When a college student is beaten, shot to death and his apartment ransacked in what appears to be a drug-related hit, the team must track down his killers. After examining the evidence in the murdered student's apartment, the team finds traces of pure, unprocessed heroin and discovers that the victim had a female roomate who is now missing. Meanwhile, Stella's aggressive interrogation tactics with a witness threaten her police badge.
Nadia's former caretaker, Sophia, has been severely beaten. She contacts Nadia and asks to meet her. Sloane is told by Sophia that she was beaten up, because someone is trying to track Nadia down, so he and Jack decide to tell their daughters the truth – Elena Derevko, the third and the most cruelest of the Derevko sisters, has been surveilling both Sydney and Nadia for a decade. Meanwhile, Jack's doctor advises him to tell Sydney about his illness.
In preparation for pursuing a teaching career, Eric receives his high school transcripts and discovers that he received an incomplete in gym class. He enrolls in a summer gym course and learns that his new P.E. teacher is none other than Casey Kelso! Kelso and Fez move into their new apartment and compete over who gets the master bedroom. While they do this, Red exacts his revenge for the messes they’ve created at his house over the years.
The spies investigate a strange affliction where numerous talented teens (entertainers, athletes, etc.) mysteriously have lost their abilities. The spies trace the phenomenon to a talent camp, where teens go to further hone their skills. The spies go undercover and find that an evil and bitter villain is able to somehow extract the talent from the teens and administer it to herself. The spies try to defeat the villain before they lose all of their own personal talents. In a b-story, the girls decide to throw their first big house party.
When a boy who can make people lose their memories robs the Talon, Clark goes after him but gets total amnesia. Chloe finds out what happened and has to tutor Clark in the use of his superpowers and make sure he doesn't accidentally reveal his secret. While Clark, Chloe, and Lois try to track down Kevin, Clark takes advantage of his "new life" to ask Lana on a date. And Lex tries to turn Clark's memory loss to his advantage by getting him to reveal the secret of the caves.
When a classmate's boyfriend threatens to post a humiliating video of the girl online if she dumps him, Veronica helps her concoct a scheme to ensure "mutually assured destruction" if he doesn't allow the relationship to end peacefully. Meanwhile, Keith begins to search for Duncan after his parents post a huge reward for information on his whereabouts. Later, as her secret new relationship heats up, Veronica learns a disturbing new fact about the night that she was drugged and assaulted.
Elliot is torn between moving too quickly and ruining her new relationship with Jake. Dr. Cox teaches Turk about having a healthy ego and Dr. Kelso and the Janitor fight over who gets to use the motorized cart.
Just as Monica and Vic get close to a big break in the Garage Sting, Chief Phillips unexpectedly hands over the bust to the Organized Crime Unit. He blames the decision on an emerging PR scandal involving a videotape of Vic at the church bust that was leaked to the Assistant Chief through Aceveda's office. Vic uses his leverage with the Byz Lats to find a Russian mob leader before the mobster flees the country. Monica threatens two foster care social workers with jail after a young girl is found close to death in her foster home, then tells Julien if he doesn't put in for a transfer, she'll request one for him herself.
When Rory tells her beau she can't have a casual relationship with him, he gives her an unexpected response. Sookie finds herself confined to her bed.
After a marine is murdered in the school campus the team discovers a possible suspect for his murder, but they are soon leaded back to zero point when they find the suspect murdered. Tim & Abby discover a trace to a ""Red Cell"" in the e-mails and the team believes that maybe the marine was involved in a serious game...
A woman who comes to the office to sell purses gets the male members of staff excited. She rejects Dwight's advances, but Michael reckons he's still in with a chance.
Michael tries to leave for a golfing trip with a friend, but the family keeps distracting him.
On his way home from seeing Haley, Nathan stops to visit Taylor hoping for some fun and maybe more. Meanwhile, Anna gets a surprise visit from her ex-girlfriend and is inspired to tell her parents about her sexuality. Also, Lucas works with Andy to bring Dan down, Karen puts her foot down with Brooke. Peyton and Jake continue to hide baby Jenny from Nicki.
When Stacie claps eyes on her estranged husband Jake who left her five years ago taking everything she owned with him, she's certain he is to be the gang's next mark. Having graduated from the short con world to the professional poker circuit, he's good and he won't be an easy target. But the team swears to exact revenge on him for Stacie. Is Stacie really prepared to leave her friends for love? Or has she really got another card up her sleeve....?
Krypto gets amnesia due to red kryptonite and can't remember who he is. The Junkyard Dogs try to turn him into a bad dog.
Streaky accidently gets the power of invisibility. However, he soon learns the about the problems it causes.
Chloe is unexpectedly thrust into fieldwork when a woman reports that her boyfriend may be part of the terrorist conspiracy. Jack and Curtis find their latest efforts to trap Marwan thwarted by the Secret Service, who have orders to arrest Jack for insubordination. Mike calls on ex-President David Palmer for help as Logan continues to display a lack of leadership.
Evidence shows that a pilot is indeed guilty of his wife's murder. However, in Allison’s dream, when the pilot is put in jail, there is a plane crash where hundreds of people are killed. Should Allison put forth the evidence to land this guilty man in jail, or let him go free in order to save hundreds of innocent lives?