Mary meets her secret admirer but faces legal issues on the road to romance. When a philandering hotel guest (guest star Dave Foley) loses his wedding ring at a local brothel, Mike agrees to help him find it by investigating the establishment. Meanwhile, Danny and Ed do some investigating of their own to respect a friend's last wish for justice.
After Logan authorizes Palmer to take charge of the crisis, Palmer sanctions Jack and Curtis to infiltrate the Chinese Embassy on a covert operation to capture a suspect. Tony and Michelle continue to bump into each other's personal lives, while Buchanan expresses anger at being kept out of the mission. Jack faces Audrey's wrath when a medical dilemma places Paul's life in jeopardy.
When a case from ten years is re-opened, Allison finds herself in a chaotic situation. Things continue to get messier when Allison finds out that the convicted man is innocent, and that someone she knows and trusts may have been involved in his framing.
Krypto and Ace take on a mutant dog-plant hybrid who is stealing all the trees in Metropolis.
Stan Smith is mad because after getting his wife a job (or "hobby") as a Real Estate agent, she makes more money than him. In the meantime, his daughter Hayley ran a program that helped the homeless, and Stan's son Steve had an idea to have a Bum Fight program. To get back and to try to gain more money than his wife, Stan takes Steve's idea and starts a Bum Fight Night where he takes bets and treats the homeless like wrestlers. But with the homeless petition, Stan has to end up fighting like a homeless man himself.
Sue learns that Troy is being blamed for armed robbery. Sue and Jack set out to prove whether he was part of the armed robbery or not. Darcy has gotten a job in Los Angeles and asks that Bobby go with her to Las Angeles. Bobby and his girlfriend both realize that they've each made the decision regarding Darcy's news. Bobby and Tara begin a relationship with each other. They soon find out that they have lost their love for their respective partners. Troy insists that he didn't do anything in the armed robbery. Sue tells Troy she believes him. Troy insists that he didn't do anything in the armed robbery. Sue tells troy she believes him. After the FBI learns of new video of the armed robbery Sue finds out Troy misled her because he is in the video.
The boys hide all of the hash by using it to pave Ray's driveway. Ray's addiction to gambling and liquor gets worse. Ricky barbecues for his family with devastating effects.
Dana is stunned when she learns a big secret about her brother, Howie, at Gay Pride 2005. Mark tries to make amends with Jenny and Shane, Kit and Bette learn that their father, Melvin, is refusing treatment for his illness, and a shocking memory about Jenny's childhood is revealed.
When five young people are found dead by the tracks, Goren and Eames initially write them off as a suicide until their investigation reveals that one of the victims, Carmine Ruggiero, had no desire to be part of a suicide pact. Although initially they begin looking into a website that gives instructions on how to committ suicide, their investigation leads them to the unsolved suicide of Edie Elverson, one of Ruggiero's co-workers, whom he had once testifed against in a harrassment suit. Goren soon realises that another of the company's employees, Hubert Skoller, is trying very hard to push them to an answer.
When a pregnant nun is found dead, Jordan, Woody, and Nigel are thrown into this case of biblical proportions. Elsewhere, Dr. Macy is on the trail of a black widow. Will be prove her innocent or become her next victim.
A convicted serial killer will be paroled after 25 years in prison unless Lilly and her team can connect him to the 1977 murder of a young doorman found strangled on a train platform. The killing is eerily similar to other murders committed by the man. Making the case more urgent is the fact that the convicted strangler hints that he will kill again upon release. Elsewhere, Scotty confronts Christina about her past and tries to get her to talk to a New York detective.
It's the end of the semester and Zoey and her friends are excited for PCA's annual beach party but... they end up going to the wrong beach unsupervised. It turns out that they aren't at Mystic Beach (where the big PCA party is) and have no way of getting back. But, they throw their own party and Quinn works her magic and finds a way to go back home.
Peggy helps weather-girl Nancy fight back when she's replaced by a qualified meteorologist. Also, a boy barking like a dog scares Bobby.
A powerful sorceress switches bodies with Phoebe, who ends up trapped in the Underworld. Meanwhile, Paige faces a big problem when her new charge refuses her help.
Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.
The Simpsons' roof springs a leak when the perfect storm hits Springfield. And when Marge asks what type of father can't keep a roof over his family's head, Homer tries to fix things up, but falls through the roof. Sick of being unwanted, Homer befriends a man who works as a roofer. However, no one else can see him and Homer's insistence that the roofer does exist prompts everyone to think he has gone crazy.
When Bart endangers his health by bingeing on vending-machine food, the Simpsons turn their home into a hostel in order to afford sending him to a forced starvation facility.
Peter and Lois decide to go on a second honeymoon. But when Peter crashes the car, he decides to pose as Mel Gibson to stay in his fancy hotel suite, where they find a copy of a "The Passion of the Christ" sequel. They attempt to destroy the film and end up being chased by two priests who went to retrieve the film.
Izzie tries to get George to find the courage to ask Meredith out. All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman's prognosis is not good. Now that Bailey knows about Meredith and Derek's affair, their jobs are in jeopardy, and she advises Meredith to end it. Meanwhile, Cristina and Burke's secret relationship is also getting more complicated...