While eating at a new cafe with Deacon, Doug manages to agitate their waitress so much that she demands they fight once her shift ends. Meanwhile, Carrie asks Holly to go shopping with her, only so that she can use her van.
A group of superdogs from outerspace come to earth to catch a villainous cat who has been wreaking havoc all over the cosmos.
When secret government installations are being invaded by mysterious unseen forces, the spies are sent to investigate. It seems that bugs have been trained by someone as part of a plot to destroy the earth. The only survivors will be the insects and their half-human, half-insect king Max Exterminus (Exterminus has been injecting himself with cockroach DNA). Of course, every king needs a queen, so Max Exterminus kidnaps Alex. In a b-story, Alex starts dating a somber goth guy.
When Carla and J.D. go out to let Carla have some fun, they get drunk and end up accidentally kissing. Dr. Cox gets the hammer dropped by Jordan, when Jack has to get stitches under Perry's watch. Elliot has trouble with a male patient, who has taken enhancement pills.
The gang are on the verge of completing a job but Albert's gone AWOL. When he finally appears it's all too late because 'the mark' has pulled out - but Albert has a new plan.
Veronica investigates who at school is doing everything possible to distract Sabrina from studying and wreck her grades in an obvious attempt to sabotage her chances at becoming valedictorian. Meanwhile, an unsavory, rival private investigator makes Keith a business offer. Later, Veronica pursues a risky lead that could discredit Abel Koontz's confession, as Logan stumbles onto her detailed files on everyone connected to Lilly's murder.
When Monica puts Vic on the trail of an escaped fugitive in Farmington, he must continue to prove his worth while playing it straight. Claudette gets suspicious of the D.A's motives when she and Dutch are assigned to investigate a major drug dealer who ends up being a minor offender. David seeks an illicit outlet for the troubling feelings caused by his rape. Vic decides to bring Shane closer as his fears about Shane's connection to Antwon Mitchell rise.
Michael doesn't want to upset the staff so he gets Dwight to pass on news about the company's reduced health provisions. Fed up with his nosiness, Jim and Pam pretend they are suffering from a variety of conditions including Ebola, Mad Cow Disease, spontaneous dentohydroplosion, hotdog fingers, nano-robot infection...
CTU raids Marwan's hideout, but he manages to slip through their fingers. Luckily, Jack locates a lead that may help him identify Marwan's next target. Tony becomes suspicious of Michelle's personal life, while Audrey reunites with Paul and learns the extent of his injuries. Anderson closes in on his quarry, as President Keeler searches for words that will comfort the American public.
The light heavyweight semi-finals are up. Stephan Bonnar fights his close friend and training partner Mike Swick in the first bout. Forrest Griffin finds out if his cut has healed enough to fight Sam Hoger or give up his chance for the contract to alternate Bobby Southworth.
George Sr. tries to find a way to attend an anniversary dinner for Lucille while Michael deliberately offends Ann's devout Christian parents. Tobias goes overboard performing his "Mrs. Featherbottom" persona.
The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.
After Shelbyville accuses Springfield of being hicks, Marge convinces the townspeople to fund a Frank Gehry-designed concert hall, which is then converted to a prison when the concert hall goes bankrupt on opening night. Meanwhile, Bart and Lisa investigate Snowball II's recent weight gain.
Doc Cochran advises Dan and Johnny how to help Swearengen's recovery. Thriving business at a new brothel leads to a startling discovery by Tolliver. Merrick gets a scoop from Yankton about gold claims. Bullock's badge comes in handy for Commissioner Jarry.
The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile Meredith puts her career on the line to save a newborn in the hospital nursery, and the other interns learn that it takes more than just medical knowledge to be good at their jobs.
When Francis and Piama choose to celebrate Francis' 21st birthday at the house, Hal is reminded of a promise he made to his son as a young child, involving a motorcycle trip that Lois quickly forbids. Hal and Francis have no choice but to sneak off for their wild adventure, leaving their women behind. Meanwhile Malcolm, Dewey and Reese are held captive in their own home by a bully.
The unsolved 1963 murder of a black teenager, whose body was discovered by the then-young Will Jeffries, is reopened.
When Nicole pays for a backpack she messed up at the bookstore, she is broke and calling the backpack stupid. But when Zoey re-designed the backpack using her ideas, Nicole likes it and keeps it. Later on, Zoey's backpack idea is stolen from a girl named, Stacy and she makes a lot of money. So then Zoey and the gang try to seek revenge on her.
Randy makes an odd request of Sue. He asks her for some help with woman he is about to meet there is one problem in the correspondence Randy and his date have shared over the computer she forgot to tell Randy she was deaf. Sue now has to accompany Randy on his date to help him with the sign language.