leaky tent. Micky's attempts to get into his dad's good books go horribly wrong when he accidentally loses the weekly drug pick-up distracted by a hot guy from the local abattoir. He enlists Ian's help to get them back and the two lads go on an epic search until Ian gets caught by the thieves and Micky has to decide whether to save his friend or his own skin. Shane is delighted when Kellie finally admits that she loves him and he invites her round for Sunday lunch with the family. But Paddy is not happy about sitting round the table with a prostitute and decides to pay Kelly a little visit...
Against the wishes of Pablo and Jean, Kris makes the decision to remain with Wildfire to care for his injury.
Michael's escape may be in jeopardy because of heavy rain. T-Bag and Lechero join forces, while Bellick hopes to do the same with Mahone.
Granddad worries about Riley's sexuality when he notices that he begins to dress and act like "in-the-closet" rapper, Gangstalicious.
While searching for some stolen cargo, John becomes separated from Sarah and Cameron. Meanwhile, Agent Ellison's murder investigation leads him to a surprising suspect.
Phineas enters a thumb-wrestling competition with a local bully, while Doofenshmirtz creates a hypnotic device to control people's minds so they will sing him Happy Birthday.
Hank starts up a new business, and gets some unwanted help from Oscar, but it's Karen's help that really make things take off. Brent tries something new, but finds only embarrassment. Lacey and Davis play the real estate market, until Davis decides that play time is over.
Ashley learns that Craig's debut album includes a song she wrote, but was not given the proper credit. Therefore, she decides to go back into music, but finds herself outshined by Jimmy.
Paul is surprised when Laura makes a revelation regarding her boyfriend.
Maya and Darnell consider adopting a child while a neighborhood meeting presents them with the chance
Christine and Mr. Harris try to establish a relationship before having sex, but Barb gives her pause. Matthew is horrified when he sees his med school cadaver was a neighbor.
Amanda's presence puts the Tragers into an awkward position when a social worker comes to evaluate their fitness to take care of Kyle.
The Aqua Teens must either escape the spider cocoons their landlord Marcula has trapped them in, or pay the rent they owe him, while Carl gets a new neighbor, a huge demon named Paul who is going through a difficult custody battle.
When the gangs' spring break trip to Yosemite National Park is canceled, they get to stay on PCA campus and have fun with no-one else around. However, Dean Rivers later accuses them of vandalism.
Simon wants to work at the practice again, and Snell has a proposition for Gloria.
Mr Ashlow arrives in Candleford looking for his estranged daughters, Ruby and Pearl Pratt. Can they forgive him for deserting them when they needed him most? Caroline hides from a bailiff.
Nick Harwell arrives to train Ben but becomes interested in buying Spartan. Mallory thinks Lou plans to re-home Copper and runs away with him, only to discover a plot to sell wild mustangs.
"Just because they're in the street doesn't mean they lack opinions." - Haynes While the crew awaits a showdown with Omar, Marlo celebrates a business deal. Meanwhile, at the Sun, McNulty and Freamon take advantage of a development regarding the murder of the homeless people, while Dukie heads to Cutty's gym. Also, Herc does Carver a favor as a means to make amends for his past behavior, while Davis takes his case to the court of public opinion.